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Items: 1 to 20 of 32

1.
Genetic Localization of Interacting Modifiers Affecting Severity in a Murine Model of Polycystic Kidney Disease
Shiei Kuida, David R. Beier
Genome Res. 2000 Jan; 10(1): 49–54.
PMCID:
PMC310498
AbstractArticlePDF–372K
2.
Role of TGF-β in a Mouse Model of High Turnover Renal Osteodystrophy
Shiguang Liu, Wenping Song, Joseph H Boulanger, Wen Tang, Yves Sabbagh, Brian Kelley, Russell Gotschall, Susan Ryan, Lucy Phillips, Katie Malley, Xiaohong Cao, Tai-He Xia, Gehua Zhen, Xu Cao, Hong Ling, Paul C Dechow, Teresita M Bellido, Steven R Ledbetter, Susan C Schiavi
J Bone Miner Res. Author manuscript; available in PMC 2014 Jul 1.
Published in final edited form as: J Bone Miner Res. 2014 May; 29(5): 1141–1157. doi: 10.1002/jbmr.2120
PMCID:
PMC4076799
AbstractArticlePDF–1.6M
3.
NEK8 Links the ATR-regulated Replication Stress Response and S-phase CDK Activity to Renal Ciliopathies
Hyo Jei Claudia Choi, Jia-Ren Lin, Jean-Baptiste Vannier, Gisela G. Slaats, Andrew C. Kile, Renee D. Paulsen, Danielle K. Manning, David R. Beier, Rachel H. Giles, Simon J. Boulton, Karlene A. Cimprich
Mol Cell. Author manuscript; available in PMC 2014 Aug 22.
Published in final edited form as: Mol Cell. 2013 Aug 22; 51(4): 423–439. doi: 10.1016/j.molcel.2013.08.006
PMCID:
PMC3790667
AbstractArticlePDF–3.4M
4.
A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8
John K McCooke, Rudi Appels, Roberto A Barrero, Alice Ding, Justyna E Ozimek-Kulik, Mathew I Bellgard, Grant Morahan, Jacqueline K Phillips
BMC Genomics. 2012; 13: 393. Published online 2012 Aug 16. doi: 10.1186/1471-2164-13-393
PMCID:
PMC3441220
AbstractArticlePDF–1.7M
5.
Nek8 Regulates the Expression and Localization of Polycystin-1 and Polycystin-2
Eisei Sohara, Ying Luo, Jingjing Zhang, Danielle K. Manning, David R. Beier, Jing Zhou
J Am Soc Nephrol. 2008 Mar; 19(3): 469–476. doi: 10.1681/ASN.2006090985
PMCID:
PMC2391053
AbstractArticle
6.
A NIMA-related Kinase, Fa2p, Localizes to a Novel Site in the Proximal Cilia of Chlamydomonas and Mouse Kidney Cells
Moe R. Mahjoub, M. Qasim Rasi, Lynne M. Quarmby
Mol Biol Cell. 2004 Nov; 15(11): 5172–5186. doi: 10.1091/mbc.E04-07-0571
PMCID:
PMC524795
AbstractArticlePDF–706K
7.
Caspase-1 and the inflammasome promote polycystic kidney disease progression
Katherine I. Swenson-Fields, Christopher J. Ward, Micaila E. Lopez, Shaneann Fross, Anna L. Heimes Dillon, James D. Meisenheimer, Adib J. Rabbani, Emily Wedlock, Malay K. Basu, Kyle P. Jansson, Peter S. Rowe, Jason R. Stubbs, Darren P. Wallace, Michael P. Vitek, Timothy A. Fields
Front Mol Biosci. 2022; 9: 971219. Published online 2022 Nov 29. doi: 10.3389/fmolb.2022.971219
PMCID:
PMC9745047
AbstractArticlePDF–3.3M
8.
Defects in ciliary localization of Nek8 is associated with cystogenesis
Melissa L. Trapp, Alevtina Galtseva, Danielle K. Manning, David R. Beier, Norman D. Rosenblum, Lynne M. Quarmby
Pediatr Nephrol. Author manuscript; available in PMC 2019 Dec 3.
Published in final edited form as: Pediatr Nephrol. 2008 Mar; 23(3): 377–387. Published online 2008 Jan 9. doi: 10.1007/s00467-007-0692-y
PMCID:
PMC6890203
AbstractArticlePDF–1.3M
9.
NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection
Antonio Abeyta, Maria Castella, Celine Jacquemont, Toshiyasu Taniguchi
Cell Cycle. 2017; 16(4): 335–347. Published online 2016 Nov 28. doi: 10.1080/15384101.2016.1259038
PMCID:
PMC5324754
AbstractArticlePDF–1.2M
10.
High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease
David R. Beier
Mamm Genome. Author manuscript; available in PMC 2016 Sep 28.
Published in final edited form as: Mamm Genome. 2016 Jun; 27(5-6): 191–199. Published online 2016 Apr 25. doi: 10.1007/s00335-016-9633-z
PMCID:
PMC5039125
AbstractArticlePDF–581K
11.
ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning
Peter G. Czarnecki, George C. Gabriel, Danielle K. Manning, Mikhail Sergeev, Kristi Lemke, Nikolai T. Klena, Xiaoqin Liu, Yu Chen, You Li, Jovenal T. San Agustin, Maija K. Garnaas, Richard J. Francis, Kimimasa Tobita, Wolfram Goessling, Gregory J. Pazour, Cecilia W. Lo, David R. Beier, Jagesh V. Shah
Nat Commun. Author manuscript; available in PMC 2015 Jul 20.
Published in final edited form as: Nat Commun. 2015; 6: 6023. Published online 2015 Jan 20. doi: 10.1038/ncomms7023
PMCID:
PMC4361001
AbstractArticlePDF–3.3M
12.
NEK8 Mutations Affect Ciliary and Centrosomal Localization and May Cause Nephronophthisis
Edgar A. Otto, Melissa L. Trapp, Ulla T. Schultheiss, Juliana Helou, Lynne M. Quarmby, Friedhelm Hildebrandt
J Am Soc Nephrol. 2008 Mar; 19(3): 587–592. doi: 10.1681/ASN.2007040490
PMCID:
PMC2391043
AbstractArticle
13.
Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis
Hervé Husson, Sarah Moreno, Laurie A. Smith, Mandy M. Smith, Ryan J. Russo, Rose Pitstick, Mikhail Sergeev, Steven R. Ledbetter, Nikolay O. Bukanov, Monica Lane, Kate Zhang, Katy Billot, George Carlson, Jagesh Shah, Laurent Meijer, David R. Beier, Oxana Ibraghimov-Beskrovnaya
Hum Mol Genet. 2016 Jun 1; 25(11): 2245–2255. Published online 2016 Apr 5. doi: 10.1093/hmg/ddw093
PMCID:
PMC5081056
AbstractArticlePDF–1.0M
14.
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models
Thomas A Natoli, Laurie A Smith, Kelly A Rogers, Bing Wang, Svetlana Komarnitsky, Yeva Budman, Alexei Belenky, Nikolay O Bukanov, William R Dackowski, Hervé Husson, Ryan J Russo, James A Shayman, Steven R Ledbetter, John P Leonard, Oxana Ibraghimov-Beskrovnaya
Nat Med. Author manuscript; available in PMC 2013 May 21.
Published in final edited form as: Nat Med. 2010 Jul; 16(7): 788–792. Published online 2010 Jun 20. doi: 10.1038/nm.2171
PMCID:
PMC3660226
ArticlePDF–1.7M
15.
Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
Amandine Viau, Khalil El Karoui, Denise Laouari, Martine Burtin, Clément Nguyen, Kiyoshi Mori, Evangéline Pillebout, Thorsten Berger, Tak Wah Mak, Bertrand Knebelmann, Gérard Friedlander, Jonathan Barasch, Fabiola Terzi
J Clin Invest. 2010 Nov 1; 120(11): 4065–4076. Published online 2010 Oct 1. doi: 10.1172/JCI42004
PMCID:
PMC2964970
AbstractArticlePDF–6.9M
16.
Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects
Danielle K. Manning, Mikhail Sergeev, Roy G. van Heesbeen, Michael D. Wong, Jin-Hee Oh, Yan Liu, R. Mark Henkelman, Iain Drummond, Jagesh V. Shah, David R. Beier
J Am Soc Nephrol. 2012 Dec 28; 24(1): 100–112. Published online 2012 Dec 28. doi: 10.1681/ASN.2012050490
PMCID:
PMC3537214
AbstractArticle
17.
Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation
Valentina Grampa, Marion Delous, Mohamad Zaidan, Gweltas Odye, Sophie Thomas, Nadia Elkhartoufi, Emilie Filhol, Olivier Niel, Flora Silbermann, Corinne Lebreton, Sophie Collardeau-Frachon, Isabelle Rouvet, Jean-Luc Alessandri, Louise Devisme, Anne Dieux-Coeslier, Marie-Pierre Cordier, Yline Capri, Suonavy Khung-Savatovsky, Sabine Sigaudy, Rémi Salomon, Corinne Antignac, Marie-Claire Gubler, Alexandre Benmerah, Fabiola Terzi, Tania Attié-Bitach, Cécile Jeanpierre, Sophie Saunier
PLoS Genet. 2016 Mar; 12(3): e1005894. Published online 2016 Mar 11. doi: 10.1371/journal.pgen.1005894
PMCID:
PMC4788435
AbstractArticlePDF–5.8M
18.
Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models
Pamela V. Tran, George C. Talbott, Annick Turbe-Doan, Damon T. Jacobs, Michael P. Schonfeld, Luciane M. Silva, Anindita Chatterjee, Mary Prysak, Bailey A. Allard, David R. Beier
J Am Soc Nephrol. 2014 Oct; 25(10): 2201–2212. Published online 2014 Apr 3. doi: 10.1681/ASN.2013070735
PMCID:
PMC4178433
AbstractArticle
19.
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
Sylvia Hoff, Jan Halbritter, Daniel Epting, Valeska Frank, Thanh-Minh T. Nguyen, Jeroen van Reeuwijk, Christopher Boehlke, Christoph Schell, Takayuki Yasunaga, Martin Helmstädter, Miriam Mergen, Emilie Filhol, Karsten Boldt, Nicola Horn, Marius Ueffing, Edgar A. Otto, Tobias Eisenberger, Mariet W. Elting, Joanna A.E. van Wijk, Detlef Bockenhauer, Neil J. Sebire, Søren Rittig, Mogens Vyberg, Troels Ring, Martin Pohl, Lars Pape, Thomas J. Neuhaus, Neveen A. Soliman Elshakhs, Sarah J. Koon, Peter C. Harris, Florian Grahammer, Tobias B. Huber, E. Wolfgang Kuehn, Albrecht Kramer-Zucker, Hanno J. Bolz, Ronald Roepman, Sophie Saunier, Gerd Walz, Friedhelm Hildebrandt, Carsten Bergmann, Soeren S. Lienkamp
Nat Genet. Author manuscript; available in PMC 2014 Feb 1.
Published in final edited form as: Nat Genet. 2013 Aug; 45(8): 951–956. Published online 2013 Jun 23. doi: 10.1038/ng.2681
PMCID:
PMC3786259
AbstractArticlePDF–1.1M
20.
The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch
Nathan E. Hellman, Yan Liu, Erin Merkel, Christina Austin, Stephanie Le Corre, David R. Beier, Zhaoxia Sun, Neeraj Sharma, Bradley K. Yoder, Iain A. Drummond
Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43): 18499–18504. Published online 2010 Oct 11. doi: 10.1073/pnas.1005998107
PMCID:
PMC2972951
AbstractArticlePDF–558K

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