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Select item 110034601.

PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS

Issa O. Yusuf, Sepideh Parsi, Lyle W. Ostrow, Robert H. Brown, Paul R. Thompson, Zuoshang Xu

Neurobiol Dis. Author manuscript; available in PMC 2024 Apr 9.

Published in final edited form as: Neurobiol Dis. 2024 Mar; 192: 106414. Published online 2024 Jan 21. doi: 10.1016/j.nbd.2024.106414

PMCID:: PMC11003460

Abstract Article PDF–5.8M

Select item 94552462.

Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis

Laura Massarenti, Christian Enevold, Dres Damgaard, Peter Riis Hansen, Morten Frisch, Niels Ødum, Søren Jacobsen, Claus Henrik Nielsen

Int J Mol Sci. 2022 Sep; 23(17): 9536. Published online 2022 Aug 23. doi: 10.3390/ijms23179536

PMCID:: PMC9455246

Abstract Article PDF–853K

Select item 92609583.

Molecular Mechanism of Protein Arginine Deiminase 2: A Study Involving Multiple Microsecond Long Molecular Dynamics Simulations

Erdem Cicek, Gerald Monard, Fethiye Aylin Sungur

Biochemistry. 2022 Jul 5; 61(13): 1286–1297. Published online 2022 Jun 23. doi: 10.1021/acs.biochem.2c00158

PMCID:: PMC9260958

Abstract Article PDF–5.6M

Select item 83717074.

PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico

Iris Paola Guzmán-Guzmán, Claudia Isabel Ramírez-Vélez, Ramcés Falfán-Valencia, José Eduardo Navarro-Zarza, Ilse Adriana Gutiérrez-Pérez, Oscar Zaragoza-García, Mónica Ramírez, Natividad Castro-Alarcón, Isela Parra-Rojas

Front Immunol. 2021; 12: 718246. Published online 2021 Aug 4. doi: 10.3389/fimmu.2021.718246

PMCID:: PMC8371707

Abstract Article PDF–548K

Select item 74608085.

The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage

Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu

Int J Mol Sci. 2020 Aug; 21(16): 5720. Published online 2020 Aug 10. doi: 10.3390/ijms21165720

PMCID:: PMC7460808

Abstract Article PDF–2.5M

Select item 70729596.

Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer

Miguel Beato, Priyanka Sharma

Int J Mol Sci. 2020 Feb; 21(4): 1351. Published online 2020 Feb 17. doi: 10.3390/ijms21041351

PMCID:: PMC7072959

Abstract Article PDF–1.4M

Select item 67858967.

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu, Xuesen Zhang

J Exp Clin Cancer Res. 2019; 38: 414. Published online 2019 Oct 10. doi: 10.1186/s13046-019-1404-8

PMCID:: PMC6785896

Abstract Article PDF–11M

Select item 66915078.

Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2

Li Zheng, Mitesh Nagar, Aaron J. Maurais, Daniel J. Slade, Sangram S. Parelkar, Scott A. Coonrod, Eranthie Weerapana, Paul R. Thompson

Biochemistry. Author manuscript; available in PMC 2020 Jul 9.

Published in final edited form as: Biochemistry. 2019 Jul 9; 58(27): 3042–3056. Published online 2019 Jun 27. doi: 10.1021/acs.biochem.9b00225

PMCID:: PMC6691507

Abstract Article PDF–984K

Select item 54065349.

Protein‐arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination

Ryo Funayama, Hajime Taniguchi, Masamichi Mizuma, Fumiyoshi Fujishima, Minoru Kobayashi, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama

Cancer Sci. 2017 Apr; 108(4): 713–718. Published online 2017 Apr 12. doi: 10.1111/cas.13179

PMCID:: PMC5406534

Abstract Article PDF–785K

Select item 429808510.

Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

Dres Damgaard, Ladislav Senolt, Michael Friberg Nielsen, Ger J Pruijn, Claus H Nielsen

Arthritis Res Ther. 2014; 16(6): 498. Published online 2014 Dec 5. doi: 10.1186/s13075-014-0498-9

PMCID:: PMC4298085

Abstract Article PDF–674K

Select item 410078111.

Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-Assisted Mechanism

Christina J. Dreyton, Bryan Knuckley, Justin E. Jones, Daniel M. Lewallen, Paul R. Thompson

Biochemistry. 2014 Jul 15; 53(27): 4426–4433. Published online 2014 Jul 3. doi: 10.1021/bi500554b

PMCID:: PMC4100781

Abstract Article PDF–1.1M

Select item 368398112.

RETINAL DEIMINATION AND PAD2 LEVELS IN RETINAS FROM DONORS WITH AGE-RELATED MACULAR DEGENERATION (AMD)

Vera L. Bonilha, Karen G. Shadrach, Mary E. Rayborn, Yong Li, Gayle J. T. Pauer, Stephanie A. Hagstrom, Sanjoy K. Bhattacharya, Joe G. Hollyfield

Exp Eye Res. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Exp Eye Res. 2013 Jun; 111: 71–78. Published online 2013 Apr 3. doi: 10.1016/j.exer.2013.03.017

PMCID:: PMC3683981

Abstract Article PDF–4.0M

Select item 360904913.

Peptidylarginine deiminase and protein citrullination in prion diseases: Strong evidence of neurodegeneration

Byungki Jang, Akihito Ishigami, Naoki Maruyama, Richard I. Carp, Yong-Sun Kim, Eun-Kyoung Choi

Prion. 2013 Jan 1; 7(1): 42–46. doi: 10.4161/pri.22380

PMCID:: PMC3609049

Abstract Article PDF–729K

Select item 340406014.

Potential Role for PAD2 in Gene Regulation in Breast Cancer Cells

Brian D. Cherrington, Xuesen Zhang, John L. McElwee, Eric Morency, Lynne J. Anguish, Scott A. Coonrod

PLoS One. 2012; 7(7): e41242. Published online 2012 Jul 24. doi: 10.1371/journal.pone.0041242

PMCID:: PMC3404060

Abstract Article PDF–9.7M

Select item 292737015.

Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve

Thamara A. Cafaro, Stefanía Santo, Lucena A. Robles, Nicolás Crim, Julio A. Urrets-Zavalia, Horacio M. Serra

Mol Vis. 2010; 16: 1654–1658. Published online 2010 Aug 17.

PMCID:: PMC2927370

Abstract Article PDF–1.8M

Select item 179462416.

The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple Sclerosis

Mario A. Moscarello, Fabrizio G. Mastronardi, D. Denise Wood

Neurochem Res. 2007 Feb; 32(2): 251–256. Published online 2006 Sep 22. doi: 10.1007/s11064-006-9144-5

PMCID:: PMC1794624

Abstract Article PDF–188K

Select item 1052744117.

Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients

Karol J. Nava-Quiroz, Jorge Rojas-Serrano, Gloria Pérez-Rubio, Ivette Buendia-Roldan, Mayra Mejía, Juan Carlos Fernández-López, Pedro Rodríguez-Henríquez, Noé Ayala-Alcantar, Espiridión Ramos-Martínez, Luis Alberto López-Flores, Alma D. Del Ángel-Pablo, Ramcés Falfán-Valencia

Cells. 2023 Sep; 12(18): 2235. Published online 2023 Sep 8. doi: 10.3390/cells12182235

PMCID:: PMC10527441

Abstract Article PDF–1.6M

Select item 898544318.

Proximity-dependent labeling of Cysteines

Sudeshna Sen, Nadia Sultana, Scott A. Shaffer, Paul R. Thompson

J Am Chem Soc. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: J Am Chem Soc. 2021 Nov 24; 143(46): 19257–19261. Published online 2021 Nov 11. doi: 10.1021/jacs.1c07069

PMCID:: PMC8985443

Abstract Article PDF–1.4M

Select item 885728219.

Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts

Konstantin Tsoyi, Anthony J. Esposito, Bo Sun, Ryan G. Bowen, Kevin Xiong, Fernando Poli, Rafael Cardenas, Sarah G. Chu, Xiaoliang Liang, Stefan W. Ryter, Christine Beeton, Tracy J. Doyle, Matthew J. Robertson, Lindsay J. Celada, Freddy Romero, Souheil Y. El-Chemaly, Mark A. Perrella, I.-Cheng Ho, Ivan O. Rosas

Sci Rep. 2022; 12: 2847. Published online 2022 Feb 18. doi: 10.1038/s41598-022-06678-7