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Sterol-Binding Assay from Article 10.1074/jbc.M114.571216: "Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Induction of human HMGCR-dCat-ELuc degradation expressed in HEK293 cells assessed as reduction in luciferase activity after 4 hrs by luciferase reporter assay
Assay data:9 Active, 2 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human integrin alphavbeta3 by surface plasmon resonance method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activity at 6His-tagged human RORgamma LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of biotinylated SRC1 co-activator peptide recruitment by alphascreen assay
Agonist activity at 6xHis tagged human RORgammat LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as biotinylated SRC1-2 peptide coactivator recruitment by AlphaScreen assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested
Drug repurposing screens with cells derived from glioblastoma tumor samples
Assay data:1237 Active, 3 Activity ≤ 1 nM, 360 Activity ≤ 1 µM, 3733 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysis
Assay data:46 Active, 45 Activity ≤ 1 µM, 46 Tested
Agonist activity at human His6-tagged ROR gamma ligand binding domain (residues 262 to 507) expressed in Escherichia coli BL21 (DE3) cells assessed as increase in recruitment of coactivator peptide by AlphaScreen biochemical assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line
Assay data:2493 Active, 2 Activity ≤ 1 nM, 413 Activity ≤ 1 µM, 10486 Tested
Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 20 hrs by luciferase reporter gene assay
Assay data:17 Active, 3 Activity ≤ 1 µM, 27 Tested
Agonist activity at hedgehog receptor
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Tested for its inhibitory activity against HMG-CoA reductase transcription in HepG2 cells
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
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