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Items: 1 to 20 of 55

1.
Differential effects of glutamine inhibition strategies on anti-tumor CD8 T cells
Matthew Z. Madden, Xiang Ye, Channing Chi, Emilie L. Fisher, Melissa M. Wolf, Gabriel A. Needle, Jackie E. Bader, Andrew R. Patterson, Bradley I. Reinfeld, Madelyn D. Landis, Emma S. Hathaway, Jason E. Muka, Richard T. O’Neil, John Karijolich, Mary Philip, Jeffrey C. Rathmell
J Immunol. Author manuscript; available in PMC 2024 Aug 15.
Published in final edited form as: J Immunol. 2023 Aug 15; 211(4): 563–575. doi: 10.4049/jimmunol.2200715
PMCID:
PMC10526752
AbstractArticlePDF–2.9M
2.
Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis
Zheyi Xiang, Le Bai, Jennifer Q. Zhou, Ricardo R. Cevallos, Jonathan R. Sanders, Gang Liu, Karen Bernard, Yan Y. Sanders
Mol Metab. 2023 Jan; 67: 101655. Published online 2022 Dec 13. doi: 10.1016/j.molmet.2022.101655
PMCID:
PMC9827063
AbstractArticlePDF–2.0M
3.
Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren's Syndrome
Jiayao Fu, Yiping Pu, Baoli Wang, Hui Li, Xiujuan Yang, Lisong Xie, Huan Shi, Zhijun Wang, Junhao Yin, Tianle Zhan, Yanxiong Shao, Changyu Chen, Qi Luo, Jiabao Xu, Zirui Zong, Xindi Wei, Wanwen Xiao, Chuangqi Yu, Lingyan Zheng
J Immunol Res. 2022; 2022: 3210200. Published online 2022 Feb 15. doi: 10.1155/2022/3210200
PMCID:
PMC8863479
AbstractArticlePDF–3.0M
4.
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
Yunxing Li, Sekar Ramachandran, Thuy-Tien T. Nguyen, Clint A. Stalnecker, Richard A. Cerione, Jon W. Erickson
J Biol Chem. 2020 Jan 31; 295(5): 1328–1337. Published online 2019 Dec 23. doi: 10.1074/jbc.RA119.010314
PMCID:
PMC6996896
AbstractArticlePDF–2.2M
5.
Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis
Michihito Kono, Nobuya Yoshida, Kayaho Maeda, Abel Suárez-Fueyo, Vasileios C. Kyttaris, George C. Tsokos
Arthritis Rheumatol. Author manuscript; available in PMC 2020 Nov 1.
Published in final edited form as: Arthritis Rheumatol. 2019 Nov; 71(11): 1869–1878. Published online 2019 Sep 27. doi: 10.1002/art.41019
PMCID:
PMC6817384
AbstractArticle
6.
Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease
Ge Gao, Shu Zhao, Xiaohuan Xia, Chunhong Li, Congcong Li, Chenhui Ji, Shiyang Sheng, Yalin Tang, Jie Zhu, Yi Wang, Yunlong Huang, Jialin C. Zheng
Front Cell Neurosci. 2019; 13: 264. Published online 2019 Jun 28. doi: 10.3389/fncel.2019.00264
PMCID:
PMC6611423
AbstractArticlePDF–4.9M
7.
Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice
Yi Wang, Yuju Li, Runze Zhao, Beiqing Wu, Blaise Lanoha, Zenghan Tong, Justin Peer, Jianhui Liu, Huangui Xiong, Yunlong Huang, Jialin Zheng
Brain Behav Immun. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: Brain Behav Immun. 2017 Nov; 66: 135–145. Published online 2017 Jun 15. doi: 10.1016/j.bbi.2017.06.007
PMCID:
PMC5650935
AbstractArticlePDF–830K
8.
Glutamine fuels proliferation but not migration of endothelial cells
Boa Kim, Jia Li, Cholsoon Jang, Zoltan Arany
EMBO J. 2017 Aug 15; 36(16): 2321–2333. Published online 2017 Jun 29. doi: 10.15252/embj.201796436
PMCID:
PMC5556269
AbstractArticlePDF–3.0M
9.
Role of glutamine and interlinked asparagine metabolism in vessel formation
Hongling Huang, Saar Vandekeere, Joanna Kalucka, Laura Bierhansl, Annalisa Zecchin, Ulrike Brüning, Asjad Visnagri, Nadira Yuldasheva, Jermaine Goveia, Bert Cruys, Katleen Brepoels, Sabine Wyns, Stephen Rayport, Bart Ghesquière, Stefan Vinckier, Luc Schoonjans, Richard Cubbon, Mieke Dewerchin, Guy Eelen, Peter Carmeliet
EMBO J. 2017 Aug 15; 36(16): 2334–2352. Published online 2017 Jun 29. doi: 10.15252/embj.201695518
PMCID:
PMC5556263
AbstractArticlePDF–1.9M
10.
TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
Kaizhe Wang, Ling Ye, Hongfang Lu, Huili Chen, Yanyan Zhang, Yunlong Huang, Jialin C. Zheng
J Neuroinflammation. 2017; 14: 87. Published online 2017 Apr 20. doi: 10.1186/s12974-017-0853-2
PMCID:
PMC5399318
AbstractArticlePDF–1.5M
11.
Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators
Clint A. Stalnecker, Jon W. Erickson, Richard A. Cerione
J Biol Chem. 2017 Apr 14; 292(15): 6095–6107. Published online 2017 Feb 14. doi: 10.1074/jbc.M116.758219
PMCID:
PMC5391743
AbstractArticlePDF–3.3M
12.
Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis
Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino, Akio Morinobu
Arthritis Res Ther. 2017; 19: 76. Published online 2017 Apr 11. doi: 10.1186/s13075-017-1283-3
PMCID:
PMC5387190
AbstractArticlePDF–1.6M
13.
Determination of Phosphate-activated Glutaminase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)
Dennis Botman, Wikky Tigchelaar, Cornelis J.F. Van Noorden
J Histochem Cytochem. 2014 Nov; 62(11): 813–826. doi: 10.1369/0022155414551177
PMCID:
PMC4230542
AbstractArticlePDF–1.5M
14.
Network of brain protein level changes in glutaminase deficient fetal mice
Narkhyun Bae, Yvonne Wang, Lin Li, Stephen Rayport, Gert Lubec
J Proteomics. Author manuscript; available in PMC 2014 Mar 27.
Published in final edited form as: J Proteomics. 2013 Mar 27; 80: 10.1016/j.jprot.2013.01.013. Published online 2013 Jan 30. doi: 10.1016/j.jprot.2013.01.013
PMCID:
PMC3874211
AbstractArticlePDF–1.2M
15.
Synaptic Underpinnings of Altered Hippocampal Function in Glutaminase Deficient Mice During Maturation
Inna Gaisler-Salomon, Yvonne Wang, Nao Chuhma, Hong Zhang, Yaela N. Golumbic, Andra Mihali, Ottavio Arancio, Etienne Sibille, Stephen Rayport
Hippocampus. Author manuscript; available in PMC 2013 May 1.
Published in final edited form as: Hippocampus. 2012 May; 22(5): 1027–1039. Published online 2012 Mar 19. doi: 10.1002/hipo.22014
PMCID:
PMC3531559
AbstractArticlePDF–885K
16.
Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia
Inna Gaisler-Salomon, Gretchen M Miller, Nao Chuhma, Sooyeon Lee, Hong Zhang, Farhad Ghoddoussi, Nicole Lewandowski, Stephen Fairhurst, Yvonne Wang, Agnès Conjard-Duplany, Justine Masson, Peter Balsam, René Hen, Ottavio Arancio, Matthew P Galloway, Holly M Moore, Scott A Small, Stephen Rayport
Neuropsychopharmacology. Author manuscript; available in PMC 2010 Mar 1.
Published in final edited form as: Neuropsychopharmacology. 2009 Sep; 34(10): 2305–2322. Published online 2009 Jun 10. doi: 10.1038/npp.2009.58
PMCID:
PMC2811085
AbstractArticlePDF–2.1M
17.
NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function
Ajay Kumar, Emily L. Yarosz, Anthony Andren, Li Zhang, Costas A. Lyssiotis, Cheong-Hee Chang
Cell Rep. Author manuscript; available in PMC 2022 Nov 15.
Published in final edited form as: Cell Rep. 2022 Oct 25; 41(4): 111516. doi: 10.1016/j.celrep.2022.111516
PMCID:
PMC9664378
AbstractArticlePDF–2.5M
18.
Targeting hepatic Glutaminase 1 ameliorates Non-Alcoholic Steatohepatitis by restoring Very-Low Density Lipoproteins triglyceride assembly
Jorge Simon, Maitane Nuñez-García, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández-Ramos, Beatriz Gómez-Santos, Xabier Buqué, Fernando Lopitz-Otsoa, Naroa Goikoetxea-Usandizaga, Marina Serrano-Macia, Rubén Rodriguez-Agudo, Maider Bizkarguenaga, Imanol Zubiete-Franco, Virginia Gutiérrez-de Juan, Diana Cabrera, Cristina Alonso, Paula Iruzubieta, Manuel Romero-Gomez, Sebastiaan van Liempd, Azucena Castro, Ruben Nogueiras, Marta Varela-Rey, Juan Manuel Falcón-Pérez, Erica Villa, Javier Crespo, Shelly C. Lu, Jose M. Mato, Patricia Aspichueta, Teresa Cardoso Delgado, María Luz Martínez-Chantar
Cell Metab. Author manuscript; available in PMC 2021 Mar 3.
Published in final edited form as: Cell Metab. 2020 Mar 3; 31(3): 605–622.e10. Published online 2020 Feb 21. doi: 10.1016/j.cmet.2020.01.013
PMCID:
PMC7259377
AbstractArticlePDF–1.4M
19.
Spontaneous colitis in IL‐10‐deficient mice was ameliorated via inhibiting glutaminase1
Jing Li, Lugen Zuo, Yun Tian, Yifan He, Zhichao Zhang, Pu Guo, Yuanyuan Ge, Jianguo Hu
J Cell Mol Med. 2019 Aug; 23(8): 5632–5641. Published online 2019 Jun 18. doi: 10.1111/jcmm.14471
PMCID:
PMC6653008
AbstractArticlePDF–1.8M
20.
Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS
Yunxing Li, Jon W. Erickson, Clint A. Stalnecker, William P. Katt, Qingqiu Huang, Richard A. Cerione, Sekar Ramachandran
J Biol Chem. 2016 Sep 30; 291(40): 20900–20910. Published online 2016 Aug 19. doi: 10.1074/jbc.M116.720268
PMCID:
PMC5076503
AbstractArticlePDF–2.9M

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