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Select item 110747911.

ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection

Clara Bredow, Fabien Thery, Eva Katrin Wirth, Sarah Ochs, Meike Kespohl, Gunnar Kleinau, Nicolas Kelm, Niclas Gimber, Jan Schmoranzer, Martin Voss, Karin Klingel, Joachim Spranger, Kostja Renko, Markus Ralser, Michael Mülleder, Arnd Heuser, Klaus-Peter Knobeloch, Patrick Scheerer, Jennifer Kirwan, Ulrike Brüning, Nikolaus Berndt, Francis Impens, Antje Beling

Cardiovasc Res. 2024 Apr; 120(6): 644–657. Published online 2024 Feb 3. doi: 10.1093/cvr/cvae026

PMCID:: PMC11074791

Abstract Article PDF–1.5M

Select item 102698062.

ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions

Martina Bécares, Manuel Albert, Céline Tárrega, Rocío Coloma, Michela Falqui, Emma K. Luhmann, Lilliana Radoshevich, Susana Guerra

Microbiol Spectr. 2023 May-Jun; 11(3): e04508-22. Published online 2023 Apr 10. doi: 10.1128/spectrum.04508-22

PMCID:: PMC10269806

Abstract Article PDF–2.2M

Select item 102041613.

ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma

Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao, Wenfeng Cao

J Transl Med. 2023; 21: 341. Published online 2023 May 22. doi: 10.1186/s12967-023-04135-1

PMCID:: PMC10204161

Abstract Article PDF–16M

Select item 101767484.

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1

Yaru Chen, Jiawei Zhou, Shang Wu, Lei Wang, Gaogui Chen, Dake Chen, Xianwen Peng, Yi-Liang Miao, Shuqi Mei, Fenge Li

Cell Biosci. 2023; 13: 84. Published online 2023 May 11. doi: 10.1186/s13578-023-01024-4

PMCID:: PMC10176748

Abstract Article PDF–3.3M

Select item 101330965.

ISGylation of NF-κBp65 by SCF^FBXL19 E3 ligase diminishes endothelial inflammation

Lian Li, Jiaxing Miao, Nargis Shaheen, Sarah J. Taleb, Jian Hu, Qinmao Ye, Jinshan He, Jiasheng Yan, Rama K. Mallampalli, Jing Zhao, Yutong Zhao

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 May; 43(5): 674–683. Published online 2023 Mar 30. doi: 10.1161/ATVBAHA.122.318894

PMCID:: PMC10133096

Abstract Article PDF–1.9M

Select item 96488406.

Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling

Huimin Liu, Chen Li, Wenfeng He, Jing Chen, Guoqing Yang, Lu Chen, Hongtao Chang

PLoS Pathog. 2022 Oct; 18(10): e1010921. Published online 2022 Oct 31. doi: 10.1371/journal.ppat.1010921

PMCID:: PMC9648840

Abstract Article PDF–3.5M

Select item 95028457.

Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity

Chen Li, Wen-Feng He, Long-Xi Li, Jing Chen, Guo-Qing Yang, Hong-Tao Chang, Hui-Min Liu

Viruses. 2022 Sep; 14(9): 1862. Published online 2022 Aug 24. doi: 10.3390/v14091862

PMCID:: PMC9502845

Abstract Article PDF–2.7M

Select item 71283118.

IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell–Dependent Route

Victoria Iglesias-Guimarais, Tomasz Ahrends, Evert de Vries, Klaus-Peter Knobeloch, Andriy Volkov, Jannie Borst

J Immunol. 2020 Apr 15; 204(8): 2110–2121. Published online 2020 Mar 13. doi: 10.4049/jimmunol.1901410

PMCID:: PMC7128311

Abstract Article PDF–1.7M

Select item 56597989.

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection

Sara Baldanta, Mercedes Fernández-Escobar, Rebeca Acín-Perez, Manuel Albert, Emilio Camafeita, Inmaculada Jorge, Jesús Vázquez, José Antonio Enríquez, Susana Guerra

PLoS Pathog. 2017 Oct; 13(10): e1006651. Published online 2017 Oct 27. doi: 10.1371/journal.ppat.1006651

PMCID:: PMC5659798

Abstract Article PDF–9.2M

Select item 546942510.

ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis

Chen Dong, Nan Gao, Bing X. Ross, Fu-Shin X. Yu

Invest Ophthalmol Vis Sci. 2017 Jul; 58(7): 2948–2958. doi: 10.1167/iovs.17-21476

PMCID:: PMC5469425

Abstract Article PDF–1.2M

Select item 456153211.

The ubiquitin-like protein, ISG15, is a novel tumor-associated antigen for cancer immunotherapy

Laurence M. Wood, Zhen-Kun Pan, Matthew M. Seavey, Geetha Muthukumaran, Yvonne Paterson

Cancer Immunol Immunother. 2012 May; 61(5): 689–700. Published online 2011 Nov 6. doi: 10.1007/s00262-011-1129-9

PMCID:: PMC4561532

Abstract Article PDF–467K

Select item 450444012.

Interferon-Stimulated Gene 15 Upregulation Precedes the Development of Blood–Brain Barrier Disruption and Cerebral Edema after Traumatic Brain Injury in Young Mice

Janet L. Rossi, Tracey Todd, Zachary Daniels, Nicolas G. Bazan, Ludmila Belayev

J Neurotrauma. 2015 Jul 15; 32(14): 1101–1108. doi: 10.1089/neu.2014.3611

PMCID:: PMC4504440

Abstract Article PDF–537K

Select item 430111513.

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in Mice

David J. Morales, Kristen Monte, Lulu Sun, Jessica J. Struckhoff, Eugene Agapov, Michael J. Holtzman, Thaddeus S. Stappenbeck, Deborah J. Lenschow

J Virol. 2015 Jan 1; 89(1): 337–349. Prepublished online 2014 Oct 15. Published online 2014 Dec 16. doi: 10.1128/JVI.02110-14

PMCID:: PMC4301115

Abstract Article PDF–5.4M

Select item 413628714.

ISG15 Functions as an Interferon-Mediated Antiviral Effector Early in the Murine Norovirus Life Cycle

Marisela R. Rodriguez, Kristen Monte, Larissa B. Thackray, Deborah J. Lenschow

J Virol. 2014 Aug; 88(16): 9277–9286. doi: 10.1128/JVI.01422-14

PMCID:: PMC4136287

Abstract Article PDF–1.2M

Select item 379685115.

ISG15 Regulates Peritoneal Macrophages Functionality against Viral Infection

Emilio Yángüez, Alicia García-Culebras, Aldo Frau, Catalina Llompart, Klaus-Peter Knobeloch, Sylvia Gutierrez-Erlandsson, Adolfo García-Sastre, Mariano Esteban, Amelia Nieto, Susana Guerra

PLoS Pathog. 2013 Oct; 9(10): e1003632. Published online 2013 Oct 10. doi: 10.1371/journal.ppat.1003632