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Select item 79610941.

Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins

Samantha J. Wong, Alison E. Ringel, William Yuan, Joao A. Paulo, Haejin Yoon, Mark A. Currie, Marcia C. Haigis

J Biol Chem. 2021 Jan-Jun; 296: 100397. Published online 2021 Feb 8. doi: 10.1016/j.jbc.2021.100397

PMCID:: PMC7961094

Abstract Article PDF–1.4M

Select item 53550712.

Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma

Mingyang Ma, Shuyao Hua, Gang Li, Sumei Wang, Xue Cheng, Songqing He, Ping Wu, Xiaoping Chen

Oncotarget. 2017 Feb 21; 8(8): 12983–13002. Published online 2017 Jan 16. doi: 10.18632/oncotarget.14677

PMCID:: PMC5355071

Abstract Article PDF–7.3M

Select item 41615133.

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Weibo Luo, Benjamin Lin, Yingfei Wang, Jun Zhong, Robert O'Meally, Robert N. Cole, Akhilesh Pandey, Andre Levchenko, Gregg L. Semenza

Mol Biol Cell. 2014 Sep 15; 25(18): 2788–2796. doi: 10.1091/mbc.E14-02-0775

PMCID:: PMC4161513

Abstract Article PDF–3.7M

Select item 38674384.

Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition

Trenton L. Place, Jones T. Nauseef, Maina K. Peterson, Michael D. Henry, James J. Mezhir, Frederick E. Domann

PLoS One. 2013; 8(12): e83021. Published online 2013 Dec 18. doi: 10.1371/journal.pone.0083021

PMCID:: PMC3867438

Abstract Article PDF–3.7M

Select item 35112515.

Construction of a recombinant eukaryotic expression vector containing PHD3 gene and its expression in HepG2 cells

Qi-Lian Liang, Zhou-Yu Li, Yuan Zhou, Qiu-Long Liu, Wen-Ting Ou, Zhi-Gang Huang

J Exp Clin Cancer Res. 2012; 31(1): 64. Published online 2012 Aug 17. doi: 10.1186/1756-9966-31-64

PMCID:: PMC3511251

Abstract Article PDF–1.5M

Select item 33377126.

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

Nan Chen, Oliver Rinner, Dominika Czernik, Katarzyna J Nytko, Dan Zheng, Daniel P Stiehl, Nicola Zamboni, Matthias Gstaiger, Christian Frei

Cell Res. 2011 Jun; 21(6): 983–986. Published online 2011 Apr 12. doi: 10.1038/cr.2011.66

PMCID:: PMC3337712

Article PDF–539K

Select item 32107667.

Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells

Heidi Högel, Krista Rantanen, Terhi Jokilehto, Reidar Grenman, Panu M. Jaakkola

PLoS One. 2011; 6(11): e27112. Published online 2011 Nov 8. doi: 10.1371/journal.pone.0027112

PMCID:: PMC3210766

Abstract Article PDF–1.6M

Select item 30305588.

Aberrant Promoter CpG Methylation Is a Mechanism for Impaired PHD3 Expression in a Diverse Set of Malignant Cells

Trenton L. Place, Matthew P. Fitzgerald, Sujatha Venkataraman, Sabine U. Vorrink, Adam J. Case, Melissa L. T. Teoh, Frederick E. Domann

PLoS One. 2011; 6(1): e14617. Published online 2011 Jan 28. doi: 10.1371/journal.pone.0014617

PMCID:: PMC3030558

Abstract Article PDF–640K

Select item 23668649.

Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation

Krista Rantanen, Juha Pursiheimo, Heidi Högel, Virpi Himanen, Eric Metzen, Panu M. Jaakkola

Mol Biol Cell. 2008 May; 19(5): 2231–2240. doi: 10.1091/mbc.E07-11-1124

PMCID:: PMC2366864

Abstract Article PDF–1.3M

Select item 1089144410.

Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma

Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti

Cancer Med. 2024 Feb; 13(3): e6998. Published online 2024 Feb 24. doi: 10.1002/cam4.6998

PMCID:: PMC10891444

Abstract Article PDF–1.9M

Select item 893328011.

Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth

Ying Jin, Yamu Pan, Shuang Zheng, Yao Liu, Jie Xu, Yazhi Peng, Zemei Zhang, Yadong Wang, Yulian Xiong, Lei Xu, Kaiyu Mu, Suwen Chen, Fei Zheng, Ye Yuan, Jian Fu

Oncogene. 2022; 41(12): 1752–1766. Published online 2022 Feb 5. doi: 10.1038/s41388-022-02203-2

PMCID:: PMC8933280

Abstract Article PDF–8.6M

Select item 800121112.

Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo

Niki M. Zacharias, Lei Wang, Tapati Maity, Li Li, Steven W. Millward, Jose A. Karam, Christopher G. Wood, Neema Navai

Int J Mol Sci. 2021 Mar; 22(6): 2849. Published online 2021 Mar 11. doi: 10.3390/ijms22062849

PMCID:: PMC8001211

Abstract Article PDF–3.2M

Select item 688159113.

Whole-Genome Sequencing Identifies the Egl Nine Homologue 3 (egln3/phd3) and Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 (PPP1R2P1) Associated with High-Altitude Polycythemia in Tibetans at High Altitude

Luobu Gesang, Lamu Gusang, Ciren Dawa, Gawa Gesang, Kang Li

Dis Markers. 2019; 2019: 5946461. Published online 2019 Nov 7. doi: 10.1155/2019/5946461

PMCID:: PMC6881591

Abstract Article PDF–446K

Select item 656550614.

MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer

Yicun Wang, Xin Li, Wei Liu, Bingjin Li, Dongquan Chen, Fengping Hu, Lizhong Wang, Xiaoguang M. Liu, Ranji Cui, Runhua Liu

Oncogene. Author manuscript; available in PMC 2019 Aug 26.

Published in final edited form as: Oncogene. 2019 Jun; 38(24): 4820–4834. Published online 2019 Feb 26. doi: 10.1038/s41388-019-0760-3

PMCID:: PMC6565506

Abstract Article PDF–2.6M

Select item 641642315.

Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma

Petra Miikkulainen, Heidi Högel, Fatemeh Seyednasrollah, Krista Rantanen, Laura L. Elo, Panu M. Jaakkola

J Biol Chem. 2019 Mar 8; 294(10): 3760–3771. Published online 2019 Jan 7. doi: 10.1074/jbc.RA118.004902

PMCID:: PMC6416423

Abstract Article PDF–3.0M

Select item 571658316.

Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis

Gilberto Gastelum, Aleksandra Poteshkina, Mysore Veena, Edgar Artiga, Geraldine Weckstein, Patrick Frost

PLoS One. 2017; 12(12): e0188438. Published online 2017 Dec 5. doi: 10.1371/journal.pone.0188438

PMCID:: PMC5716583

Abstract Article PDF–7.9M

Select item 482360117.

Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion

Mei Huang, Sabina Paglialunga, Julia M.‐K. Wong, Monica Hoang, Renjitha Pillai, Jamie W. Joseph

Physiol Rep. 2016 Mar; 4(5): e12722. Published online 2016 Mar 20. doi: 10.14814/phy2.12722

PMCID:: PMC4823601

Abstract Article PDF–488K

Select item 474163518.

Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions

Oihana Iriondo, Miriam Rábano, Giacomo Domenici, Onintza Carlevaris, José Antonio López-Ruiz, Ignacio Zabalza, Edurne Berra, Maria dM Vivanco

Oncotarget. 2015 Oct 13; 6(31): 31721–31739. Published online 2015 Sep 10. doi: 10.18632/oncotarget.5564

PMCID:: PMC4741635

Abstract Article PDF–1.3M

Select item 456123419.

Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma

Takayuki Tanaka, Tao-Sheng Li, Yoshishige Urata, Shinji Goto, Yusuke Ono, Miho Kawakatsu, Hajime Matsushima, Masataka Hirabaru, Tomohiko Adachi, Amane Kitasato, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi

J Gastroenterol. 2015; 50(9): 975–983. Published online 2014 Dec 27. doi: 10.1007/s00535-014-1030-3