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Select item 95358071.

eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior

Xuanyue Ma, Liuren Li, Ziming Li, Zhengyi Huang, Yaorong Yang, Peng Liu, Daji Guo, Yueyao Li, Tianying Wu, Ruixiang Luo, Junyu Xu, Wen‐Cai Ye, Bin Jiang, Lei Shi

EMBO Rep. 2022 Oct; 23(10): e54543. Published online 2022 Aug 22. doi: 10.15252/embr.202154543

PMCID:: PMC9535807

Abstract Article PDF–3.8M

Select item 84422772.

The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain

Sang Ho Yoon, Woo Seok Song, Sung Pyo Oh, Young Sook Kim, Myoung-Hwan Kim

Mol Brain. 2021; 14: 142. Published online 2021 Sep 15. doi: 10.1186/s13041-021-00852-0

PMCID:: PMC8442277

Abstract Article PDF–2.1M

Select item 75119533.

Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes

Maxim V. Gerashchenko, Mikhail V. Nesterchuk, Elena M. Smekalova, Joao A. Paulo, Piotr S. Kowalski, Kseniya A. Akulich, Roman Bogorad, Sergey E. Dmitriev, Steven Gygi, Timofei Zatsepin, Daniel G. Anderson, Vadim N. Gladyshev, Victor E. Koteliansky

Sci Rep. 2020; 10: 15473. Published online 2020 Sep 23. doi: 10.1038/s41598-020-72399-4

PMCID:: PMC7511953

Abstract Article PDF–7.4M

Select item 32228164.

Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase

Gyung Ah Jung, Bong Shik Shin, Yeon Sue Jang, Jae Bum Sohn, Seon Rang Woo, Jung Eun Kim, Go Choi, Kyung-Mi Lee, Bon Hong Min, Kee-Ho Lee, Gil Hong Park

Exp Mol Med. 2011 Oct 31; 43(10): 550–560. Published online 2011 Jul 21. doi: 10.3858/emm.2011.43.10.061

PMCID:: PMC3222816

Abstract Article PDF–593K

Select item 104644115.

Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells

Ke Hu, Chen Wang, Yifan Xu, Fan Li, Xuefeng Han, Chuanwang Song, Meng Liang

J Ovarian Res. 2023; 16: 171. Published online 2023 Aug 23. doi: 10.1186/s13048-023-01232-z

Correction in:: J Ovarian Res. 2023; 16: 199.

PMCID:: PMC10464411

Abstract Article PDF–3.2M

Select item 79482576.

Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.

Saahj Gosrani, Hannah Jester, Xueyan Zhou, Alexey Ryazanov, Tao Ma

Neurobiol Aging. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Neurobiol Aging. 2020 Nov; 95: 154–160. Published online 2020 Jul 25. doi: 10.1016/j.neurobiolaging.2020.07.016

PMCID:: PMC7948257

Abstract Article PDF–620K

Select item 78521377.

Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression

Weifen Li, Tahir Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, Fawad Ali Shah, Qingguo Ren, Shafiq Ur Rahman, Ningning Li, Zhi-Jian Yu, Shupeng Li

J Neuroinflammation. 2021; 18: 38. Published online 2021 Feb 1. doi: 10.1186/s12974-021-02091-5

Correction in:: J Neuroinflammation. 2022; 19: 317.

PMCID:: PMC7852137

Abstract Article PDF–3.5M

Select item 38055978.

Thiopental Inhibits Global Protein Synthesis by Repression of Eukaryotic Elongation Factor 2 and Protects from Hypoxic Neuronal Cell Death

Christian I. Schwer, Cornelius Lehane, Timo Guelzow, Simone Zenker, Karl M. Strosing, Sashko Spassov, Anika Erxleben, Bernd Heimrich, Hartmut Buerkle, Matjaz Humar

PLoS One. 2013; 8(10): e77258. Published online 2013 Oct 22. doi: 10.1371/journal.pone.0077258

PMCID:: PMC3805597

Abstract Article PDF–2.0M

Select item 27576749.

Post-Training Dephosphorylation of eEF-2 Promotes Protein Synthesis for Memory Consolidation

Heh-In Im, Akira Nakajima, Bo Gong, Xiaoli Xiong, Takayoshi Mamiya, Elliot S. Gershon, Min Zhuo, Ya-Ping Tang

PLoS One. 2009; 4(10): e7424. Published online 2009 Oct 13. doi: 10.1371/journal.pone.0007424

PMCID:: PMC2757674

Abstract Article PDF–889K

Select item 275653810.

A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses

Bénédicte F. Py, Michael Boyce, Junying Yuan

Autophagy. Author manuscript; available in PMC 2009 Oct 4.

Published in final edited form as: Autophagy. 2009 Apr; 5(3): 393–396. Published online 2009 Apr 6. doi: 10.4161/auto.5.3.7762

PMCID:: PMC2756538

Abstract Article PDF–477K

Select item 342712911.

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

Shihui Liu, Christopher Bachran, Pradeep Gupta, Sharmina Miller-Randolph, Hailun Wang, Devorah Crown, Yi Zhang, Alexander N. Wein, Rajat Singh, Rasem Fattah, Stephen H. Leppla

Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34): 13817–13822. Published online 2012 Aug 6. doi: 10.1073/pnas.1206933109

PMCID:: PMC3427129

Abstract Article PDF–751K

Select item 259259712.

Diphthamide Modification of EEF2 Requires a J-domain Protein and is Essential for Normal Development

Tom R Webb, Sally H. Cross, Lisa McKie, Ruth Edgar, Lucie Vizor, Jackie Harrison, Jo Peters, Ian J. Jackson

J Cell Sci. Author manuscript; available in PMC 2008 Dec 2.

Published in final edited form as: J Cell Sci. 2008 Oct 1; 121(Pt 19): 3140–3145. Published online 2008 Sep 2. doi: 10.1242/jcs.035550

PMCID:: PMC2592597

Abstract Article PDF–496K

Select item 928323213.

Amyloid beta induces Fmr1‐dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2

Simon Lizarazo, Yeeun Yook, Nien‐Pei Tsai

J Cell Physiol. 2022 Jul; 237(7): 2929–2942. Published online 2022 Apr 17. doi: 10.1002/jcp.30754

PMCID:: PMC9283232

Abstract Article PDF–4.0M

Select item 494834514.

Solid tumor therapy by selectively targeting stromal endothelial cells

Shihui Liu, Jie Liu, Qian Ma, Liu Cao, Rasem J. Fattah, Zuxi Yu, Thomas H. Bugge, Toren Finkel, Stephen H. Leppla

Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28): E4079–E4087. Published online 2016 Jun 29. doi: 10.1073/pnas.1600982113

PMCID:: PMC4948345

Abstract Article PDF–1.1M

Select item 278532215.

Brain-derived Neurotrophic Factor Enhances the Basal Rate of Protein Synthesis by Increasing Active Eukaryotic Elongation Factor 2 Levels and Promoting Translation Elongation in Cortical Neurons

Nobuyuki Takei, Mihoko Kawamura, Yuta Ishizuka, Naomasa Kakiya, Naoko Inamura, Hisaaki Namba, Hiroyuki Nawa

J Biol Chem. 2009 Sep 25; 284(39): 26340–26348. Published online 2009 Jul 22. doi: 10.1074/jbc.M109.023010

PMCID:: PMC2785322

Abstract Article PDF–2.4M

Select item 405527416.

IL-6 Impairs Myogenic Differentiation by Downmodulation of p90RSK/eEF2 and mTOR/p70S6K Axes, without Affecting AKT Activity

Michele Pelosi, Manuela De Rossi, Laura Barberi, Antonio Musarò

Biomed Res Int. 2014; 2014: 206026. Published online 2014 May 21. doi: 10.1155/2014/206026

PMCID:: PMC4055274

Abstract Article PDF–2.2M

Select item 257653517.

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

Liping Liu, David R. Wise, J. Alan Diehl, M. Celeste Simon

J Biol Chem. 2008 Nov 7; 283(45): 31153–31162. doi: 10.1074/jbc.M805056200

PMCID:: PMC2576535

Abstract Article PDF–901K

Select item 353329918.

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

Bárbara González-Terán, José R. Cortés, Elisa Manieri, Nuria Matesanz, ρngeles Verdugo, María E. Rodríguez, ρgueda González-Rodríguez, ρngela Valverde, Pilar Martín, Roger J. Davis, Guadalupe Sabio

J Clin Invest. 2013 Jan 2; 123(1): 164–178. Published online 2012 Dec 3. doi: 10.1172/JCI65124

Correction in:: J Clin Invest. 2014 Apr 1; 124(4): 1869.

PMCID:: PMC3533299

Abstract Article PDF–5.1M

Select item 1105316919.

Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects

Yu Shi, Daochao Huang, Cui Song, Ruixue Cao, Zhao Wang, Dan Wang, Li Zhao, Xiaolu Xu, Congyu Lu, Feng Xiong, Haowen Zhao, Shuxiang Li, Quansheng Zhou, Shuyue Luo, Dongjie Hu, Yun Zhang, Cui Wang, Yiping Shen, Weiting Su, Yili Wu, Karl Schmitz, Shuo Wei, Weihong Song

Nat Commun. 2024; 15: 3301. Published online 2024 Apr 26. doi: 10.1038/s41467-024-47670-1

PMCID:: PMC11053169

Abstract Article PDF–5.8M

Select item 424695920.

Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R

Matthew L. Kraushar, Kevin Thompson, H. R. Sagara Wijeratne, Barbara Viljetic, Kristina Sakers, Justin W. Marson, Dimitris L. Kontoyiannis, Steven Buyske, Ronald P. Hart, Mladen-Roko Rasin

Proc Natl Acad Sci U S A. 2014 Sep 9; 111(36): E3815–E3824. Published online 2014 Aug 25. doi: 10.1073/pnas.1408305111