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Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
QC Inhibition Testing from Article 10.1021/bi051142e: "Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase."
Assay data:1 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay validation screen against the NCATS LOPAC Collection
Assay data:10 Active, 7 Activity ≤ 1 µM, 1248 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltransferases
Assay data:968 Active, 24930 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Assay data:237 Active, 1947 Activity ≤ 1 µM, 141380 Tested
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression
Assay data:177 Active, 2 Activity ≤ 1 nM, 481 Activity ≤ 1 µM, 146379 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Primary qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2)
Assay data:249 Active, 449 Activity ≤ 1 µM, 100803 Tested
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
Assay data:41 Active, 124 Activity ≤ 1 µM, 15613 Tested
Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
Assay data:265 Active, 171 Activity ≤ 1 µM, 15637 Tested
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
Assay data:160 Active, 22 Activity ≤ 1 µM, 15634 Tested
Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
Assay data:115 Active, 91 Activity ≤ 1 µM, 15634 Tested
Primary qHTS assay for inhibitors of the protease papain
Assay data:54 Active, 27 Activity ≤ 1 µM, 1272 Tested
Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay
Assay data:41 Active, 8 Activity ≤ 1 nM, 357 Activity ≤ 1 µM, 11292 Tested
Validation qHTS for Identification of Calcium Integrin Binding protein 1 (CIB1) Competitor
Assay data:10 Active, 7 Activity ≤ 1 µM, 1277 Tested
Primary qHTS for inhibitors of La Crosse Virus (LACV) - induced cell death in SH-SY5Y cells
Assay data:30 Active, 282 Activity ≤ 1 µM, 3830 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Corrector activity at CFTR F508 deletion mutant in primary human BE cells assessed as induction of autophagy by measuring decrease in p62 level at 250 uM measured after 24 hrs in presence of DHA by immunoblotting
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Corrector activity at CFTR F508 deletion mutant in primary human BE cells assessed as induction of autophagy by measuring increase in LC3-2 to LC3-1 ratio at 250 uM measured after 24 hrs in presence of DHA by immunoblotting
Corrector activity at CFTR F508 deletion mutant in primary human BE cells assessed as induction of autophagy by measuring increase in beclin-1 level at 250 uM in presence of DHA measured after 24 hrs by immunoblotting
Corrector activity at CFTR F508 deletion mutant in primary human BE cells assessed as induction of autophagy by measuring decrease in p62 level at 250 uM measured after 24 hrs by immunoblotting
Assay data:2 Tested
Corrector activity at CFTR F508 deletion mutant in primary human BE cells assessed as induction of autophagy by measuring increase in LC3-2 to LC3-1 ratio at 250 uM measured after 24 hrs by immunoblotting
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