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Select item 101202091.

Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Arshi Khanam, Alip Ghosh, Joel V. Chua, Shyam Kottilil

J Transl Med. 2023; 21: 271. Published online 2023 Apr 21. doi: 10.1186/s12967-023-04104-8

PMCID:: PMC10120209

Abstract Article PDF–6.8M

Select item 82501202.

Upregulation of CCR4 in activated CD8⁺ T cells indicates enhanced lung homing in patients with severe acute SARS‐CoV‐2 infection

Silvia Spoerl, Anita N. Kremer, Michael Aigner, Nina Eisenhauer, Pauline Koch, Lina Meretuk, Patrick Löffler, Matthias Tenbusch, Clara Maier, Klaus Überla, Lucie Heinzerling, Benjamin Frey, Gloria Lutzny‐Geier, Thomas H. Winkler, Gerhard Krönke, Marcel Vetter, Heiko Bruns, Markus F. Neurath, Andreas Mackensen, Andreas E. Kremer, Simon Völkl

Eur J Immunol. 2021 Jun; 51(6): 1436–1448. Published online 2021 Apr 19. doi: 10.1002/eji.202049135

PMCID:: PMC8250120

Abstract Article PDF–1.3M

Select item 75775613.

CCR4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders and its implications for diagnosis and treatment.

Shamir Geller, Travis J. Hollmann, Steven M. Horwitz, Patricia L. Myskowski, Melissa Pulitzer

Histopathology. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Histopathology. 2020 Jan; 76(2): 222–232. Published online 2019 Nov 13. doi: 10.1111/his.13960

PMCID:: PMC7577561

Abstract Article PDF–1.2M

Select item 56200464.

Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior

Xi Cheng, Huo Wu, Zhi-Jian Jin, Ding Ma, Stanley Yuen, Xiao-Qian Jing, Min-Min Shi, Bai-Yong Shen, Cheng-Hong Peng, Ren Zhao, Wei-Hua Qiu

Sci Rep. 2017; 7: 12362. Published online 2017 Sep 28. doi: 10.1038/s41598-017-10267-4

PMCID:: PMC5620046

Abstract Article PDF–2.9M

Select item 52169675.

CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer

Baochi Ou, Jingkun Zhao, Shaopei Guan, Hao Feng, Xiongzhi Wangpu, Congcong Zhu, Yaping Zong, Junjun Ma, Jing Sun, Xiaohui Shen, Minhua Zheng, Aiguo Lu

Oncotarget. 2016 Jul 26; 7(30): 47637–47649. Published online 2016 Jun 23. doi: 10.18632/oncotarget.10256

Correction in:: Oncotarget. 2017 Jun 20; 8(25): 41779.

PMCID:: PMC5216967

Abstract Article PDF–11M

Select item 44124746.

Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4⁺ T cells

Satya P. Singh, Maristela M. de Camargo, Hongwei H. Zhang, John F. Foley, Michael N. Hedrick, Joshua M. Farber

Eur J Immunol. Author manuscript; available in PMC 2015 Apr 28.

Published in final edited form as: Eur J Immunol. 2010 Nov; 40(11): 3183–3197. Published online 2010 Oct 20. doi: 10.1002/eji.201040443

Correction in:: volume 41 on page 2793

PMCID:: PMC4412474

Abstract Article PDF–1.8M

Select item 42672337.

Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma

Masao Nakagawa, Roland Schmitz, Wenming Xiao, Carolyn K. Goldman, Weihong Xu, Yandan Yang, Xin Yu, Thomas A. Waldmann, Louis M. Staudt

J Exp Med. 2014 Dec 15; 211(13): 2497–2505. doi: 10.1084/jem.20140987

PMCID:: PMC4267233

Abstract Article PDF–2.0M

Select item 39655718.

DISTINCT CONFORMATIONS OF THE CHEMOKINE RECEPTOR CCR4 WITH IMPLICATIONS FOR ITS TARGETING IN ALLERGY

Jonathan M. Viney, David P. Andrew, Rhian M. Phillips, Andrea Meiser, Pallavi Patel, Melissa Lennartz-Walker, David J. Cousins, Nicholas P. Barton, David A. Hall, James E. Pease

J Immunol. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: J Immunol. 2014 Apr 1; 192(7): 3419–3427. Published online 2014 Feb 21. doi: 10.4049/jimmunol.1300232

PMCID:: PMC3965571

Abstract Article PDF–2.2M

Select item 38164549.

Anti-CCR4 mAb selectively depletes effector-type FoxP3⁺CD4⁺ regulatory T cells, evoking antitumor immune responses in humans

Daisuke Sugiyama, Hiroyoshi Nishikawa, Yuka Maeda, Megumi Nishioka, Atsushi Tanemura, Ichiro Katayama, Sachiko Ezoe, Yuzuru Kanakura, Eiichi Sato, Yasuo Fukumori, Julia Karbach, Elke Jäger, Shimon Sakaguchi

Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44): 17945–17950. Published online 2013 Oct 14. doi: 10.1073/pnas.1316796110

PMCID:: PMC3816454

Abstract Article PDF–924K

Select item 338053010.

CC Chemokine Receptor 4 (CCR4) in human allergen-induced late nasal responses

G. Banfield, H. Watanabe, G. Scadding, M. R. Jacobson, S. J. Till, D. A. Hall, D. S. Robinson, C. M. Lloyd, K. T. Nouri-Aria, S. R. Durham

Allergy. Author manuscript; available in PMC 2012 Jun 21.

Published in final edited form as: Allergy. 2010 Sep; 65(9): 1126–1133. Published online 2010 Feb 10. doi: 10.1111/j.1398-9995.2010.02327.x

PMCID:: PMC3380530

Abstract Article PDF–862K

Select item 1012769311.

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem, John C. Panepinto

mBio. 2023 Mar-Apr; 14(2): e00196-23. Published online 2023 Apr 5. doi: 10.1128/mbio.00196-23

PMCID:: PMC10127693

Abstract Article PDF–3.8M

Select item 885471512.

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma

Zihang Ling, Wei Li, Jiaqi Hu, Yuanyuan Li, Miao Deng, Siyuan Zhang, Xianyue Ren, Tong Wu, Juan Xia, Bin Cheng, Xiaoan Tao

Cell Death Dis. 2022 Feb; 13(2): 158. Published online 2022 Feb 17. doi: 10.1038/s41419-022-04610-5

PMCID:: PMC8854715

Abstract Article PDF–21M

Select item 791780413.

Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex

Fusako Munakata, Masataka Suzawa, Kumiko Ui-Tei

Genes (Basel) 2021 Feb; 12(2): 271. Published online 2021 Feb 13. doi: 10.3390/genes12020271

PMCID:: PMC7917804

Abstract Article PDF–1.3M

Select item 769299314.

Tumors establish resistance to immunotherapy by regulating T_reg recruitment via CCR4

Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Brian Wong, Dirk G Brockstedt, Oezcan Talay

J Immunother Cancer. 2020; 8(2): e000764. Published online 2020 Nov 26. doi: 10.1136/jitc-2020-000764

PMCID:: PMC7692993

Abstract Article PDF–1.3M

Select item 715507215.

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation

Caroline A. Anderson, Pallavi Patel, Jonathan M. Viney, Rhian M. Phillips, Roberto Solari, James E. Pease

J Leukoc Biol. 2020 Mar; 107(3): 455–466. Published online 2020 Feb 13. doi: 10.1002/JLB.2A0120-089RR

PMCID:: PMC7155072

Abstract Article PDF–1.5M

Select item 557550016.

Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets

Jeroen K. Buskermolen, Sanne Roffel, Susan Gibbs

J Cell Physiol. 2017 Nov; 232(11): 2996–3005. Published online 2017 May 23. doi: 10.1002/jcp.25946

PMCID:: PMC5575500

Abstract Article PDF–2.1M

Select item 535476717.

Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22–CCR4 axis

Aerken Maolake, Kouji Izumi, Kazuyoshi Shigehara, Ariunbold Natsagdorj, Hiroaki Iwamoto, Suguru Kadomoto, Yuta Takezawa, Kazuaki Machioka, Kazutaka Narimoto, Mikio Namiki, Wen-Jye Lin, Guzailinuer Wufuer, Atsushi Mizokami

Oncotarget. 2017 Feb 7; 8(6): 9739–9751. Published online 2016 Dec 26. doi: 10.18632/oncotarget.14185

PMCID:: PMC5354767

Abstract Article PDF–5.0M

Select item 533072718.

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

Chiara Berlato, Moddasar N. Khan, Tiziana Schioppa, Richard Thompson, Eleni Maniati, Anne Montfort, Maryam Jangani, Monica Canosa, Hagen Kulbe, Urs B. Hagemann, Alexander R. Duncan, Laura Fletcher, Robert W. Wilkinson, Thomas Powles, Sergio A. Quezada, Frances R. Balkwill

J Clin Invest. 2017 Mar 1; 127(3): 801–813. Published online 2017 Jan 30. doi: 10.1172/JCI82976

PMCID:: PMC5330727

Abstract Article PDF–1.4M

Select item 512234319.

Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma

Wei Sun, Wei-Jin Li, Fan-Qin Wei, Thian-Sze Wong, Wen-Bin Lei, Xiao-Lin Zhu, Jian Li, Wei-Ping Wen

Oncotarget. 2016 Jun 21; 7(25): 37714–37727. Published online 2016 May 10. doi: 10.18632/oncotarget.9265

PMCID:: PMC5122343

Abstract Article PDF–7.9M

Select item 344644620.

Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RA^medvery early memory cells in granulomatosis with polyangiitis (Wegener's)

Ursula Fagin, Silke Pitann, Wolfgang L Gross, Peter Lamprecht

Arthritis Res Ther. 2012; 14(2): R73. Published online 2012 Apr 10. doi: 10.1186/ar3794

PMCID:: PMC3446446

Abstract Article PDF–304K

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