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Select item 87190381.

Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells

Zhe Liu, Xuanjia Dong, Zhijie Cao, Shaowei Qiu, Yihui Li, Mengjun Zhong, Zhenya Xue, Yingxi Xu, Haiyan Xing, Kejing Tang, Zheng Tian, Min Wang, Qing Rao, Jianxiang Wang

Exp Biol Med (Maywood) 2021 Aug; 246(15): 1750–1759. Published online 2021 May 25. doi: 10.1177/15353702211010130

PMCID:: PMC8719038

Abstract Article PDF–1.3M

Select item 82839432.

U2af1 is required for survival and function of hematopoietic stem/progenitor cells

Avik Dutta, Yue Yang, Bao T. Le, Yifan Zhang, Omar Abdel-Wahab, Chongzhi Zang, Golam Mohi

Leukemia. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Leukemia. 2021 Aug; 35(8): 2382–2398. Published online 2021 Jan 7. doi: 10.1038/s41375-020-01116-x

PMCID:: PMC8283943

Abstract Article PDF–2.7M

Select item 82693013.

Aberrant Alternative Splicing in U2af1/Tet2 Double Mutant Mice Contributes to Major Hematological Phenotypes

Cristina Martínez-Valiente, Cristian Garcia-Ruiz, Beatriz Rosón, Alessandro Liquori, Elisa González-Romero, Raúl Fernández-González, Isabel Gómez-Redondo, José Cervera, Alfonso Gutiérrez-Adán, Alejandra Sanjuan-Pla

Int J Mol Sci. 2021 Jul; 22(13): 6963. Published online 2021 Jun 28. doi: 10.3390/ijms22136963

PMCID:: PMC8269301

Abstract Article PDF–5.4M

Select item 43381064.

Dosage of the Abcg1-U2af1 Region Modifies Locomotor and Cognitive Deficits Observed in the Tc1 Mouse Model of Down Syndrome

Damien Marechal, Patricia Lopes Pereira, Arnaud Duchon, Yann Herault

PLoS One. 2015; 10(2): e0115302. Published online 2015 Feb 23. doi: 10.1371/journal.pone.0115302

PMCID:: PMC4338106

Abstract Article PDF–496K

Select item 27783715.

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

Patricia Lopes Pereira, Laetitia Magnol, Ignasi Sahún, Véronique Brault, Arnaud Duchon, Paola Prandini, Agnès Gruart, Jean-Charles Bizot, Bernadette Chadefaux-Vekemans, Samuel Deutsch, Fabrice Trovero, José María Delgado-García, Stylianos E. Antonarakis, Mara Dierssen, Yann Herault

Hum Mol Genet. 2009 Dec 15; 18(24): 4756–4769. Published online 2009 Sep 26. doi: 10.1093/hmg/ddp438

PMCID:: PMC2778371

Abstract Article PDF–527K

Select item 68211566.

mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control

Jae-Woong Chang, Hsin-Sung Yeh, Meeyeon Park, Luke Erber, Jiao Sun, Sze Cheng, Alexander M Bui, Naima Ahmed Fahmi, Ryan Nasti, Rui Kuang, Yue Chen, Wei Zhang, Jeongsik Yong

Nucleic Acids Res. 2019 Nov 4; 47(19): 10373–10387. Published online 2019 Sep 3. doi: 10.1093/nar/gkz761

PMCID:: PMC6821156

Abstract Article PDF–3.9M

Select item 62173977.

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

Dennis Liang Fei, Tao Zhen, Benjamin Durham, John Ferrarone, Tuo Zhang, Lisa Garrett, Akihide Yoshimi, Omar Abdel-Wahab, Robert K. Bradley, Paul Liu, Harold Varmus

Proc Natl Acad Sci U S A. 2018 Oct 30; 115(44): E10437–E10446. Published online 2018 Oct 15. doi: 10.1073/pnas.1812669115

PMCID:: PMC6217397

Abstract Article PDF–1.7M

Select item 44308548.

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

Cara Lunn Shirai, James N. Ley, Brian S. White, Sanghyun Kim, Justin Tibbitts, Jin Shao, Matthew Ndonwi, Brian Wadugu, Eric J. Duncavage, Theresa Okeyo-Owuor, Tuoen Liu, Malachi Griffith, Sean McGrath, Vincent Magrini, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Timothy A. Graubert, Matthew J. Walter

Cancer Cell. Author manuscript; available in PMC 2016 May 11.

Published in final edited form as: Cancer Cell. 2015 May 11; 27(5): 631–643. doi: 10.1016/j.ccell.2015.04.008

PMCID:: PMC4430854

Abstract Article PDF–1.6M

Select item 105391739.

Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis

Natalia J. Gurule, Kenneth C. Malcolm, Chelsea Harris, Jennifer R. Knapp, Brian P. O’Connor, Jazalle McClendon, William J. Janssen, Frank Fang Yao Lee, Caitlin Price, Jackson Osaghae-Nosa, Emily A. Wheeler, Christine M. McMahon, Eric M. Pietras, Daniel A. Pollyea, Scott Alper

Leukemia. 2023; 37(10): 2115–2124. Published online 2023 Aug 17. doi: 10.1038/s41375-023-02007-7

PMCID:: PMC10539173

Abstract Article PDF–2.8M

Select item 855356610.

U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice

Brian A. Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O. Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L. Shirai, Ajay Khanna, Dennis L. Fei, Christopher A. Miller, Timothy A. Graubert, Matthew J. Walter

J Clin Invest. 2021 Nov 1; 131(21): e141401. Published online 2021 Nov 1. doi: 10.1172/JCI141401

PMCID:: PMC8553566

Abstract Article PDF–5.4M

Select item 845421711.

Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice

Sanghyun P. Kim, Sridhar N. Srivatsan, Monique Chavez, Cara L. Shirai, Brian S. White, Tanzir Ahmed, Michael O. Alberti, Jin Shao, Ryan Nunley, Lynn S. White, Jeff Bednarski, John R. Pehrson, Matthew J. Walter

Cell Rep. Author manuscript; available in PMC 2021 Sep 21.

Published in final edited form as: Cell Rep. 2021 Aug 31; 36(9): 109626. doi: 10.1016/j.celrep.2021.109626

PMCID:: PMC8454217

Abstract Article PDF–1.7M

Select item 501211112.

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3’ End Formation

Sung Mi Park, Jianhong Ou, Lynn Chamberlain, Tessa M. Simone, Huan Yang, Ching-Man Virbasius, Abdullah M. Ali, Lihua J. Zhu, Siddhartha Mukherjee, Azra Raza, Michael R. Green

Mol Cell. Author manuscript; available in PMC 2017 May 19.

Published in final edited form as: Mol Cell. 2016 May 19; 62(4): 479–490. Published online 2016 May 12. doi: 10.1016/j.molcel.2016.04.011

PMCID:: PMC5012111

Abstract Article PDF–2.0M

Select item 13421813.

Characterization of U2AF⁶, a Splicing Factor Related to U2AF³⁵

Jeremiah Shepard, Martin Reick, Sara Olson, Brenton R. Graveley

Mol Cell Biol. 2002 Jan; 22(1): 221–230. doi: 10.1128/MCB.22.1.221-230.2002

PMCID:: PMC134218

Abstract Article PDF–573K

Select item 106961914.

Demian Cazalla, Kathryn Newton, Javier F. Cáceres

Mol Cell Biol. 2005 Apr; 25(8): 2969–2980. doi: 10.1128/MCB.25.8.2969-2980.2005

PMCID:: PMC1069619

Abstract Article PDF–823K

Select item 809881415.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

Shalini Menon, Dennis Goldfarb, Chris T. Ho, Erica W. Cloer, Nicholas P. Boyer, Christopher Hardie, Andrew J. Bock, Emma C. Johnson, Joel Anil, M. Ben Major, Stephanie L. Gupton

Mol Biol Cell. 2021 Feb 15; 32(4): 314–330. doi: 10.1091/mbc.E20-10-0622

PMCID:: PMC8098814

Abstract Article PDF–7.7M

Select item 874425716.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 119959117.

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain

Adrienne E McKee, Emmanuel Minet, Charlene Stern, Shervin Riahi, Charles D Stiles, Pamela A Silver

BMC Dev Biol. 2005; 5: 14. Published online 2005 Jul 20. doi: 10.1186/1471-213X-5-14

PMCID:: PMC1199591

Abstract Article PDF–2.0M

Select item 626277718.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 624418319.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 538122620.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

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