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Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Isothermal Titration Calorimetry (ITC) from Article 10.1074/jbc.M113.510743: "A L-lysine transporter of high stereoselectivity of the amino acid-polyamine-organocation (APC) superfamily: production, functional characterization, and structure modeling."
Assay data:2 Tested
SummaryPubMed Citation
NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS
Assay data:25 Active, 678 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
Assay data:41 Active, 124 Activity ≤ 1 µM, 15613 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
Assay data:265 Active, 171 Activity ≤ 1 µM, 15637 Tested
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
Assay data:160 Active, 22 Activity ≤ 1 µM, 15634 Tested
Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
Assay data:115 Active, 91 Activity ≤ 1 µM, 15634 Tested
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:368 Active, 78 Activity ≤ 1 µM, 5114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Assay data:158 Active, 29 Activity ≤ 1 µM, 5114 Tested
Primary qHTS for Vero E6 cytotoxicity: counterscreen for inhibitors of SARS-S pseudo-typed particle cell entry
Assay data:20 Active, 14 Activity ≤ 1 µM, 2678 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Primary qHTS for inhibitors of MERS-S pseudo-typed particle cell entry
Assay data:88 Active, 17 Activity ≤ 1 µM, 2678 Tested
Primary qHTS for Huh7 cytotoxicity: counterscreen for inhibitors of MERS-S pseudotyped particle cell entry
Assay data:25 Active, 8 Activity ≤ 1 µM, 2678 Tested
Primary qHTS for inhibitors of SARS-S pseudo-typed particle cell entry
Assay data:73 Active, 72 Activity ≤ 1 µM, 2678 Tested
Binding affinity to HCV 5'-Alexa488-labeled IRES domain 3 loop RNA at 20 degC after overnight incubation by fluorescence assay
Assay data:2 Active, 16 Tested
SummaryCompounds, ActivePubMed Citation
P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen
Assay data:1430 Active, 11 Activity ≤ 1 nM, 385 Activity ≤ 1 µM, 10968 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen
Assay data:1153 Active, 10968 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Human pregnane X receptor (PXR) activation by small molecules, qHTS assay
Assay data:229 Active, 16 Activity ≤ 1 µM, 2454 Tested
CYP3A4 induction through human pregnane X receptor (PXR) by small molecules, qHTS assay
Assay data:172 Active, 50 Activity ≤ 1 µM, 2454 Tested
Rat pregnane X receptor (rPXR) activation by small molecules, qHTS assay
Assay data:107 Active, 27 Activity ≤ 1 µM, 2454 Tested
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