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Human Orexin 1 Receptor Radioligand Binding Studies from US Patent US11667644: "Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators"
Assay data:235 Active, 111 Activity ≤ 1 µM, 353 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Human Orexin 2 Receptor Radioligand Binding Studies from US Patent US11667644: "Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators"
Assay data:353 Active, 290 Activity ≤ 1 µM, 378 Tested
Human Orexin 1 Receptor Radioligand Binding Studies from US Patent USRE48841: "Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators"
Assay data:234 Active, 111 Activity ≤ 1 µM, 352 Tested
Human Orexin 2 Receptor Radioligand Binding Studies from US Patent USRE48841: "Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators"
Assay data:352 Active, 289 Activity ≤ 1 µM, 377 Tested
Human Orexin 1 Receptor Radioligand Binding Studies from US Patent US11059828: "Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators"
Assay data:234 Active, 111 Activity ≤ 1 µM, 351 Tested
Human Orexin 2 Receptor Radioligand Binding Studies from US Patent US11059828: "Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators"
Assay data:352 Active, 289 Activity ≤ 1 µM, 376 Tested
Biological Assay from US Patent US8653263: "Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators"
Assay data:353 Active, 293 Activity ≤ 1 µM, 377 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Receptor Radioligand Binding Assay from US Patent US9586962: "Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators"
Assay data:290 Active, 127 Activity ≤ 1 µM, 424 Tested
Assay data:422 Active, 351 Activity ≤ 1 µM, 449 Tested
Displacement of [3H]EMPA from human orexin-2 receptor expressed in HEK293 cells after 60 mins by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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