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Select item 105977761.

Adipocyte dysfunction promotes lung inflammation and aberrant repair: a potential target of COPD

Si-jin Zhang, Xian-zheng Qin, Jie Zhou, Bin-feng He, Surendra Shrestha, Jing Zhang, Wei-ping Hu

Front Endocrinol (Lausanne) 2023; 14: 1204744. Published online 2023 Oct 10. doi: 10.3389/fendo.2023.1204744

PMCID:: PMC10597776

Abstract Article PDF–4.4M

Select item 83277302.

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal

Sarah Warsi, Ulrika Blank, Maria Dahl, Tan Hooi Min Grahn, Ludwig Schmiderer, Silja Andradottir, Stefan Karlsson

Haematologica. 2021 Aug 1; 106(8): 2203–2214. Published online 2020 Jul 16. doi: 10.3324/haematol.2019.236125

PMCID:: PMC8327730

Abstract Article PDF–1.7M

Select item 71908403.

BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice

Shuwen Qian, Jiabao Pan, Yan Su, Yan Tang, Yina Wang, Ying Zou, Yaxin Zhao, Hong Ma, Youyou Zhang, Yang Liu, Liang Guo, Qi-qun Tang

Commun Biol. 2020; 3: 200. Published online 2020 Apr 29. doi: 10.1038/s42003-020-0928-y

PMCID:: PMC7190840

Abstract Article PDF–3.1M

Select item 59094224.

Oxidative stress increases M₁dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

Orrette R Wauchope, Michelle M Mitchener, William N Beavers, James J Galligan, Jeannie M Camarillo, William D Sanders, Philip J Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P Fessel, Lawrence J Marnett

Nucleic Acids Res. 2018 Apr 20; 46(7): 3458–3467. Published online 2018 Feb 9. doi: 10.1093/nar/gky089

PMCID:: PMC5909422

Abstract Article PDF–570K

Select item 43941915.

BMPR2 Preserves Mitochondrial Function and DNA Integrity During Reoxygenation to Promote Endothelial Survival and Reverse Pulmonary Hypertension

Isabel Diebold, Jan K. Hennigs, Kazuya Miyagawa, Caiyun G. Li, Nils P. Nickel, Mark Kaschwich, Aiqin Cao, Lingli Wang, Sushma Reddy, Pin-I Chen, Kiichi Nakahira, Miguel A. Alejandre Alcazar, Rachel K. Hopper, Lijuan Ji, Brian J. Feldman, Marlene Rabinovitch

Cell Metab. Author manuscript; available in PMC 2016 Apr 7.

Published in final edited form as: Cell Metab. 2015 Apr 7; 21(4): 596–608. doi: 10.1016/j.cmet.2015.03.010

PMCID:: PMC4394191

Abstract Article PDF–3.1M

Select item 42779206.

BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation

Michael W. Pickup, Laura D. Hover, Eleanor R. Polikowsky, Anna Chytil, Agnieszka E. Gorska, Sergey V. Novitskiy, Harold L. Moses, Philip Owens

Mol Oncol. 2015 Jan; 9(1): 179–191. Published online 2014 Aug 23. doi: 10.1016/j.molonc.2014.08.004

PMCID:: PMC4277920

Abstract Article PDF–3.3M

Select item 39316857.

Bone Morphogenetic Protein Signaling Protects against Cerulein-Induced Pancreatic Fibrosis

Xuxia Gao, Yanna Cao, Dustin A. Staloch, Michael A. Gonzales, Judith F. Aronson, Celia Chao, Mark R. Hellmich, Tien C. Ko

PLoS One. 2014; 9(2): e89114. Published online 2014 Feb 21. doi: 10.1371/journal.pone.0089114

PMCID:: PMC3931685

Abstract Article PDF–3.9M

Select item 39310978.

Hyperoxia Synergizes with Mutant Bone Morphogenic Protein Receptor 2 to Cause Metabolic Stress, Oxidant Injury, and Pulmonary Hypertension

Joshua P. Fessel, Charles R. Flynn, Linda J. Robinson, Niki L. Penner, Santhi Gladson, Christie J. Kang, David H. Wasserman, Anna R. Hemnes, James D. West

Am J Respir Cell Mol Biol. 2013 Nov; 49(5): 778–787. doi: 10.1165/rcmb.2012-0463OC

PMCID:: PMC3931097

Abstract Article PDF–1.1M

Select item 38182549.

Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

Andrea L. Frump, Jonathan W. Lowery, Rizwan Hamid, Eric D. Austin, Mark de Caestecker

PLoS One. 2013; 8(11): e80319. Published online 2013 Nov 5. doi: 10.1371/journal.pone.0080319

PMCID:: PMC3818254

Abstract Article PDF–1.1M

Select item 375892310.

Anti-inflammatory and anti-atherogenic role of BMP Receptor II in endothelial cells

Chan Woo Kim, Hannah Song, Sandeep Kumar, Douglas Nam, Hyuk Sang Kwon, Kyung Hwa Chang, Dong Ju Son, Dong-Won Kang, Seth A. Brodie, Daiana Weiss, J. David Vega, Noah Alberts-Grill, Kathy Griendling, W. Robert Taylor, Hanjoong Jo

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6): 1350–1359. Published online 2013 Apr 4. doi: 10.1161/ATVBAHA.112.300287

PMCID:: PMC3758923

Abstract Article PDF–4.0M

Select item 331153411.

BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines

Rachel J. Davies, Alan M. Holmes, John Deighton, Lu Long, Xudong Yang, Lucy Barker, Christoph Walker, David C. Budd, Paul D. Upton, Nicholas W. Morrell

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6): L604–L615. Published online 2012 Jan 6. doi: 10.1152/ajplung.00309.2011

PMCID:: PMC3311534

Abstract Article

Select item 330289312.

Chronic Allergic Inflammation Causes Vascular Remodeling and Pulmonary Hypertension in Bmpr2 Hypomorph and Wild-Type Mice

Elizabeth M. Mushaben, Gurjit Khurana Hershey, Michael W. Pauciulo, William C. Nichols, Timothy D. Le Cras

PLoS One. 2012; 7(3): e32468. Published online 2012 Mar 9. doi: 10.1371/journal.pone.0032468

PMCID:: PMC3302893

Abstract Article PDF–1.4M

Select item 328691113.

Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators

Philip Owens, Michael W. Pickup, Sergey V. Novitskiy, Anna Chytil, Agnieszka E. Gorska, Mary E. Aakre, James West, Harold L. Moses

Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8): 2814–2819. Published online 2011 May 16. doi: 10.1073/pnas.1101139108

PMCID:: PMC3286911

Abstract Article PDF–1.4M

Select item 320828814.

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II

Victoria J. Burton, Alan M. Holmes, Loredana I. Ciuclan, Alexander Robinson, Jan S. Roger, Gabor Jarai, Andrew C. Pearce, David C. Budd

Blood. 2011 Oct 27; 118(17): 4750–4758. Prepublished online 2011 Sep 7. doi: 10.1182/blood-2011-05-347393

PMCID:: PMC3208288

Abstract Article

Select item 314142015.

Physiologic and molecular consequences of endothelial Bmpr2 mutation

Susan Majka, Moira Hagen, Thomas Blackwell, Julie Harral, Jennifer A Johnson, Robert Gendron, Helene Paradis, Daniel Crona, James E Loyd, Eva Nozik-Grayck, Kurt R Stenmark, James West

Respir Res. 2011; 12(1): 84. Published online 2011 Jun 22. doi: 10.1186/1465-9921-12-84

PMCID:: PMC3141420

Abstract Article PDF–8.2M

Select item 163685316.

Different Routes of Bone Morphogenic Protein (BMP) Receptor Endocytosis Influence BMP Signaling

Anke Hartung, Keren Bitton-Worms, Maya Mouler Rechtman, Valeska Wenzel, Jan H. Boergermann, Sylke Hassel, Yoav I. Henis, Petra Knaus

Mol Cell Biol. 2006 Oct; 26(20): 7791–7805. Published online 2006 Aug 21. doi: 10.1128/MCB.00022-06

PMCID:: PMC1636853

Abstract Article PDF–742K

Select item 147240517.

Increased Susceptibility to Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice

Yanli Song, John E. Jones, Hideyuki Beppu, John F. Keaney, Jr., Joseph Loscalzo, Ying-Yi Zhang

Circulation. Author manuscript; available in PMC 2006 May 30.

Published in final edited form as: Circulation. 2005 Jul 26; 112(4): 553–562. Published online 2005 Jul 18. doi: 10.1161/CIRCULATIONAHA.104.492488

PMCID:: PMC1472405

Abstract Article PDF–1.3M

Select item 1061368318.

Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut–lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression

Ygor Marinho, Elizabeth S. Villarreal, Sammy Y. Aboagye, David L. Williams, Jun Sun, Claudia L. M. Silva, Sarah E. Lutz, Suellen D. Oliveira

Front Immunol. 2023; 14: 1254762. Published online 2023 Oct 16. doi: 10.3389/fimmu.2023.1254762

PMCID:: PMC10613683

Abstract Article PDF–11M

Select item 986060119.

BMPR2 Variants Underlie Nonsyndromic Oligodontia

Jinglei Zheng, Haochen Liu, Miao Yu, Bichen Lin, Kai Sun, Hangbo Liu, Hailan Feng, Yang Liu, Dong Han

Int J Mol Sci. 2023 Jan; 24(2): 1648. Published online 2023 Jan 13. doi: 10.3390/ijms24021648

PMCID:: PMC9860601

Abstract Article PDF–4.2M

Select item 757184720.

Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling

Anne L. Theilmann, Lindsey G. Hawke, L. Rhiannon Hilton, Mara K.M. Whitford, Devon V. Cole, Jodi L. Mackeil, Kimberly J. Dunham-Snary, Jeffrey Mewburn, Paula D. James, Donald H. Maurice, Stephen L. Archer, Mark L. Ormiston

Arterioscler Thromb Vasc Biol. 2020 Nov; 40(11): 2605–2618. Published online 2020 Oct 1. doi: 10.1161/ATVBAHA.119.313357

PMCID:: PMC7571847

Abstract Article PDF–2.0M

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