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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Agonist activity at human PGR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:55 Active, 39 Activity ≤ 1 µM, 930 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human NR3C1 in an in vitro cell free assay measured by filtration, radioactivity method
Assay data:83 Active, 2 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 1095 Tested
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of LPS induced NO production
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of recombinant human sPLA2-V
Assay data:7 Active, 2 Activity ≤ 1 µM, 7 Tested
Agonist activity at glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as transactivation of receptor incubated for 18 hrs by firefly luciferase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Modulation of glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as transrepression by measuring inhibition of PMA-induced AP-1 signalling incubated for 18 hrs by dual-luciferase reporter based assay
Assay data:48 Active, 10 Activity ≤ 1 µM, 64 Tested
Modulation of glucocorticoid receptor (unknown origin) transfected in human HeLa cells assessed as transrepression by measuring inhibition of TNF-alpha induced NF-kappaB signalling incubated for 18 hrs by dual-luciferase reporter based assay
Assay data:49 Active, 38 Activity ≤ 1 µM, 64 Tested
Binding affinity to glucocorticoid receptor (unknown origin) by Lanthascreen TR-FRET competition binding assay
Assay data:24 Active, 5 Activity ≤ 1 µM, 65 Tested
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Glucocorticoid Receptor Competitor Assay from US Patent US11554172: "Phosphonate linkers and their use to facilitate cellular retention of compounds"
Assay data:22 Active, 9 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY5_PLB cell viability assay
Assay data:980 Active, 10 Activity ≤ 1 nM, 428 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: L363_DSMZ cell viability assay
Assay data:540 Active, 30 Activity ≤ 1 nM, 593 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: LP1_DSMZ cell viability assay
Assay data:486 Active, 24 Activity ≤ 1 nM, 280 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1S_ATCC cell viability assay
Assay data:1053 Active, 13 Activity ≤ 1 nM, 437 Activity ≤ 1 µM, 1911 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS21BM_JCRB cell viability assay
Assay data:650 Active, 358 Activity ≤ 1 nM, 751 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS20_JCRB cell viability assay
Assay data:588 Active, 31 Activity ≤ 1 nM, 546 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS12BM_JCRB cell viability assay
Assay data:870 Active, 12 Activity ≤ 1 nM, 424 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Karpas25_ECACC cell viability assay
Assay data:975 Active, 20 Activity ≤ 1 nM, 350 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KHM11_PLB cell viability assay
Assay data:572 Active, 29 Activity ≤ 1 nM, 524 Activity ≤ 1 µM, 1912 Tested
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