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Inhibition of ACK1 (unknown origin)
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ACK1 D163E mutant in mouse BaF3 cells
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
Assay data:27 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 29 Tested
Inhibition of SRC (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of BCR-Abl (unknown origin)
Inhibition of human SRC by western blot assay
Binding affinity to Abl (unknown origin) assessed as inhibition constant
Binding affinity to Src (unknown origin) assessed as inhibition constant
Inhibition of ABL1 (unknown origin)
Growth inhibition of human K562 cells measured after 48 hrs by alamarblue assay
Assay data:28 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 34 Tested
Inhibition of LCK (unknown origin)
Binding affinity to Fyn (unknown origin) assessed as dissociation constant
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of BCR-ABL phosphorylation in human K562 cells
Inhibition of CSF1R (unknown origin) by enzymatic assay
Cytotoxicity against human KU812 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Assay data:10 Active, 6 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against mouse BAF3 cells expressing native BCR-ABL assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Assay data:9 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
FRET-Based Z'-Lyte Assay from Article 10.1111/cbdd.12863: "Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors."
Assay data:26 Active, 25 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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