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Select item 110197521.

Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity

Inga Jarmoskaite, Jin Billy Li

RNA. 2024 May; 30(5): 500–511. doi: 10.1261/rna.079953.124

PMCID:: PMC11019752

Abstract Article PDF–1.5M

Select item 109623562.

Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

Maria Rivera, Haoran Zhang, Jessica Pham, Jane Isquith, Qingchen Jenny Zhou, Larisa Balaian, Roman Sasik, Sabina Enlund, Adam Mark, Wenxue Ma, Frida Holm, Kathleen M. Fisch, Dennis John Kuo, Catriona Jamieson, Qingfei Jiang

Cell Rep. Author manuscript; available in PMC 2024 Mar 25.

Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113704. Published online 2024 Jan 23. doi: 10.1016/j.celrep.2024.113704

PMCID:: PMC10962356

Abstract Article PDF–1.9M

Select item 108722543.

Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1

Agya Karki, Kristen B Campbell, Sukanya Mozumder, Andrew J. Fisher, Peter A. Beal

Biochemistry. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochemistry. 2024 Feb 6; 63(3): 282–293. Published online 2024 Jan 8. doi: 10.1021/acs.biochem.3c00405

PMCID:: PMC10872254

Abstract Article PDF–1.7M

Select item 103739654.

Clinical significance, tumor immune landscape and immunotherapy responses of ADAR in pan-cancer and its association with proliferation and metastasis of bladder cancer

Hao Yu, Kexin Bai, Yidong Cheng, Jiancheng Lv, Qiang Song, Haiwei Yang, Qiang Lu, Xiao Yang

Aging (Albany NY) 2023 Jul 15; 15(13): 6302–6330. Published online 2023 Jul 6. doi: 10.18632/aging.204853

PMCID:: PMC10373965

Abstract Article PDF–18M

Select item 103582045.

ADAR1 is a prognostic biomarker and is correlated with immune infiltration in lung adenocarcinoma

Wendi Yang, Kehong Chen, Qian Yu, Rongxin Liao, Hengqiu He, Yuan Peng, Zhenzhou Yang, Xiaoyue Zhang

Cancer Med. 2023 Jul; 12(13): 14820–14832. Published online 2023 May 10. doi: 10.1002/cam4.6044

PMCID:: PMC10358204

Abstract Article PDF–20M

Select item 102060706.

Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer

Najat Binothman, Majidah Aljadani, Bandar Alghanem, Mohammed Y. Refai, Mamoon Rashid, Abeer Al Tuwaijri, Nouf H. Alsubhi, Ghadeer I. Alrefaei, Muhammad Yasir Khan, Sultan N. Sonbul, Fadwa Aljoud, Sultan Alhayyani, Rwaa H. Abdulal, Magdah Ganash, Anwar M. Hashem

Sci Rep. 2023; 13: 8341. Published online 2023 May 23. doi: 10.1038/s41598-023-35517-6

PMCID:: PMC10206070

Abstract Article PDF–2.7M

Select item 100365267.

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer

Keiichiro Nakamura, Kunitoshi Shigeyasu, Kazuhiro Okamoto, Hirofumi Matsuoka, Hisashi Masuyama

Sci Rep. 2023; 13: 4720. Published online 2023 Mar 23. doi: 10.1038/s41598-023-30452-y

PMCID:: PMC10036526

Abstract Article PDF–9.4M

Select item 99742498.

A Comprehensive and Systematic Analysis Revealed the Role of ADAR1 in Pan-Cancer Prognosis and Immune Implications

Jianlin Zhu, Jianjian Zheng, Jinjun Zhang, Songyu Wang, Lu Wang, Yan Zhao

Dis Markers. 2023; 2023: 7620181. Published online 2023 Feb 21. doi: 10.1155/2023/7620181

PMCID:: PMC9974249

Abstract Article PDF–4.3M

Select item 99025159.

ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer

Nanako Hata, Kunitoshi Shigeyasu, Yuzo Umeda, Shuya Yano, Sho Takeda, Kazuhiro Yoshida, Tomokazu Fuji, Ryuichi Yoshida, Kazuya Yasui, Hibiki Umeda, Toshiaki Takahashi, Yoshitaka Kondo, Hiroyuki Kishimoto, Yoshiko Mori, Fuminori Teraishi, Hideki Yamamoto, Hiroyuki Michiue, Keiichiro Nakamura, Hiroshi Tazawa, Toshiyoshi Fujiwara

Sci Rep. 2023; 13: 2078. Published online 2023 Feb 6. doi: 10.1038/s41598-023-29397-z

PMCID:: PMC9902515

Abstract Article PDF–1.4M

Select item 974245910.

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, Alexandra Coomans de Brachène, Angela Castela, Maikel Colli, Piero Marchetti, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide

Front Endocrinol (Lausanne) 2022; 13: 1058345. Published online 2022 Nov 28. doi: 10.3389/fendo.2022.1058345

PMCID:: PMC9742459

Abstract Article PDF–5.9M

Select item 963893911.

ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site

Erin E Doherty, Agya Karki, Xander E Wilcox, Herra G Mendoza, Aashrita Manjunath, Victorio Jauregui Matos, Andrew J Fisher, Peter A Beal

Nucleic Acids Res. 2022 Oct 28; 50(19): 10857–10868. Published online 2022 Oct 16. doi: 10.1093/nar/gkac897

PMCID:: PMC9638939

Abstract Article PDF–2.8M

Select item 928331612.

ADAR1 and its implications in cancer development and treatment

Allison R. Baker, Frank J. Slack

Trends Genet. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Trends Genet. 2022 Aug; 38(8): 821–830. Published online 2022 Apr 19. doi: 10.1016/j.tig.2022.03.013

PMCID:: PMC9283316

Abstract Article PDF–433K

Select item 877446713.

Detection of A-to-I RNA Editing in SARS-COV-2

Ernesto Picardi, Luigi Mansi, Graziano Pesole

Genes (Basel) 2022 Jan; 13(1): 41. Published online 2021 Dec 23. doi: 10.3390/genes13010041

PMCID:: PMC8774467

Abstract Article PDF–9.5M

Select item 865183414.

The role of RNA editing enzyme ADAR1 in human disease

Brian Song, Yusuke Shiromoto, Moeko Minakuchi, Kazuko Nishikura

Wiley Interdiscip Rev RNA. Author manuscript; available in PMC 2022 Jan 15.

Published in final edited form as: Wiley Interdiscip Rev RNA. 2022 Jan; 13(1): e1665. Published online 2021 Jun 8. doi: 10.1002/wrna.1665

PMCID:: PMC8651834

Abstract Article PDF–1.3M

Select item 858418915.

Deciphering the Biological Significance of ADAR1–Z-RNA Interactions

Taisuke Nakahama, Yukio Kawahara

Int J Mol Sci. 2021 Nov; 22(21): 11435. Published online 2021 Oct 23. doi: 10.3390/ijms222111435

PMCID:: PMC8584189

Abstract Article PDF–2.1M

Select item 842838216.

Marburg and Ebola Virus mRNA 3′ Untranslated Regions Contain Negative Regulators of Translation That Are Modulated by ADAR1 Editing

Sudip Khadka, Caroline G. Williams, Joyce Sweeney-Gibbons, Christopher F. Basler

J Virol. 2021 Oct; 95(19): e00652-21. Prepublished online 2021 Aug 4. Published online 2021 Sep 9. doi: 10.1128/JVI.00652-21

PMCID:: PMC8428382

Abstract Article PDF–3.5M

Select item 786269517.

Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Parker J. Nichols, Shaun Bevers, Morkos Henen, Jeffrey S. Kieft, Quentin Vicens, Beat Vögeli

Nat Commun. 2021; 12: 793. Published online 2021 Feb 4. doi: 10.1038/s41467-021-21039-0

PMCID:: PMC7862695

Abstract Article PDF–9.4M

Select item 779695018.

Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer

Che-Pei Kung, Kyle A. Cottrell, Sua Ryu, Emily R. Bramel, Raleigh D. Kladney, Emily A. Bross, Eric C. Freeman, Thwisha Sabloak, Leonard Maggi, Jr., Jason D. Weber

Oncogene. Author manuscript; available in PMC 2021 Apr 27.

Published in final edited form as: Oncogene. 2021 Jan; 40(1): 189–202. Published online 2020 Oct 27. doi: 10.1038/s41388-020-01515-5