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Select item 64335181.

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine-and cotinine-enhanced alcoholic fatty liver in mice

Xue Chen, Kesheng Wang, Arthur I. Cederbaum, Yongke Lu

Biochem Biophys Res Commun. Author manuscript; available in PMC 2020 Apr 23.

Published in final edited form as: Biochem Biophys Res Commun. 2019 Apr 23; 512(1): 119–124. Published online 2019 Mar 12. doi: 10.1016/j.bbrc.2019.03.021

PMCID:: PMC6433518

Abstract Article PDF–2.0M

Select item 61773192.

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5

Xue Chen, Emmanuel Owoseni, Julia salamat, Arthur I. Cederbaum, Yongke Lu

Arch Biochem Biophys. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Arch Biochem Biophys. 2018 Nov 1; 657: 65–73. Published online 2018 Sep 15. doi: 10.1016/j.abb.2018.09.012

PMCID:: PMC6177319

Abstract Article PDF–819K

Select item 53537973.

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver

Katia S. Poça, Thiago E. M. Parente, Lucas F. Chagas, Bruna S. Leal, Hellen S. Leal, Francisco J. R. Paumgartten, Ana C. A. X. De-Oliveira

BMC Res Notes. 2017; 10: 125. Published online 2017 Mar 15. doi: 10.1186/s13104-017-2435-x

PMCID:: PMC5353797

Abstract Article PDF–1.4M

Select item 47035594.

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference

Feng Hong, Chuanping Si, Pengfei Gao, Arthur I. Cederbaum, Huabao Xiong, Yongke Lu

Naunyn Schmiedebergs Arch Pharmacol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan; 389(1): 33–43. Published online 2015 Sep 12. doi: 10.1007/s00210-015-1172-8

PMCID:: PMC4703559

Abstract Article PDF–3.6M

Select item 44427405.

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice

Feng Hong, Xiyu Liu, Stephen Ward, Huabao Xiong, Arthur I. Cederbaum, Yongke Lu

Dig Liver Dis. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Dig Liver Dis. 2015 Jun; 47(6): 470–477. Published online 2015 Mar 6. doi: 10.1016/j.dld.2015.02.012

PMCID:: PMC4442740

Abstract Article PDF–2.8M

Select item 43119776.

Modulation of Cytochrome P450 2A5 Activity by Lipopolysaccharide: Low-Dose Effects and Non-Monotonic Dose-Response Relationship

Ana C. A. X. De-Oliveira, Kátia S. Poça, Paulo R. R. Totino, Francisco J. R. Paumgartten

PLoS One. 2015; 10(1): e0117842. Published online 2015 Jan 30. doi: 10.1371/journal.pone.0117842

PMCID:: PMC4311977

Abstract Article PDF–761K

Select item 38767917.

Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene

Jinping Hu, Li Sheng, Lei Li, Xin Zhou, Fang Xie, Jaime D’Agostino, Yan Li, Xinxin Ding

Drug Metab Dispos. 2014 Jan; 42(1): 23–27. Published online 2014 Jan. doi: 10.1124/dmd.113.054429

PMCID:: PMC3876791

Abstract Article PDF–985K

Select item 33106988.

Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice

Xin Zhou, Jaime D'Agostino, Fang Xie, Xinxin Ding

J Pharmacol Exp Ther. 2012 Apr; 341(1): 233–241. doi: 10.1124/jpet.111.190173

PMCID:: PMC3310698

Abstract Article PDF–370K

Select item 28121119.

Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model

Xin Zhou, Xiaoliang Zhuo, Fang Xie, Kerri Kluetzman, Yue-Zhong Shu, W. Griffith Humphreys, Xinxin Ding

J Pharmacol Exp Ther. 2010 Feb; 332(2): 578–587. doi: 10.1124/jpet.109.162610

PMCID:: PMC2812111

Abstract Article PDF–227K

Select item 121696510.

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

O Geneste, F Raffalli, M A Lang

Biochem J. 1996 Feb 1; 313(Pt 3): 1029–1037. doi: 10.1042/bj3131029

PMCID:: PMC1216965

Summary PDF–442K

Select item 113456111.

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

R O Juvonen, M Iwasaki, T Sueyoshi, M Negishi

Biochem J. 1993 Aug 15; 294(Pt 1): 31–34. doi: 10.1042/bj2940031

PMCID:: PMC1134561

Summary Page Browse PDF–729K

Select item 113305312.

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

B Hahnemann, P Salonpää, M Pasanen, J Mäenpää, P Honkakoski, R Juvonen, M A Lang, O Pelkonen, H Raunio

Biochem J. 1992 Aug 15; 286(Pt 1): 289–294. doi: 10.1042/bj2860289

PMCID:: PMC1133053

Summary Page Browse PDF–1.5M

Select item 808734513.

High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis

Xue Chen, George K. Acquaah-Mensah, Krista L. Denning, Jonathan M. Peterson, Kesheng Wang, James Denvir, Feng Hong, Arthur I. Cederbaum, Yongke Lu

Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1; 319(5): G626–G635. Published online 2020 Sep 2. doi: 10.1152/ajpgi.00213.2020

PMCID:: PMC8087345

Abstract Article

Select item 513026914.

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

Kazuhiro Kanemoto, Katsuhiro Fukuta, Noriyasu Kawai, Keiichi Tozawa, Masako Ochiai, Koji Okamoto, Sumiko Ohnami, Hiromi Sakamoto, Teruhiko Yoshida, Yae Kanai, Masaru Katoh, Takahiro Yasui, Kenjiro Kohri, Tadao Kakizoe, Hitoshi Nakagama

PLoS One. 2016; 11(11): e0167374. Published online 2016 Nov 30. doi: 10.1371/journal.pone.0167374