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Select item 111022211.

HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway

Siqi Zhou, Zhangding Wang, Dian Zhao, Yao Fu, Shu Zhang, Zhiping Wang, Xiaoping Zou

World J Surg Oncol. 2024; 22: 133. Published online 2024 May 18. doi: 10.1186/s12957-024-03409-2

PMCID:: PMC11102221

Abstract Article PDF–9.4M

Select item 106059702.

Regulation of HHLA2 expression in kidney cancer and myeloid cells

Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Kathleen M. Mahoney

BMC Cancer. 2023; 23: 1039. Published online 2023 Oct 27. doi: 10.1186/s12885-023-11496-9

PMCID:: PMC10605970

Abstract Article PDF–2.6M

Select item 100573773.

Overexpression and Role of HHLA2, a Novel Immune Checkpoint, in Colorectal Cancer

Agnieszka Kula, Miriam Dawidowicz, Sylwia Mielcarska, Paweł Kiczmer, Hanna Skiba, Małgorzata Krygier, Magdalena Chrabańska, Jerzy Piecuch, Monika Szrot, Julia Robotycka, Błażej Ochman, Bogumiła Strzałkowska, Zenon Czuba, Elżbieta Świętochowska, Dariusz Waniczek

Int J Mol Sci. 2023 Mar; 24(6): 5876. Published online 2023 Mar 20. doi: 10.3390/ijms24065876

PMCID:: PMC10057377

Abstract Article PDF–4.5M

Select item 100304544.

Increased co-expression of stromal HHLA2 and fibroblast activation protein in upper tract urothelial carcinoma

Daisaku Nishihara, Toshiki Kijima, Kyoko Arai, Takao Kamai

Int Urol Nephrol. 2023; 55(4): 867–874. Published online 2023 Jan 4. doi: 10.1007/s11255-022-03458-0

PMCID:: PMC10030454

Abstract Article PDF–1.5M

Select item 99460095.

Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease

Lijuan Xu, Fengsen Li, Min Jiang, Zheng Li, Dan Xu, Jing Jing, Jing Wang, Jianbing Ding

Int J Chron Obstruct Pulmon Dis. 2023; 18: 139–153. Published online 2023 Feb 18. doi: 10.2147/COPD.S394327

PMCID:: PMC9946009

Abstract Article PDF–4.8M

Select item 93951406.

HHLA2 predicts improved prognosis of anti-PD-1/PD-L1 immunotherapy in patients with melanoma

Fu-xue Huang, Jun-wan Wu, Xia-qin Cheng, Jiu-hong Wang, Xi-zhi Wen, Jing-jing Li, Qiong Zhang, Hang Jiang, Qiu-yue Ding, Xiao-feng Zhu, Xiao-shi Zhang, Ya Ding, Dan-dan Li

Front Immunol. 2022; 13: 902167. Published online 2022 Aug 8. doi: 10.3389/fimmu.2022.902167

PMCID:: PMC9395140

Abstract Article PDF–4.6M

Select item 93744687.

HHLA2 promotes tumor progression by long non-coding RNA H19 in human gallbladder cancer

Yizhou Zhang, Hanrong Li, Chao Lv, Baokang Wu, Yang Yu, Chongli Zhong, Qi Lang, Zhiyun Liang, Yang Li, Yu Shi, Jian Zhang, Feng Xu, Yu Tian

Int J Oncol. 2022 Sep; 61(3): 112. Published online 2022 Aug 1. doi: 10.3892/ijo.2022.5402

PMCID:: PMC9374468

Abstract Article PDF–2.0M

Select item 90356288.

Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy

Honggang Ying, Jian Xu, Xiaozhen Zhang, Tingbo Liang, Xueli Bai

EBioMedicine. 2022 May; 79: 103987. Published online 2022 Apr 16. doi: 10.1016/j.ebiom.2022.103987

PMCID:: PMC9035628

Abstract Article PDF–657K

Select item 89686429.

Comprehensive Analysis of HHLA2 as a Prognostic Biomarker and Its Association With Immune Infiltrates in Hepatocellular Carcinoma

Lin Ding, Qian Yu, Shuo Yang, Wen-Jing Yang, Te Liu, Jing-Rong Xian, Tong-Tong Tian, Tong Li, Wei Chen, Bei-Li Wang, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo

Front Immunol. 2022; 13: 831101. Published online 2022 Mar 17. doi: 10.3389/fimmu.2022.831101

PMCID:: PMC8968642

Abstract Article PDF–11M

Select item 833581310.

HHLA2 deficiency inhibits non‐small cell lung cancer progression and THP‐1 macrophage M2 polarization

Wenjie Sun, Shuying Li, Guiliang Tang, Shaoxing Sun, Yuan Luo, Rui Bai, Linzhi Han, Xueping Jiang, Yanping Gao, Zhengrong Huang, Junhong Zhang, Yan Gong, Conghua Xie

Cancer Med. 2021 Aug; 10(15): 5256–5269. Published online 2021 Jun 21. doi: 10.1002/cam4.4081

Correction in:: Cancer Med. 2024 May; 13(9): e7205.

PMCID:: PMC8335813

Abstract Article PDF–3.1M

Select item 832249911.

Prognostic value of HHLA2 expression in solid tumors: A meta-analysis based on the Chinese population

Chuanmeng Zhang, Jie Xu, Jun Ye, Xiaohong Zhang

Medicine (Baltimore) 2021 Jul 30; 100(30): e26789. Published online 2021 Jul 30. doi: 10.1097/MD.0000000000026789

PMCID:: PMC8322499

Abstract Article PDF–560K

Select item 820507412.

B7-H7 Is Inducible on T Cells to Regulate Their Immune Response and Serves as a Marker for Exhaustion

Khang Luu, Herbert Schwarz, Andreas Lundqvist

Front Immunol. 2021; 12: 682627. Published online 2021 Jun 1. doi: 10.3389/fimmu.2021.682627

PMCID:: PMC8205074

Abstract Article PDF–2.9M

Select item 816695313.

B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

Sadiye Amcaoglu Rieder, Jingya Wang, Natalie White, Ariful Qadri, Catherine Menard, Geoffrey Stephens, Jodi L. Karnell, Christopher E. Rudd, Roland Kolbeck

Cell Mol Immunol. 2021 Jun; 18(6): 1503–1511. Published online 2020 Jan 31. doi: 10.1038/s41423-020-0361-7

PMCID:: PMC8166953

Abstract Article PDF–1.2M

Select item 813258514.

H Long Terminal Repeat-Associating 2 (HHLA2) is a Biomarker of Advanced Stage Hepatocellular Carcinoma and Promotes Tumor Cell Development In Vitro

Min Luo, Yao Xiong, Yan Lin, Rong Liang, Yongqiang Li, Lianying Ge

Med Sci Monit. 2021; 27: e930215-1–e930215-11. Prepublished online 2021 Feb 26. Published online 2021 May 15. doi: 10.12659/MSM.930215

PMCID:: PMC8132585

Abstract Article PDF–3.3M

Select item 705744115.

HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma

Qiang-Hua Zhou, Kai-Wen Li, Xu Chen, Hai-Xia He, Sheng-Meng Peng, Shi-Rong Peng, Qiong Wang, Ze-An Li, Yi-Ran Tao, Wen-Li Cai, Ran-Yi Liu, Hai Huang

J Immunother Cancer. 2020; 8(1): e000157. Published online 2020 Jan 19. doi: 10.1136/jitc-2019-000157

Correction in:: J Immunother Cancer. 2020; 8(1): e000157corr1.

PMCID:: PMC7057441

Abstract Article PDF–3.1M

Select item 682630916.

HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma

Yangzhi Qi, Gang Deng, Pengfei Xu, Huikai Zhang, Fanen Yuan, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Chen

Oncol Rep. 2019 Dec; 42(6): 2309–2322. Published online 2019 Oct 1. doi: 10.3892/or.2019.7343

Correction in:: Oncol Rep. 2023 Feb; 49(2): 36.

PMCID:: PMC6826309

Abstract Article PDF–1.9M

Select item 642167617.

HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing, Yi-Peng Fu, Yong Yi, Mei-Xia Zhang, Su-Su Zheng, Jin-Long Huang, Wei Gan, Xin Xu, Jia-Jia Lin, Juan Zhang, Shuang-Jian Qiu, Bo-Heng Zhang

J Immunother Cancer. 2019; 7: 77. Published online 2019 Mar 18. doi: 10.1186/s40425-019-0554-8

PMCID:: PMC6421676

Abstract Article PDF–4.3M

Select item 635796218.

HHLA2 is a Novel Immune Checkpoint Protein in Pancreatic Ductal Adenocarcinoma and Predicts Post-surgical Survival

Han Yan, Wanglong Qiu, Anne K. Koehne de Gonzalez, Ji-Shu Wei, Min Tu, Chun-Hua Xi, Ye-Ran Yang, Yun-Peng Peng, Wei-Yann Tsai, Helen E. Remotti, Yi Miao, Gloria H. Su

Cancer Lett. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Cancer Lett. 2019 Feb 1; 442: 333–340. Published online 2018 Nov 14. doi: 10.1016/j.canlet.2018.11.007

PMCID:: PMC6357962

Abstract Article PDF–3.0M

Select item 595513119.

The association of human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) expression with gastric cancer prognosis

Masataka Shimonosono, Takaaki Arigami, Shigehiro Yanagita, Daisuke Matsushita, Yasuto Uchikado, Yuko Kijima, Hiroshi Kurahara, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Itaru Omoto, Kosei Maemura, Yoshikazu Uenosono, Sumiya Ishigami, Shoji Natsugoe

Oncotarget. 2018 Apr 24; 9(31): 22069–22078. Published online 2018 Apr 24. doi: 10.18632/oncotarget.25179