BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 13

Select item 19482201.

Antiproliferative activity against human REC1 cells assessed as reduction in cell viability incubated for 6 days by CellTiter-Glo luminescent cell viability assay

Source:: ChEMBL

Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1948220

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19482122.

Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSSARQ-NH2 as substrate preincubated for 1 hrs followed by substrate addition in presence of ATP at Km concentration and measured after 1 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:38 Active, 8 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested

AID:: 1948212

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19131053.

Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a BMX

Source:: ChEMBL

Protein Target:: Cytoplasmic tyrosine-protein kinase BMX

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913105

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131034.

Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a BTK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913103

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18801355.

Inhibition of BTK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1880135

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18759186.

Inhibition of BTK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1875918

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18532047.

Inhibition of BTK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1853204

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17954888.

Kinase Assay from US Patent US9556188: "Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators"

Source:: BindingDB

Assay data:205 Active, 39 Activity ≤ 1 nM, 199 Activity ≤ 1 µM, 214 Tested

AID:: 1795488

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 16153689.

Inhibition of human BMX using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by filter binding method

Source:: ChEMBL

Protein Target:: Cytoplasmic tyrosine-protein kinase BMX

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1615368

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 161536310.

Inhibition of human BTK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by filter binding method

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1615363

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 161536211.

Antiproliferative activity against human OCI-LY10 cells after 6 days by Celltiter-glo luminescent cell viability assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1615362

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 161535912.

Antiproliferative activity against human Rec1 cells after 6 days by Celltiter-glo luminescent cell viability assay

Source:: ChEMBL

Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 7 Tested

AID:: 1615359

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 161534413.

Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells preincubated for 1 hr followed by Biotin-AVLESEEELYSSARQ-NH2 substrate addition in presence of ATP and measured after 1 hr by TR-FRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:35 Active, 14 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested

AID:: 1615344

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (13)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (13)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (13)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (13)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (11)
BioAssays extracted from the literature
Other (2)
BioAssays deposited by other experimentalists

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