BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 16

Select item 19385531.

Binding affinity to human CRF1 receptor assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1938553

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12974102.

Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate after 2 hrs by gamma counting analysis

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:28 Active, 2 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested

AID:: 1297410

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6091823.

Antagonist activity at human CRF-1 receptor

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested

AID:: 609182

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 4213564.

Displacement of [125I]ovine-CRF from CRF1 receptor in rat frontal cortex by rapid filtration technique

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:40 Active, 9 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested

AID:: 421356

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3543485.

Displacement of [125I]Tyr0-ovine CRF from CRF1 receptor in rat cortical membrane by gamma counting

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:46 Active, 2 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 46 Tested

AID:: 354348

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3468946.

Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:22 Active, 19 Activity ≤ 1 µM, 22 Tested

AID:: 346894

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3456937.

Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells by SPA

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:35 Active, 27 Activity ≤ 1 µM, 44 Tested

AID:: 345693

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3089798.

Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membrane

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested

AID:: 308979

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2431819.

Displacement of [125I]o-CRF from recombinant human CRF receptors expressed in Chinese Hamster Ovary (CHO) cell membranes

Source:: ChEMBL

Assay data:15 Active, 13 Activity ≤ 1 µM, 15 Tested

AID:: 243181

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 22002610.

Compound was tested for the binding affinity to human corticotropin releasing factor receptor

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 220026

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 22002211.

Inhibition of corticotropin releasing factor receptor mediated increase in adenylate cyclase activity was evaluated

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 220022

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5383212.

Displacement of [125I]-tyrosine-ovine-CRF from human Corticotropin releasing factor receptor 1

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:14 Active, 3 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested

AID:: 53832

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5381013.

Compound was tested for the binding affinity to human corticotropin releasing factor receptor

Source:: ChEMBL

Protein Target:: Corticotropin-releasing factor receptor 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 53810

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2852014.

oral pharmacokinetic parameter, Maximum concentration was reported in rats

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 28520

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 2851915.

oral pharmacokinetic parameter, Maximum concentration was reported in dogs

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 28519

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 2809816.

Cmax(nM)value was determined in rats after po dose of 5 mg/kg

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 28098

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

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BioActivity

Active Compounds (16)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (16)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (16)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (16)
BioAssays extracted from the literature

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BioAssays, activity concentration at/below 1 uM for PubChem Compo... (16)
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