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Select item 104391461.

One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression

Masato Sasaki, Kazuo Yamamoto, Takeshi Ueda, Hayato Irokawa, Kouki Takeda, Ryoya Sekine, Fumie Itoh, Yutaka Tanaka, Shusuke Kuge, Nobuyuki Shibata

Sci Rep. 2023; 13: 13486. Published online 2023 Aug 18. doi: 10.1038/s41598-023-38142-5

PMCID:: PMC10439146

Abstract Article PDF–3.9M

Select item 100281652.

Abnormal downregulation of 10‐formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway

Yi Qu, Ying He, Hanjin Ruan, Lizheng Qin, Zhengxue Han

Cancer Med. 2023 Mar; 12(5): 5781–5797. Published online 2022 Nov 6. doi: 10.1002/cam4.5327

PMCID:: PMC10028165

Abstract Article PDF–4.7M

Select item 62895163.

Modeling of interactions between functional domains of ALDH1L1

David A. Horita, Sergey A. Krupenko

Chem Biol Interact. Author manuscript; available in PMC 2018 Dec 11.

Published in final edited form as: Chem Biol Interact. 2017 Oct 1; 276: 23–30. Published online 2017 Apr 14. doi: 10.1016/j.cbi.2017.04.011

PMCID:: PMC6289516

Abstract Article PDF–2.9M

Select item 52265164.

Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion

Joon Hee Kang, Seon-Hyeong Lee, Jae-Seon Lee, Boas Nam, Tae Wha Seong, Jaekyoung Son, Hyonchol Jang, Kyeong Man Hong, Cheolju Lee, Soo-Youl Kim

Oncotarget. 2016 Aug 2; 7(31): 49397–49410. Published online 2016 Jun 30. doi: 10.18632/oncotarget.10354

PMCID:: PMC5226516

Abstract Article PDF–10M

Select item 33521555.

Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress

L. Alexis Hoeferlin, Natalia V. Oleinik, Natalia I. Krupenko, Sergey A. Krupenko

Genes Cancer. 2011 Sep; 2(9): 889–899. doi: 10.1177/1947601911432495

PMCID:: PMC3352155

Abstract Article PDF–664K

Select item 31983926.

Comprehensive Evaluation of One-Carbon Metabolism Pathway Gene Variants and Renal Cell Cancer Risk

Todd M. Gibson, Paul Brennan, Summer Han, Sara Karami, David Zaridze, Vladimir Janout, Helen Kollarova, Vladimir Bencko, Marie Navratilova, Neonila Szeszenia-Dabrowska, Dana Mates, Alena Slamova, Ruth M. Pfeiffer, Rachael Z. Stolzenberg-Solomon, Susan T. Mayne, Meredith Yeager, Stephen Chanock, Nat Rothman, Wong-Ho Chow, Philip S. Rosenberg, Paolo Boffetta, Lee E. Moore

PLoS One. 2011; 6(10): e26165. Published online 2011 Oct 19. doi: 10.1371/journal.pone.0026165

PMCID:: PMC3198392

Abstract Article PDF–111K

Select item 31231007.

Conserved Catalytic Residues of the ALDH1L1 Aldehyde Dehydrogenase Domain Control Binding and Discharging of the Coenzyme

Yaroslav Tsybovsky, Sergey A. Krupenko

J Biol Chem. 2011 Jul 1; 286(26): 23357–23367. Published online 2011 May 3. doi: 10.1074/jbc.M111.221069

PMCID:: PMC3123100

Abstract Article PDF–3.3M

Select item 31112448.

Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers

Natalia V. Oleinik, Natalia I. Krupenko, Sergey A. Krupenko

Genes Cancer. 2011 Feb; 2(2): 130–139. doi: 10.1177/1947601911405841

PMCID:: PMC3111244

Abstract Article PDF–702K

Select item 31036169.

PHYLOGENY AND EVOLUTION OF ALDEHYDE DEHYDROGENASE-HOMOLOGOUS FOLATE ENZYMES

Kyle C. Strickland, Roger S. Holmes, Natalia V. Oleinik, Natalia I. Krupenko, Sergey A. Krupenko

Chem Biol Interact. Author manuscript; available in PMC 2012 May 30.

Published in final edited form as: Chem Biol Interact. 2011 May 30; 191(1-3): 122–128. Published online 2011 Jan 6. doi: 10.1016/j.cbi.2010.12.025

PMCID:: PMC3103616

Abstract Article PDF–353K

Select item 266499010.

FDH: an Aldehyde Dehydrogenase Fusion Enzyme in Folate Metabolism

Sergey A. Krupenko

Chem Biol Interact. Author manuscript; available in PMC 2010 Mar 16.

Published in final edited form as: Chem Biol Interact. 2009 Mar 16; 178(1-3): 84–93. Published online 2008 Sep 19. doi: 10.1016/j.cbi.2008.09.007

PMCID:: PMC2664990

Abstract Article PDF–2.3M

Select item 934897511.

Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children

Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti

Am J Clin Nutr. 2022 Aug; 116(2): 500–510. Published online 2022 Apr 23. doi: 10.1093/ajcn/nqac091

PMCID:: PMC9348975

Abstract Article PDF–962K

Select item 554903012.

ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma

Guangzhi Zhu, Xiwen Liao, Chuangye Han, Xiaoguang Liu, Long Yu, Wei Qin, Sicong Lu, Hao Su, Zhiwei Chen, Zhengtao Liu, Yu Liang, Jianlu Huang, Tingdong Yu, Chengkun Yang, Ketuan Huang, Liming Shang, Xinping Ye, Lequn Li, Xue Qin, Kaiyin Xiao, Minhao Peng, Tao Peng

Oncol Rep. 2017 Sep; 38(3): 1451–1463. Published online 2017 Jul 14. doi: 10.3892/or.2017.5822

PMCID:: PMC5549030

Abstract Article PDF–1.2M

Select item 299209813.

ALDH1L1 Inhibits Cell Motility Via Dephosphorylation of Cofilin by PP1 and PP2A

Natalia V. Oleinik, Natalia I. Krupenko, Sergey A. Krupenko

Oncogene. Author manuscript; available in PMC 2011 May 25.

Published in final edited form as: Oncogene. 2010 Nov 25; 29(47): 6233–6244. Published online 2010 Aug 23. doi: 10.1038/onc.2010.356

PMCID:: PMC2992098

Abstract Article PDF–786K

Select item 273060214.

Gene Expression Profiling of NF1-Associated and Sporadic Pilocytic Astrocytoma Identifies Aldehyde Dehydrogenase 1 Family, Member L1 (ALDH1L1) as an Underexpressed Candidate Biomarker in Aggressive Subtypes

Fausto J. Rodriguez, Caterina Giannini, Yan W. Asmann, Mukesh K. Sharma, Arie Perry, Kathleen M. Tibbetts, Robert B. Jenkins, Bernd W. Scheithauer, Shrikant Anant, Sarah Jenkins, Charles G. Eberhart, Jann N. Sarkaria, David H. Gutmann

J Neuropathol Exp Neurol. Author manuscript; available in PMC 2009 Dec 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2008 Dec; 67(12): 1194–1204. doi: 10.1097/NEN.0b013e31818fbe1e

PMCID:: PMC2730602

Abstract Article PDF–5.5M

Select item 4522615.

Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice.

K M Champion, R J Cook, S L Tollaksen, C S Giometti

Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24): 11338–11342. doi: 10.1073/pnas.91.24.11338

PMCID:: PMC45226

Summary Page Browse PDF–1.4M

Select item 504190816.

Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer

Jia-Xin Shen, Jing Liu, Guan-Wu Li, Yi-Teng Huang, Hua-Tao Wu

Oncotarget. 2016 May 3; 7(18): 25340–25349. Published online 2016 Mar 23. doi: 10.18632/oncotarget.8294

PMCID:: PMC5041908

Abstract Article PDF–5.6M

Select item 280432017.

Acyl Carrier Protein-specific 4′-Phosphopantetheinyl Transferase Activates 10-Formyltetrahydrofolate Dehydrogenase

Kyle C. Strickland, L. Alexis Hoeferlin, Natalia V. Oleinik, Natalia I. Krupenko, Sergey A. Krupenko

J Biol Chem. 2010 Jan 15; 285(3): 1627–1633. Published online 2009 Nov 20. doi: 10.1074/jbc.M109.080556

PMCID:: PMC2804320

Abstract Article PDF–1.2M

Select item 412310518.

JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1

A Prakasam, S Ghose, N V Oleinik, J R Bethard, Y K Peterson, N I Krupenko, S A Krupenko

Cell Death Dis. 2014 Jul; 5(7): e1358. Published online 2014 Jul 31. doi: 10.1038/cddis.2014.316

PMCID:: PMC4123105

Abstract Article PDF–2.9M

Select item 290629919.

ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase

Natalia I. Krupenko, Marianne E. Dubard, Kyle C. Strickland, Kelly M. Moxley, Natalia V. Oleinik, Sergey A. Krupenko

J Biol Chem. 2010 Jul 23; 285(30): 23056–23063. Published online 2010 May 24. doi: 10.1074/jbc.M110.128843

PMCID:: PMC2906299

Abstract Article PDF–2.4M

Select item 415176420.

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma

Frances E. Lock, Rita Rebollo, Katharine Miceli-Royer, Liane Gagnier, Sabrina Kuah, Artem Babaian, Maialen Sistiaga-Poveda, C. Benjamin Lai, Oksana Nemirovsky, Isabel Serrano, Christian Steidl, Mohammad M. Karimi, Dixie L. Mager

Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): E3534–E3543. Published online 2014 Aug 11. doi: 10.1073/pnas.1405507111

Correction in:: Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33): E4630.

PMCID:: PMC4151764

Abstract Article PDF–2.0M

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