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Select item 96557121.

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Eunice Sze Yin Ng, Nermin Kady, Jane Hu, Arpita Dave, Zhichun Jiang, Jacqueline Pei, Michael B. Gorin, Anna Matynia, Roxana A. Radu

Cells. 2022 Nov; 11(21): 3462. Published online 2022 Nov 2. doi: 10.3390/cells11213462

PMCID:: PMC9655712

Abstract Article PDF–5.3M

Select item 83551112.

In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium

Ratheesh K. Meleppat, Kaitryn E. Ronning, Sarah J. Karlen, Marie E. Burns, Edward N. Pugh, Jr., Robert J. Zawadzki

Sci Rep. 2021; 11: 16252. Published online 2021 Aug 10. doi: 10.1038/s41598-021-95320-z

PMCID:: PMC8355111

Abstract Article PDF–4.4M

Select item 76976833.

Cell-Type-Specific Complement Profiling in the ABCA4^−/− Mouse Model of Stargardt Disease

Yassin Jabri, Josef Biber, Nundehui Diaz-Lezama, Antje Grosche, Diana Pauly

Int J Mol Sci. 2020 Nov; 21(22): 8468. Published online 2020 Nov 11. doi: 10.3390/ijms21228468

PMCID:: PMC7697683

Abstract Article PDF–3.8M

Select item 76451674.

In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging

Ratheesh K. Meleppat, Kaitryn E. Ronning, Sarah J. Karlen, Karuna K. Kothandath, Marie E. Burns, Edward N. Pugh, Jr., Robert J. Zawadzki

Invest Ophthalmol Vis Sci. 2020 Nov; 61(13): 1. Published online 2020 Nov 2. doi: 10.1167/iovs.61.13.1

PMCID:: PMC7645167

Abstract Article PDF–4.5M

Select item 66402655.

Oral Delivery of the P2Y₁₂ Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4^−/− Mouse Model of Retinal Degeneration

Wennan Lu, Keith E. Campagno, Huen-Yee Tso, Aurora Cenaj, Alan M. Laties, Leif G. Carlsson, Claire H. Mitchell

Invest Ophthalmol Vis Sci. 2019 Jul; 60(8): 3046–3053. doi: 10.1167/iovs.19-27241

PMCID:: PMC6640265

Abstract Article PDF–930K

Select item 61303446.

Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

Gulpreet Kaur, Li Xuan Tan, Gurugirijha Rathnasamy, Nilsa La Cunza, Colin J. Germer, Kimberly A. Toops, Marie Fernandes, Timothy A. Blenkinsop, Aparna Lakkaraju

Proc Natl Acad Sci U S A. 2018 Sep 4; 115(36): 9014–9019. Published online 2018 Aug 20. doi: 10.1073/pnas.1805039115

PMCID:: PMC6130344

Abstract Article PDF–2.1M

Select item 59170647.

The P2Y₁₂ Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4^-/- Mouse Model of Retinal Degeneration

Wennan Lu, Néstor M. Gómez, Jason C. Lim, Sonia Guha, Ann O’Brien-Jenkins, Erin E. Coffey, Keith E. Campagno, Stuart A. McCaughey, Alan M. Laties, Leif G. Carlsson, Claire H. Mitchell

Front Pharmacol. 2018; 9: 242. Published online 2018 Apr 19. doi: 10.3389/fphar.2018.00242

PMCID:: PMC5917064

Abstract Article PDF–2.1M

Select item 58862648.

Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration

Laurie L Molday, Daniel Wahl, Marinko V Sarunic, Robert S Molday

Hum Mol Genet. 2018 Jan 15; 27(2): 295–306. Published online 2017 Nov 14. doi: 10.1093/hmg/ddx400

PMCID:: PMC5886264

Abstract Article PDF–1.0M

Select item 57254629.

Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas

David M. G. Anderson, Zsolt Ablonczy, Yiannis Koutalos, Anne M. Hanneken, Jeffrey M. Spraggins, M. Wade Calcutt, Rosalie K. Crouch, Richard M. Caprioli, Kevin L. Schey

Sci Rep. 2017; 7: 17352. Published online 2017 Dec 11. doi: 10.1038/s41598-017-17402-1

PMCID:: PMC5725462

Abstract Article PDF–2.4M

Select item 497829610.

Protective responses to sublytic complement in the retinal pigment epithelium

Li Xuan Tan, Kimberly A. Toops, Aparna Lakkaraju

Proc Natl Acad Sci U S A. 2016 Aug 2; 113(31): 8789–8794. Published online 2016 Jul 18. doi: 10.1073/pnas.1523061113

PMCID:: PMC4978296

Abstract Article PDF–1.6M

Select item 463438111.

Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease

Ivana Trapani, Elisabetta Toriello, Sonia de Simone, Pasqualina Colella, Carolina Iodice, Elena V. Polishchuk, Andrea Sommella, Linda Colecchi, Settimio Rossi, Francesca Simonelli, Massimo Giunti, Maria L. Bacci, Roman S. Polishchuk, Alberto Auricchio

Hum Mol Genet. 2015 Dec 1; 24(23): 6811–6825. Published online 2015 Sep 29. doi: 10.1093/hmg/ddv386

PMCID:: PMC4634381

Abstract Article PDF–680K

Select item 450028512.

Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization

Peter Charbel Issa, Alun R. Barnard, Philipp Herrmann, Ilyas Washington, Robert E. MacLaren

Proc Natl Acad Sci U S A. 2015 Jul 7; 112(27): 8415–8420. Published online 2015 Jun 23. doi: 10.1073/pnas.1506960112

PMCID:: PMC4500285

Abstract Article PDF–1.1M

Select item 443024113.

Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity

Claes Bavik, Susan Hayes Henry, Yan Zhang, Kyoko Mitts, Tim McGinn, Ewa Budzynski, Andriy Pashko, Kuo Lee Lieu, Sheng Zhong, Bruce Blumberg, Vladimir Kuksa, Mark Orme, Ian Scott, Ahmad Fawzi, Ryo Kubota

PLoS One. 2015; 10(5): e0124940. Published online 2015 May 13. doi: 10.1371/journal.pone.0124940

PMCID:: PMC4430241

Abstract Article PDF–1.6M

Select item 380475414.

Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor

Sonia Guha, Gabriel C. Baltazar, Erin E. Coffey, Leigh-Anne Tu, Jason C. Lim, Jonathan M. Beckel, Shaun Patel, Thor Eysteinsson, Wennan Lu, Ann O'Brien-Jenkins, Alan M. Laties, Claire H. Mitchell

FASEB J. 2013 Nov; 27(11): 4500–4509. doi: 10.1096/fj.13-236166

PMCID:: PMC3804754

Abstract Article

Select item 374771615.

Fundus Autofluorescence in the Abca4^−/− Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and Histology

Peter Charbel Issa, Alun R. Barnard, Mandeep S. Singh, Emma Carter, Zhichun Jiang, Roxana A. Radu, Ulrich Schraermeyer, Robert E. MacLaren

Invest Ophthalmol Vis Sci. 2013 Aug; 54(8): 5602–5612. Published online 2013 Aug 19. doi: 10.1167/iovs.13-11688

PMCID:: PMC3747716

Abstract Article PDF–895K

Select item 363226916.

Quantitative Fundus Autofluorescence in Mice: Correlation With HPLC Quantitation of RPE Lipofuscin and Measurement of Retina Outer Nuclear Layer Thickness

Janet R. Sparrow, Anna Blonska, Erin Flynn, Tobias Duncker, Jonathan P. Greenberg, Roberta Secondi, Keiko Ueda, François C. Delori

Invest Ophthalmol Vis Sci. 2013 Apr; 54(4): 2812–2820. Published online 2013 Apr 17. doi: 10.1167/iovs.12-11490

Correction in:: Invest Ophthalmol Vis Sci. 2014 Oct; 55(10): 6711.

PMCID:: PMC3632269

Abstract Article PDF–654K

Select item 354442417.

A1120, a Nonretinoid RBP4 Antagonist, Inhibits Formation of Cytotoxic Bisretinoids in the Animal Model of Enhanced Retinal Lipofuscinogenesis

Nicoleta Dobri, Qiong Qin, Jian Kong, Kazunori Yamamoto, Zhao Liu, Gennadiy Moiseyev, Jian-xing Ma, Rando Allikmets, Janet R. Sparrow, Konstantin Petrukhin

Invest Ophthalmol Vis Sci. 2013 Jan; 54(1): 85–95. Published online 2013 Jan 7. doi: 10.1167/iovs.12-10050

PMCID:: PMC3544424

Abstract Article PDF–617K

Select item 340896018.

Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris

Sonia Guha, Gabriel C. Baltazar, Leigh-Anne Tu, Ji Liu, Jason C. Lim, Wennan Lu, Arthur Argall, Kathleen Boesze-Battaglia, Alan M. Laties, Claire H. Mitchell

J Neurochem. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: J Neurochem. 2012 Aug; 122(4): 823–833. Published online 2012 Jun 27. doi: 10.1111/j.1471-4159.2012.07804.x