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Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS20_JCRB cell viability assay
Assay data:588 Active, 31 Activity ≤ 1 nM, 546 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: JIM1_ECACC cell viability assay
Assay data:457 Active, 27 Activity ≤ 1 nM, 619 Activity ≤ 1 µM, 1912 Tested
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:1774 Active, 1 Activity ≤ 1 nM, 362 Activity ≤ 1 µM, 5242 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
High-throughput drug toxicity screening in the BPDCN cell line Gen2.2
Assay data:29 Activity ≤ 1 nM, 425 Activity ≤ 1 µM, 1910 Tested
SummaryCompounds, activity ≤ 1 µM
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation
Assay data:57 Activity ≤ 1 nM, 344 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2)
Assay data:53 Activity ≤ 1 nM, 332 Activity ≤ 1 µM, 2023 Tested
Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells
Assay data:13 Active, 11 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assay
Assay data:35 Active, 34 Activity ≤ 1 µM, 36 Tested
Inhibition of CaSR in bovine parathyroid cells assessed as increase in PTH level
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human CaSR expressed in HEK293 cells
Inhibition of beta2 adrenergic receptor
Assay data:3 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of human ERG
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of CYP2D6
Assay data:5 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of DAT
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of NET
Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of SERT
Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in human HEK293 4.0-7 cells by liquid scintillation counting
Assay data:6 Active, 4 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assay
Assay data:5 Active, 4 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation
Assay data:8 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
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