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Select item 106887671.

Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor-associated macrophages

Xuehan Gao, Runying Long, Ming Qin, Wenfang Zhu, Linna Wei, Pinzhi Dong, Jin Chen, Junmin Luo, Jihong Feng

Int J Mol Med. 2024 Jan; 53(1): 3. Published online 2023 Nov 8. doi: 10.3892/ijmm.2023.5327

PMCID:: PMC10688767

Abstract Article PDF–5.9M

Select item 79105862.

Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice

Xinhui Wang, Yinan Zhao, Dekun Zhou, Yingpu Tian, Gensheng Feng, Zhongxian Lu

Cell Death Dis. 2021 Feb; 12(2): 212. Published online 2021 Feb 26. doi: 10.1038/s41419-021-03519-9

PMCID:: PMC7910586

Abstract Article PDF–7.5M

Select item 48254143.

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

Shengqing Gu, Wayne W. Chan, Golam Mohi, Joel Rosenbaum, Azin Sayad, Zhibin Lu, Carl Virtanen, Shaoguang Li, Benjamin G. Neel, Richard A. Van Etten

Blood. 2016 Apr 7; 127(14): 1803–1813. Prepublished online 2016 Jan 15. doi: 10.1182/blood-2015-06-653006

PMCID:: PMC4825414

Abstract Article

Select item 29210234.

Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin

Geqiang Li, Kristy L. Miskimen, Zhengqi Wang, Xiu Yan Xie, William Tse, Fabrice Gouilleux, Richard Moriggl, Kevin D. Bunting

Leukemia. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Leukemia. 2010 Aug; 24(8): 1397–1405. Published online 2010 Jun 10. doi: 10.1038/leu.2010.131

PMCID:: PMC2921023

Abstract Article PDF–1.6M

Select item 21714085.

A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid–induced neuronal differentiation

Yingwei Mao, Angel W.-M. Lee

J Cell Biol. 2005 Jul 18; 170(2): 305–316. doi: 10.1083/jcb.200505061

PMCID:: PMC2171408

Abstract Article PDF–3.3M

Select item 18961066.

Abnormal hematopoiesis in Gab2 mutant mice

Yi Zhang, Ernesto Diaz-Flores, Geqiang Li, Zhengqi Wang, Zizhen Kang, Eleonora Haviernikova, Sara Rowe, Cheng-Kui Qu, William Tse, Kevin M. Shannon, Kevin D. Bunting

Blood. 2007 Jul 1; 110(1): 116–124. Prepublished online 2007 Mar 20. doi: 10.1182/blood-2006-11-060707

PMCID:: PMC1896106

Abstract Article

Select item 1507367.

Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells

Sho Yamasaki, Keigo Nishida, Machie Sakuma, Donna Berry, C. Jane McGlade, Toshio Hirano, Takashi Saito

Mol Cell Biol. 2003 Apr; 23(7): 2515–2529. doi: 10.1128/MCB.23.7.2515-2529.2003

PMCID:: PMC150736

Abstract Article PDF–733K

Select item 95233768.

The Gab2–MALT1 axis regulates thromboinflammation and deep vein thrombosis

Vijay Kondreddy, Shiva Keshava, Kaushik Das, Jhansi Magisetty, L. Vijaya Mohan Rao, Usha R. Pendurthi

Blood. 2022 Sep 29; 140(13): 1549–1564. doi: 10.1182/blood.2022016424

PMCID:: PMC9523376

Abstract Article

Select item 81476999.

Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction

Vijay Kondreddy, Jhansi Magisetty, Shiva Keshava, L. Vijaya Mohan Rao, Usha R. Pendurthi

Arterioscler Thromb Vasc Biol. 2021 Jun; 41(6): 1987–2005. Published online 2021 Apr 8. doi: 10.1161/ATVBAHA.121.316153

PMCID:: PMC8147699

Abstract Article PDF–4.9M

Select item 643166610.

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8⁺ T-Cell Activation

Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting

Front Immunol. 2019; 10: 486. Published online 2019 Mar 18. doi: 10.3389/fimmu.2019.00486

PMCID:: PMC6431666

Abstract Article PDF–3.7M

Select item 639570611.

Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress

Magdalena C. E. Jochner, Junfeng An, Gisela Lättig-Tünnemann, Marieluise Kirchner, Alina Dagane, Gunnar Dittmar, Ulrich Dirnagl, Britta J. Eickholt, Christoph Harms

Sci Rep. 2019; 9: 3183. Published online 2019 Feb 28. doi: 10.1038/s41598-019-39438-1

PMCID:: PMC6395706

Abstract Article PDF–3.5M

Select item 320926012.

Gab2 Promotes Colony-Stimulating Factor 1-Regulated Macrophage Expansion via Alternate Effectors at Different Stages of Development

Angel W. Lee, Yingwei Mao, Josef M. Penninger, Soojie Yu

Mol Cell Biol. 2011 Nov; 31(22): 4563–4581. doi: 10.1128/MCB.05706-11

PMCID:: PMC3209260

Abstract Article PDF–8.0M

Select item 308673713.

Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation

S Hegde, S Ni, S He, D Yoon, GS Feng, SS Watowich, RF Paulson, PA Hankey

Oncogene. Author manuscript; available in PMC 2011 May 3.

Published in final edited form as: Oncogene. 2009 Sep 24; 28(38): 3349–3359. Published online 2009 Jul 6. doi: 10.1038/onc.2009.202

PMCID:: PMC3086737

Abstract Article PDF–1.8M

Select item 298148014.

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, Cheng-Kui Qu

Blood. 2010 Nov 4; 116(18): 3611–3621. Prepublished online 2010 Jul 22. doi: 10.1182/blood-2010-01-265652

PMCID:: PMC2981480

Abstract Article

Select item 217298615.

Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis

Haihua Gu, Roberto J. Botelho, Min Yu, Sergio Grinstein, Benjamin G. Neel

J Cell Biol. 2003 Jun 23; 161(6): 1151–1161. doi: 10.1083/jcb.200212158

PMCID:: PMC2172986

Abstract Article PDF–519K

Select item 897981916.

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

Corinna Spohr, Teresa Poggio, Geoffroy Andrieux, Katharina Schönberger, Nina Cabezas-Wallscheid, Melanie Boerries, Sebastian Halbach, Anna L. Illert, Tilman Brummer

Leukemia. 2022; 36(4): 970–982. Published online 2021 Dec 13. doi: 10.1038/s41375-021-01490-0