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Select item 66282451.

The activin receptor is stimulated in the skeleton, vasculature, heart and kidney during chronic kidney disease.

Matthew J. Williams, Toshifumi Sugatani, Olga A. Agapova, Yifu Fang, Joseph P. Gaut, Marie-Claude Faugere, Hartmut H. Malluche, Keith A. Hruska

Kidney Int. Author manuscript; available in PMC 2019 Jul 15.

Published in final edited form as: Kidney Int. 2018 Jan; 93(1): 147–158. Published online 2017 Aug 23. doi: 10.1016/j.kint.2017.06.016

PMCID:: PMC6628245

Abstract Article PDF–956K

Select item 49607082.

ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments

Shinji Hatakeyama, Serge Summermatter, Marie Jourdain, Stefan Melly, Giulia C. Minetti, Estelle Lach-Trifilieff

Skelet Muscle. 2016; 6: 26. Published online 2016 Jul 26. doi: 10.1186/s13395-016-0098-2

PMCID:: PMC4960708

Abstract Article PDF–1004K

Select item 87487553.

The m⁶A methyltransferase METTL3 regulates muscle maintenance and growth in mice

Jennifer M. Petrosino, Scott A. Hinger, Volha A. Golubeva, Juan M. Barajas, Lisa E. Dorn, Chitra C. Iyer, Hui-Lung Sun, W. David Arnold, Chuan He, Federica Accornero

Nat Commun. 2022; 13: 168. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27848-7

PMCID:: PMC8748755

Abstract Article PDF–2.2M

Select item 59799354.

Adenovirus-mediated knockdown of activin A receptor type 2A attenuates immune-induced hepatic fibrosis in mice and inhibits interleukin-17-induced activation of primary hepatic stellate cells

Hongjun Zhang, Baoling Ju, Ying Nie, Baohui Song, Yuanhong Xu, Ping Gao

Int J Mol Med. 2018 Jul; 42(1): 279–289. Published online 2018 Mar 29. doi: 10.3892/ijmm.2018.3600

PMCID:: PMC5979935

Abstract Article PDF–1.6M

Select item 55665335.

Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass

Brian C. Goh, Vandana Singhal, Angelica J. Herrera, Ryan E. Tomlinson, Soohyun Kim, Marie-Claude Faugere, Emily L. Germain-Lee, Thomas L. Clemens, Se-Jin Lee, Douglas J. DiGirolamo

J Biol Chem. 2017 Aug 18; 292(33): 13809–13822. Published online 2017 Jun 28. doi: 10.1074/jbc.M117.782128

PMCID:: PMC5566533

Abstract Article PDF–3.1M

Select item 34612506.

A PAIR OF TRANSMEMBRANE RECEPTORS ESSENTIAL FOR THE RETENTION AND PIGMENTATION OF HAIR

Rong Han, Hideyuki Beppu, Yun-Kyoung Lee, Katia Georgopoulos, Lionel Larue, En Li, Lorin Weiner, Janice L. Brissette

Genesis. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Genesis. 2012 Nov; 50(11): 783–800. Published online 2012 Jun 19. doi: 10.1002/dvg.22039

PMCID:: PMC3461250

Abstract Article PDF–11M

Select item 27882257.

ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis

Jeanette C. Perron, Jane Dodd

PLoS One. 2009; 4(12): e8198. Published online 2009 Dec 8. doi: 10.1371/journal.pone.0008198

PMCID:: PMC2788225

Abstract Article PDF–1022K

Select item 42640318.

A miR-590/Acvr2a/Rad51b Axis Regulates DNA Damage Repair during mESC Proliferation

Qidong Liu, Guiying Wang, Yafang Chen, Guoping Li, Dandan Yang, Jiuhong Kang

Stem Cell Reports. 2014 Dec 9; 3(6): 1103–1117. Published online 2014 Nov 20. doi: 10.1016/j.stemcr.2014.10.006

PMCID:: PMC4264031

Abstract Article PDF–3.8M

Select item 39926619.

Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice

Huizhen Wang, Melissa Larson, Albina Jablonka-Shariff, Christopher A. Pearl, William L. Miller, P. Michael Conn, Irving Boime, T. Rajendra Kumar

Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15): 5735–5740. Published online 2014 Mar 31. doi: 10.1073/pnas.1321404111

PMCID:: PMC3992661

Abstract Article PDF–1.2M

Select item 370009110.

Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation

Jana Bagarova, Ashley J. Vonner, Kelli A. Armstrong, Jan Börgermann, Carol S. C. Lai, Donna Y. Deng, Hideyuki Beppu, Ivan Alfano, Panagis Filippakopoulos, Nicholas W. Morrell, Alex N. Bullock, Petra Knaus, Yuji Mishina, Paul B. Yu

Mol Cell Biol. 2013 Jun; 33(12): 2413–2424. doi: 10.1128/MCB.01595-12

Correction in:: Mol Cell Biol. 2017 Oct 1; 37(19): e00284-17.

PMCID:: PMC3700091

Abstract Article PDF–2.3M

Select item 789405511.

Development of a Highly Sensitive ELISA for Measurement of FSH in Serum, Plasma, and Whole Blood in Mice

Luisina Ongaro, Carlos Agustin Isidro Alonso, Xiang Zhou, Emilie Brûlé, Yining Li, Gauthier Schang, Albert F Parlow, Frederik Steyn, Daniel J Bernard

Endocrinology. 2021 Apr; 162(4): bqab014. Published online 2021 Jan 21. doi: 10.1210/endocr/bqab014

PMCID:: PMC7894055

Abstract Article

Select item 728662112.

Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B

Gauthier Schang, Luisina Ongaro, Hailey Schultz, Ying Wang, Xiang Zhou, Emilie Brûlé, Ulrich Boehm, Se-Jin Lee, Daniel J Bernard

Endocrinology. 2020 Jul; 161(7): bqaa056. Published online 2020 Apr 9. doi: 10.1210/endocr/bqaa056

PMCID:: PMC7286621

Abstract Article

Select item 418654013.

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

Claire Mayeur, Patricio A. Leyton, Starsha A. Kolodziej, Binglan Yu, Kenneth D. Bloch

Blood. 2014 Sep 25; 124(13): 2116–2123. Prepublished online 2014 Jul 29. doi: 10.1182/blood-2014-04-572644

PMCID:: PMC4186540

Abstract Article

Select item 145680514.

Structure of the ternary signaling complex of a TGF-β superfamily member

George P. Allendorph, Wylie W. Vale, Senyon Choe

Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7643–7648. Published online 2006 May 3. doi: 10.1073/pnas.0602558103

PMCID:: PMC1456805

Abstract Article PDF–2.2M

Select item 130679315.

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

Se-Jin Lee, Lori A. Reed, Monique V. Davies, Stefan Girgenrath, Mary E. P. Goad, Kathy N. Tomkinson, Jill F. Wright, Christopher Barker, Gregory Ehrmantraut, James Holmstrom, Betty Trowell, Barry Gertz, Man-Shiow Jiang, Suzanne M. Sebald, Martin Matzuk, En Li, Li-fang Liang, Edwin Quattlebaum, Ronald L. Stotish, Neil M. Wolfman

Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50): 18117–18122. Published online 2005 Dec 5. doi: 10.1073/pnas.0505996102

PMCID:: PMC1306793

Abstract Article PDF–475K

Select item 837994616.

Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway

Yewei Liu, Adam Lehar, Renata Rydzik, Harshpreet Chandok, Yun-Sil Lee, Daniel W. Youngstrom, Joshy George, Martin M. Matzuk, Emily L. Germain-Lee, Se-Jin Lee

Proc Natl Acad Sci U S A. 2021 Aug 17; 118(33): e2111401118. Published online 2021 Aug 12. doi: 10.1073/pnas.2111401118

PMCID:: PMC8379946

Abstract Article PDF–1.8M

Select item 818493817.

Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis

Diana Monsivais, Takashi Nagashima, Renata Prunskaite-Hyyryläinen, Kaori Nozawa, Keisuke Shimada, Suni Tang, Clark Hamor, Julio E. Agno, Fengju Chen, Ramya P. Masand, Steven L. Young, Chad J. Creighton, Francesco J. DeMayo, Masahito Ikawa, Se-Jin Lee, Martin M. Matzuk

Nat Commun. 2021; 12: 3386. Published online 2021 Jun 7. doi: 10.1038/s41467-021-23571-5

PMCID:: PMC8184938

Abstract Article PDF–18M

Select item 18747218.

Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

S. Paul Oh, Chang-Yeol Yeo, Youngjae Lee, Heindrich Schrewe, Malcolm Whitman, En Li

Genes Dev. 2002 Nov 1; 16(21): 2749–2754. doi: 10.1101/gad.1021802

PMCID:: PMC187472

Abstract Article PDF–262K

Select item 270521219.

A New Model for Growth Factor Activation: Type II Receptors Compete with the Prodomain for BMP-7

Gerhard Sengle, Robert N. Ono, Karen M. Lyons, Hans Peter Bächinger, Lynn Y. Sakai

J Mol Biol. Author manuscript; available in PMC 2009 Jul 2.

Published in final edited form as: J Mol Biol. 2008 Sep 12; 381(4): 1025–1039. Published online 2008 Jul 2. doi: 10.1016/j.jmb.2008.06.074

PMCID:: PMC2705212

Abstract Article PDF–1.9M

Select item 262108720.

Dicer Is Required for Maintaining Adult Pancreas

Sumiyo Morita, Akemi Hara, Itaru Kojima, Takuro Horii, Mika Kimura, Tadahiro Kitamura, Takahiro Ochiya, Katsumi Nakanishi, Ryo Matoba, Kenichi Matsubara, Izuho Hatada

PLoS One. 2009; 4(1): e4212. Published online 2009 Jan 16. doi: 10.1371/journal.pone.0004212