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Cytotoxicity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by Cell titer-blue assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of FLT3 D835Y mutant (unknown origin) phosphorylation in mouse BaF3 cells
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FLT3 D835H mutant (unknown origin) phosphorylation in mouse BaF3 cells
Inhibition of wild type FLT3 (unknown origin)
Assay data:7 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
IC50 Kinase Assays from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:50 Active, 8 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:8 Active, 7 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Binding affinity to non-auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expression
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression system
Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression system
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of FLT3 D835H mutant (unknown origin)
Inhibition of FLT3 D835Y mutant (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
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