BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19190801.

Inhibition of ALK Tyrosine Kinase Activity from US Patent US11517561: "Macrocycle and composition comprising thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1919080

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138142.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK3

Source:: ChEMBL

Protein Target:: NT-3 growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913814

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138133.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913813

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138124.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK1

Source:: ChEMBL

Protein Target:: High affinity nerve growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913812

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138115.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a FRK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase FRK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913811

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138106.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a JAK2

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913810

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138097.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a FES

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fes/Fps

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913809

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138088.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a FER

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fer

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913808

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138079.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a PTK2B

Source:: ChEMBL

Protein Target:: Protein-tyrosine kinase 2-beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913807

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380610.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a PTK2

Source:: ChEMBL

Protein Target:: Focal adhesion kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913806

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380511.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913805

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380412.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913804

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380313.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a LTK

Source:: ChEMBL

Protein Target:: Leukocyte tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913803

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380214.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a TNK2

Source:: ChEMBL

Protein Target:: Activated CDC42 kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913802

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191314215.

Affinity Biochemical interaction (Microfluidic mobility shift assay) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913142

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191314116.

Affinity Biochemical interaction (Microfluidic mobility shift assay) EUB0000690a ALK

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913141

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191289117.

Affinity On-target Cellular interaction (Sandwich ELISA (cell-based ROS1-fusion assay)) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912891

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191289018.

Affinity On-target Cellular interaction (ELISA (ALK phosphoryaltion in 3T3-EML4-ALK engineered cell lines)) EUB0000690a ALK

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912890

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191272519.

Affinity Phenotypic Cellular interaction (Free plasma tumor growth inhibition assay) EUB0000690a ROS1

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase ROS

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912725

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180409720.

Assay for Inhibition of ALK Tyrosine Kinase Activity from US Patent US10543199: "Macrocycle and composition comprising thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 1

Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1804097

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (81)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (32)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (81)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (79)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (60)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (20)
BioAssays deposited by other experimentalists

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