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Inhibition of ROCK1 (unknown origin)
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ROCK2 (unknown origin)
Assay data:21 Active, 5 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition Assay from US Patent US9221808: "Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use"
Assay data:67 Active, 45 Activity ≤ 1 µM, 88 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:1774 Active, 1 Activity ≤ 1 nM, 362 Activity ≤ 1 µM, 5242 Tested
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
Assay data:1106 Active, 14 Activity ≤ 1 nM, 6478 Activity ≤ 1 µM, 7578 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assay
Assay data:43 Active, 1 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 49 Tested
Inhibition of N-terminal GST-tagged ROCK1 (1 to 535) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assay
Assay data:42 Active, 31 Activity ≤ 1 µM, 49 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
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