BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 15

Select item 16523541.

Inhibition of recombinant human Lp-PLA2 (47 to 429 residues) expressed in Escherichia coli RosettaTM2 (DE3) pLysS

Source:: ChEMBL

Assay data:9 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 10 Tested

AID:: 1652354

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 14721552.

Inhibition of human recombinant GST-tagged Lp-PLA2 (47 to 429 residues) expressed in Escherichia coli Rosetta(DE3) pLysS using 2-thio-PAF as substrate preincubated for 30 min followed by substrate addition measured every minute for 10 mins by DNTB reagent based assay

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:29 Active, 1 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 30 Tested

AID:: 1472155

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13733713.

Inhibition of human Lp-PLA2

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1373371

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13733704.

Inhibition of Lp-PLA2 in human plasma LDL fractions using 2-thio platelet-activating factor as substrate by TMB dye based spectrophotometry

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:2 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1373370

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13313505.

Inhibition of human recombinant LpPLA2

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1331350

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13225146.

Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrate

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:17 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 23 Tested

AID:: 1322514

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13225137.

Inhibition of recombinant human Lp-PLA2 incubated for 20 mins by Thio-PAF assay

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:10 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 11 Tested

AID:: 1322513

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13225128.

Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate addition

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:16 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 17 Tested

AID:: 1322512

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13088119.

Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assay

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:10 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 12 Tested

AID:: 1308811

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 129361810.

Inhibition of recombinant human Lp-PLA2 using 2-thio-PAF as substrate measured for 10 mins by plate reader analysis

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:21 Active, 1 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested

AID:: 1293618

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 125658911.

Inhibition of recombinant human Lp-PLA2 using 2-thio-PAF substrate after 10 mins

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:14 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested

AID:: 1256589

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 125658212.

Inhibition of Lp-PLA2 (unknown origin)

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1256582

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 74682313.

Inhibition of recombinant human Lp-PLA2 using [3H]PAF as substrate at 10 nM incubated for 5 mins prior to substrate addition measured after 10 mins by liquid scintillation counting analysis

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:15 Active, 13 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 27 Tested

AID:: 746823

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10382414.

Inhibitory activity against recombinant human Lp-PLA2 by mechanistic studies

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 103824

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10381415.

Inhibitory activity against recombinant human Lp-PLA2

Source:: ChEMBL

Protein Target:: Platelet-activating factor acetylhydrolase

Assay data:23 Active, 14 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested

AID:: 103814

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (15)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (15)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (15)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (15)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (15)
BioAssays extracted from the literature

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BioAssays, activity concentration at/below 1 nM for PubChem Compo... (15)
BioAssays, activity concentration at/below 1 nM for PubChem Compound (Select 9939609)
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