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Select item 33772681.

Role of the WNK-activated SPAK kinase in regulating blood pressure

Fatema H Rafiqi, Annie Mercier Zuber, Mark Glover, Ciaran Richardson, Stewart Fleming, Sofija Jovanović, Aleksandar Jovanović, Kevin M O'Shaughnessy, Dario R Alessi

EMBO Mol Med. 2010 Feb; 2(2): 63–75. doi: 10.1002/emmm.200900058

PMCID:: PMC3377268

Abstract Article PDF–738K

Select item 13469132.

Characterization of SPAK and OSR1, Regulatory Kinases of the Na-K-2Cl Cotransporter

Kenneth B. E. Gagnon, Roger England, Eric Delpire

Mol Cell Biol. 2006 Jan; 26(2): 689–698. doi: 10.1128/MCB.26.2.689-698.2006

PMCID:: PMC1346913

Abstract Article PDF–416K

Select item 63789663.

Regulation of erythrocyte Na⁺/K⁺/2Cl⁻ cotransport by an oxygen-switched kinase cascade

Suilan Zheng, Nathan A. Krump, Mary M. McKenna, Yen-Hsing Li, Anke Hannemann, Lisa J. Garrett, John S. Gibson, David M. Bodine, Philip S. Low

J Biol Chem. 2019 Feb 15; 294(7): 2519–2528. Published online 2018 Dec 18. doi: 10.1074/jbc.RA118.006393

PMCID:: PMC6378966

Abstract Article PDF–2.3M

Select item 53814504.

Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke

Hanshu Zhao, Rachel Nepomuceno, Xin Gao, Lesley M Foley, Shaoxia Wang, Gulnaz Begum, Wen Zhu, Victoria M Pigott, Lindsay M Falgoust, Kristopher T Kahle, Sung-Sen Yang, Shih-Hua Lin, Seth L Alper, T Kevin Hitchens, Shaoshan Hu, Zhongling Zhang, Dandan Sun

J Cereb Blood Flow Metab. 2017 Feb; 37(2): 550–563. Published online 2016 Feb 9. doi: 10.1177/0271678X16631561

PMCID:: PMC5381450

Abstract Article PDF–1.8M

Select item 51125615.

OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis

Yung-Liang Liu, Sung-Sen Yang, Shyi-Jou Chen, Yu-Chun Lin, Chin-Chen Chu, Hsin-Hui Huang, Fung-Wei Chang, Mu-Hsien Yu, Shih-Hua Lin, Gwo-Jang Wu, Huey-Kang Sytwu

Sci Rep. 2016; 6: 37205. Published online 2016 Nov 17. doi: 10.1038/srep37205

PMCID:: PMC5112561

Abstract Article PDF–2.6M

Select item 50097676.

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule

Mohammed Z. Ferdaus, Karl W. Barber, Karen I. López‐Cayuqueo, Andrew S. Terker, Eduardo R. Argaiz, Brandon M. Gassaway, Régine Chambrey, Gerardo Gamba, Jesse Rinehart, James A. McCormick

J Physiol. 2016 Sep 1; 594(17): 4945–4966. Published online 2016 May 29. doi: 10.1113/JP272311

PMCID:: PMC5009767

Abstract Article PDF–1.0M

Select item 37706387.

SPAK Deficiency Corrects Pseudohypoaldosteronism II Caused by WNK4 Mutation

Pei-Yi Chu, Chih-Jen Cheng, Yi-Chang Wu, Yu-Wei Fang, Tom Chau, Shinichi Uchida, Sei Sasaki, Sung-Sen Yang, Shih-Hua Lin

PLoS One. 2013; 8(9): e72969. Published online 2013 Sep 11. doi: 10.1371/journal.pone.0072969

PMCID:: PMC3770638

Abstract Article PDF–5.6M

Select item 34880448.

SPAK Isoforms and OSR1 Regulate Sodium-Chloride Co-transporters in a Nephron-specific Manner

P. Richard Grimm, Tarvinder K. Taneja, Jie Liu, Richard Coleman, Yang-Yi Chen, Eric Delpire, James B. Wade, Paul A. Welling

J Biol Chem. 2012 Nov 2; 287(45): 37673–37690. Published online 2012 Sep 12. doi: 10.1074/jbc.M112.402800

PMCID:: PMC3488044

Abstract Article PDF–5.3M

Select item 28519199.

Molecular components of signal amplification in olfactory sensory cilia

Thomas Hengl, Hiroshi Kaneko, Kristin Dauner, Kerstin Vocke, Stephan Frings, Frank Möhrlen

Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13): 6052–6057. Published online 2010 Mar 15. doi: 10.1073/pnas.0909032107

PMCID:: PMC2851919

Abstract Article PDF–795K

Select item 433276910.

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride

Andrew S. Terker, Chong Zhang, James A. McCormick, Rebecca A. Lazelle, Chengbiao Zhang, Nicholas P. Meermeier, Dominic A. Siler, Hae J. Park, Yi Fu, David M. Cohen, Alan M. Weinstein, Wen-Hui Wang, Chao-Ling Yang, David H. Ellison

Cell Metab. Author manuscript; available in PMC 2016 Jan 6.

Published in final edited form as: Cell Metab. 2015 Jan 6; 21(1): 39–50. doi: 10.1016/j.cmet.2014.12.006

PMCID:: PMC4332769

Abstract Article PDF–720K

Select item 319837911.

Impaired phosphorylation of Na⁺-K⁺-2Cl⁻ cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

Shih-Hua Lin, I-Shing Yu, Si-Tse Jiang, Shu-Wha Lin, Pauling Chu, Ann Chen, Huey-Kang Sytwu, Eisei Sohara, Shinichi Uchida, Sei Sasaki, Sung-Sen Yang

Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42): 17538–17543. Published online 2011 Oct 4. doi: 10.1073/pnas.1107452108

PMCID:: PMC3198379

Abstract Article PDF–851K

Select item 294425012.

Regulation of the Na-Cl cotransporter NCC by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone

Volker Vallon

Kidney Int. Author manuscript; available in PMC 2010 Sep 23.

Published in final edited form as: Kidney Int. 2008 Dec; 74(11): 1373–1375. doi: 10.1038/ki.2008.477

PMCID:: PMC2944250

Abstract Article PDF–419K

Select item 360567513.

WNK1 Protein Kinase Regulates Embryonic Cardiovascular Development through the OSR1 Signaling Cascade

Jian Xie, Joonho Yoon, Sung-Sen Yang, Shih-Hua Lin, Chou-Long Huang

J Biol Chem. 2013 Mar 22; 288(12): 8566–8574. Published online 2013 Feb 5. doi: 10.1074/jbc.M113.451575

PMCID:: PMC3605675

Abstract Article PDF–2.0M

Select item 317257614.

A SPAK isoform switch modulates renal salt transport and blood pressure

James A. McCormick, Kerim Mutig, Joshua H. Nelson, Turgay Saritas, Ewout J. Hoorn, Chao-Ling Yang, Shaunessy Rogers, Joshua Curry, Eric Delpire, Sebastian Bachmann, David H. Ellison

Cell Metab. Author manuscript; available in PMC 2012 Sep 7.

Published in final edited form as: Cell Metab. 2011 Sep 7; 14(3): 352–364. doi: 10.1016/j.cmet.2011.07.009

PMCID:: PMC3172576

Abstract Article PDF–3.3M

Select item 268285015.

The Ste20 Kinases Ste20-related Proline-Alanine-rich Kinase and Oxidative-stress Response 1 Regulate NKCC1 Function in Sensory Neurons

Yang Geng, Ahmet Hoke, Eric Delpire

J Biol Chem. 2009 May 22; 284(21): 14020–14028. doi: 10.1074/jbc.M900142200

PMCID:: PMC2682850

Abstract Article PDF–597K

Select item 759126016.

Critical role of WNK1 in MYC-dependent early mouse thymocyte development

Robert Köchl, Lesley Vanes, Miriam Llorian Sopena, Probir Chakravarty, Harald Hartweger, Kathryn Fountain, Andrea White, Jennifer Cowan, Graham Anderson, Victor LJ Tybulewicz

eLife. 2020; 9: e56934. Published online 2020 Oct 14. doi: 10.7554/eLife.56934

PMCID:: PMC7591260

Abstract Article PDF–2.2M

Select item 987232817.

B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice

Darryl A. Hayward, Lesley Vanes, Stefanie Wissmann, Sujana Sivapatham, Harald Hartweger, Joshua Biggs O’May, Leonard L. de Boer, Richard Mitter, Robert Köchl, Jens V. Stein, Victor L.J. Tybulewicz

J Exp Med. 2023 Mar 6; 220(3): e20211827. Published online 2023 Jan 20. doi: 10.1084/jem.20211827

PMCID:: PMC9872328

Abstract Article PDF–6.8M

Select item 429428718.

Identification of the WNK-SPAK/OSR1 Signaling Pathway in Rodent and Human Lenses

Irene Vorontsova, Leo Lam, Eric Delpire, Julie Lim, Paul Donaldson

Invest Ophthalmol Vis Sci. 2015 Jan; 56(1): 310–321. Published online 2015 Jan 13. doi: 10.1167/iovs.14-15911

PMCID:: PMC4294287

Abstract Article PDF–2.0M

Select item 499487319.

WNK1 kinase balances T cell adhesion versus migration in vivo

Robert Köchl, Flavian Thelen, Lesley Vanes, Tiago F. Brazao, Kathryn Fountain, Jian Xie, Chou-Long Huang, Ruth Lyck, Jens V. Stein, Victor L. J. Tybulewicz

Nat Immunol. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Nat Immunol. 2016 Sep; 17(9): 1075–1083. Published online 2016 Jul 11. doi: 10.1038/ni.3495