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Downregulation of Myb gene expression in human MV4-11 cells at 0.1 uM incubated for 4 hrs by qRT-PCR analysis
Assay data:2 Tested
SummaryPubMed Citation
Downregulation of Myc gene expression in human MV4-11 cells at 0.1 uM incubated for 4 hrs by qRT-PCR analysis
Downregulation of Bcl-2 gene expression in human MV4-11 cells at 0.1 uM incubated for 4 hrs by qRT-PCR analysis
Downregulation of MCL-1 gene expression in human MV4-11 cells at 0.1 uM incubated for 4 hrs by qRT-PCR analysis
Downregulation of MEISI gene expression in human MV4-11 cells at 0.1 uM incubated for 4 hrs by qRT-PCR analysis
Downregulation of HOXA9 gene expression in human MV4-11 cells at 0.1 uM incubated for 4 hrs by qRT-PCR analysis
Antiproliferative activity against human MV4-11 cells assessed as reduction of cell viability at 10 uM incubated for 3 days in presence of cytokines followed by culturing in fresh medium containing cytokines and measured after 7 days by AnnexinV-FITC staining based flow cytometry
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of FLT3 in FLT3-independent human NOMO-1 cells assessed as decrease in MYC transcript levels at 0.2 to 125 nM incubated for 4 hrs by qRT-PCR analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antiproliferative activity against FLT3-independent human K562 cells assessed as cell growth inhibition upto 10 uM by resorufin dye based fluorescence analysis
Assay data:1 Tested
Antiproliferative activity against FLT3-independent human NOMO-1 cells assessed as cell growth inhibition upto 10 uM by resorufin dye based fluorescence analysis
Antiproliferative activity against FLT3-independent human CEM cells assessed as cell growth inhibition upto 10 uM by resorufin dye based fluorescence analysis
Primary qHTS assay for Inhibitors of ovarian cancer metastasis using an organotypic tumor microenvironment (TME) model.
Assay data:60 Active, 47 Activity ≤ 1 µM, 45897 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS28BM_JCRB cell viability assay
Assay data:615 Active, 4 Activity ≤ 1 nM, 321 Activity ≤ 1 µM, 1911 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: PCM6_Riken cell viability assay
Assay data:827 Active, 17 Activity ≤ 1 nM, 293 Activity ≤ 1 µM, 1912 Tested
IC50 Kinase Assays from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:50 Active, 8 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:8 Active, 7 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
HotSpot Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:30 Active, 6 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY7_PLB cell viability assay
Assay data:828 Active, 37 Activity ≤ 1 nM, 590 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: L363_DSMZ cell viability assay
Assay data:540 Active, 30 Activity ≤ 1 nM, 593 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1S_ATCC cell viability assay
Assay data:1053 Active, 13 Activity ≤ 1 nM, 437 Activity ≤ 1 µM, 1911 Tested
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