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Agonist activity at alpha4beta2 nAChR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to Sprague-Dawley rat brain nAChR incubated for 90 min by scatchard analysis
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Assay data:7 Active, 6 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
BK Channel Variant Modulator Selectivity Assay
Assay data:286 Active, 904 Activity ≤ 1 nM, 951 Activity ≤ 1 µM, 951 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of [3H]cytisine from human alpha4beta2 nAChR overexpressed in human SHEP cells after 75 mins by liquid scintillation spectrometric analysis
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Agonist activity at alpha4beta 2 nAChR
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]epibatidine from alpha4beta2* nAChR in Sprague-Dawley rat brain P2 membrane after 90 mins by liquid scintillation counting
Assay data:10 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 37 Tested
Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membrane
Assay data:11 Active, 4 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain minus cerebellum membrane
Assay data:24 Active, 13 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 42 Tested
Displacement of [3H]NMCI from nicotinic acetylcholine receptor
Displacement of [3H]cytisine from neuronal nicotinic acetylcholine receptor in rat brain membrane
Assay data:57 Active, 30 Activity ≤ 1 nM, 57 Activity ≤ 1 µM, 57 Tested
Displacement of [3H]cytisine from alpha-4-beta-2 in rat cerebral cortical membrane
Assay data:50 Active, 21 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 51 Tested
Inhibition of [3H]-nicotine binding to nicotinic acetylcholine receptor alpha4-beta2 in rat cortex
Inhibition of [3H]nicotine binding to nicotinic acetylcholine receptor alpha4-beta2 of rat cortex
Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of [3H]MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane
Tested for neuronal nicotinic acetylcholine receptor (nAChR) binding in a whole rat brain preparation using [3H]cystine as the radioligand.
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Binding affinity values obtained by measuring the displacement of radioligand [3H](-)-cytisine from a preparation of whole rat brain
Binding affinity towards alpha4-beta2 measured by using the inhibition of [3H]NIC binding to rat striatal membrane
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 16 Tested
Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
Assay data:11 Active, 5 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
In vitro binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]cytisine in rat brain
Assay data:11 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 16 Tested
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