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Select item 105974191.

PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice

Samuel K. Lee, Rida A. Malik, Ji Zhou, Wei Wang, Peter L. Gross, Jeffrey I. Weitz, Rithwik Ramachandran, Bernardo L. Trigatti

Arterioscler Thromb Vasc Biol. 2023 Nov; 43(11): 2165–2178. Published online 2023 Sep 7. doi: 10.1161/ATVBAHA.123.319767

PMCID:: PMC10597419

Abstract Article PDF–2.2M

Select item 93412772.

Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction

Mikhail A. Kolpakov, Xinji Guo, Khadija Rafiq, Liudmila Vlasenko, Bahman Hooshdaran, Rachid Seqqat, Tao Wang, Xiaoxuan Fan, Douglas G. Tilley, John C. Kostyak, Satya P. Kunapuli, Steven R. Houser, Abdelkarim Sabri

Circulation. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Circulation. 2020 Aug 25; 142(8): 758–775. Published online 2020 Jun 3. doi: 10.1161/CIRCULATIONAHA.119.044340

PMCID:: PMC9341277

Abstract Article PDF–4.9M

Select item 67391613.

Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection

Kohei Tatsumi, Clare M. Schmedes, E. Reaves Houston, Emily Butler, Nigel Mackman, Silvio Antoniak

Cell Immunol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Cell Immunol. 2019 Oct; 344: 103949. Published online 2019 Jul 3. doi: 10.1016/j.cellimm.2019.103949

PMCID:: PMC6739161

Abstract Article PDF–2.0M

Select item 53321604.

Protease-Activated Receptor 4 Deficiency Offers Cardioprotection after Acute Ischemia Reperfusion Injury

Mikhail A. Kolpakov, Khadija Rafiq, Xinji Guo, Bahman Hooshdaran, Tao Wang, Liudmila Vlasenko, Yulia V. Bashkirova, Xiaoxiao Zhang, Xiongwen Chen, Sahar Iftikhar, Joseph R. Libonati, Satya P. Kunapuli, Abdelkarim Sabri

J Mol Cell Cardiol. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: J Mol Cell Cardiol. 2016 Jan; 90: 21–29. Published online 2015 Nov 28. doi: 10.1016/j.yjmcc.2015.11.030

PMCID:: PMC5332160

Abstract Article PDF–1.6M

Select item 46000195.

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice

Kazuhisa Miyakawa, Nikita Joshi, Bradley P. Sullivan, Ryan Albee, Christina Brandenberger, Hartmut Jaeschke, Mitchell R. McGill, Michael A. Scott, Patricia E. Ganey, James P. Luyendyk, Robert A. Roth

Blood. 2015 Oct 8; 126(15): 1835–1843. Prepublished online 2015 Jul 15. doi: 10.1182/blood-2014-09-598656

PMCID:: PMC4600019

Abstract Article

Select item 44378506.

Development and Characterization of Monoclonal Antibodies Against Protease Activated Receptor 4 (PAR4)

Michele M. Mumaw, Maria de la Fuente, Amal Arachiche, James K. Wahl, III, Marvin T. Nieman

Thromb Res. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Thromb Res. 2015 Jun; 135(6): 1165–1171. Published online 2015 Apr 9. doi: 10.1016/j.thromres.2015.03.027

PMCID:: PMC4437850

Abstract Article PDF–2.1M

Select item 41270927.

Targeting the anionic region of human protease activated receptor 4 (PAR4) inhibits platelet aggregation and thrombosis without interfering with hemostasis

M. M. Mumaw, M. de la Fuente, D. N. Noble, M.T. Nieman

J Thromb Haemost. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: J Thromb Haemost. 2014 Aug; 12(8): 1331–1341. Published online 2014 Jun 27. doi: 10.1111/jth.12619

PMCID:: PMC4127092

Abstract Article PDF–1.1M

Select item 40771958.

Trypsin causes platelet activation independently of known protease-activated receptors

Yingying Mao, Satya P. Kunapuli

Thromb Haemost. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Thromb Haemost. 2013 Dec; 110(6): 1241–1249. Published online 2013 Sep 12. doi: 10.1160/TH13-03-0189

PMCID:: PMC4077195

Abstract Article PDF–527K

Select item 29491909.

Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice

Yingying Mao, Ming Zhang, Ronald F Tuma, Satya P Kunapuli

J Cereb Blood Flow Metab. 2010 May; 30(5): 1044–1052. Published online 2010 Jan 20. doi: 10.1038/jcbfm.2009.283

Correction in:: J Cereb Blood Flow Metab. 2010 Jun; 30(6): 1261.

PMCID:: PMC2949190

Abstract Article PDF–563K

Select item 224844110.

A critical role for extracellular protein disulfide isomerase during thrombus formation in mice

Jaehyung Cho, Barbara C. Furie, Shaun R. Coughlin, Bruce Furie

J Clin Invest. 2008 Mar 3; 118(3): 1123–1131. Published online 2008 Feb 21. doi: 10.1172/JCI34134

PMCID:: PMC2248441

Abstract Article PDF–1.3M

Select item 1084471211.

MicroRNA‐26a alleviates tubulointerstitial fibrosis in diabetic kidney disease by targeting PAR4

Gaoting Qu, Xingyue Li, Ran Jin, Dian Guan, Jialing Ji, Shanwen Li, Huimin Shi, Pingfan Tong, Weihua Gan, Aiqing Zhang

J Cell Mol Med. 2024 Feb; 28(3): e18099. Published online 2024 Jan 2. doi: 10.1111/jcmm.18099

PMCID:: PMC10844712

Abstract Article PDF–13M

Select item 1050380112.

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nieman, Steven E. McKenzie, Christian Con Yost, Leslie A. Lange, Mary Cushman, Marguerite R. Irvin, Paul F. Bray, Robert A. Campbell

J Clin Invest. 2023 Sep 15; 133(18): e169608. Published online 2023 Sep 15. doi: 10.1172/JCI169608

PMCID:: PMC10503801

Abstract Article PDF–8.2M

Select item 890805313.

Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling

Devin Cao, Michael G. Strainic, Daniel Counihan, Shiva Sridar, Fengqi An, Wasim Hussain, Alvin H. Schmaier, Marvin Nieman, M. Edward Medof

Am J Pathol. 2022 Feb; 192(2): 361–378. doi: 10.1016/j.ajpath.2021.09.011

PMCID:: PMC8908053

Abstract Article PDF–2.5M

Select item 738437814.

Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart

Anke C. Fender, Sonja Kleeschulte, Svenja Stolte, Katja Leineweber, Markus Kamler, Johannes Bode, Na Li, Dobromir Dobrev

Basic Res Cardiol. Author manuscript; available in PMC 2021 Jan 7.

Published in final edited form as: Basic Res Cardiol. 2020 Jan 7; 115(2): 10. Published online 2020 Jan 7. doi: 10.1007/s00395-019-0771-9

PMCID:: PMC7384378

Abstract Article PDF–4.3M

Select item 611222415.

TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes

Chen Liu, Wu QiNan, Lei XiaoTian, Yang MengLiu, Gan XiaGuang, Leng WeiLing, Liang ZiWen, Zhang Ling, Yang GangYi, Chen Bing

J Diabetes Res. 2018; 2018: 7653904. Published online 2018 Aug 14. doi: 10.1155/2018/7653904

Correction in:: J Diabetes Res. 2020; 2020: 1912058.

PMCID:: PMC6112224

Abstract Article PDF–6.2M

Select item 500009016.

Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins

Thomas H. Smith, Luisa J. Coronel, Julia G. Li, Michael R. Dores, Marvin T. Nieman, JoAnn Trejo

J Biol Chem. 2016 Aug 26; 291(35): 18453–18464. Published online 2016 Jul 11. doi: 10.1074/jbc.M116.729285

PMCID:: PMC5000090

Abstract Article PDF–2.8M

Select item 480686617.

Protease-Activated Receptor 4 Induces Bladder Pain through High Mobility Group Box-1

Dimitrios E. Kouzoukas, Fei Ma, Katherine L. Meyer-Siegler, Karin N. Westlund, David E. Hunt, Pedro L. Vera

PLoS One. 2016; 11(3): e0152055. Published online 2016 Mar 24. doi: 10.1371/journal.pone.0152055

PMCID:: PMC4806866

Abstract Article PDF–559K

Select item 448779518.

Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice

N. Joshi, A. K. Kopec, K. M. O’Brien, K. L. Towery, H. Cline-Fedewa, K.J. Williams, B. L. Copple, M. J. Flick, J. P. Luyendyk

J Thromb Haemost. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: J Thromb Haemost. 2015 Jan; 13(1): 57–71. Published online 2014 Dec 11. doi: 10.1111/jth.12770

PMCID:: PMC4487795

Abstract Article PDF–2.8M

Select item 303038219.

Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets

Dongjun Li, Lauren D'Angelo, Massiel Chavez, Donna S. Woulfe

J Biol Chem. 2011 Feb 4; 286(5): 3805–3814. Published online 2010 Nov 24. doi: 10.1074/jbc.M110.118018

PMCID:: PMC3030382

Abstract Article PDF–1.7M

Select item 278200320.

Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

Prafull S. Gandhi, Michael J. Page, Zhiwei Chen, Leslie Bush-Pelc, Enrico Di Cera

J Biol Chem. 2009 Sep 4; 284(36): 24098–24105. Published online 2009 Jul 8. doi: 10.1074/jbc.M109.025403

PMCID:: PMC2782003

Abstract Article PDF–1.1M

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