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Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting
Assay data:123 Active, 40 Activity ≤ 1 µM, 1197 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Pseudomonas aeruginosa FabI
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Mycobacterium tuberculosis InhA
Inhibition of Plasmodium falciparum NF54 HDAC using extract measured after 60 mins by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of Mycobacterial tuberculosis ATCC 25618 FabI assessed as measuring NADH consumption rate
Inhibition of wild type Escherichia coli FabI assessed as inhibition of bacterial growth
Assay data:5 Active, 4 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate
Assay data:6 Active, 5 Activity ≤ 1 µM, 9 Tested
Inhibition Kinetics Assay from Article 10.1021/acs.biochem.6b01048: "Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase."
Assay data:23 Active, 2 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 23 Tested
TgENR Inhibition Assay from Article 10.1021/bi400945y: "Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay."
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Thermal Shift Assay from Article 10.1021/bi400413c: "Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme-Product Complex."
Assay data:20 Active, 16 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Fabl Assay from Article 10.1111/cbdd.12118: "Design, Synthesis, Structural Characterization by IR, (1) H, (13) C, (15) N, 2D-NMR, X-Ray Diffraction and Evaluation of a New Class of Phenylaminoacetic Acid Benzylidene Hydrazines as pfENR Inhibitors."
Assay data:3 Active, 1 Activity ≤ 1 µM, 21 Tested
Enzyme Inhibition Assay from Article 10.1021/cb800306y: "Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity."
Assay data:12 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
PfENR Enzymatic Inhibition Assay from Article 10.1074/jbc.m701813200: "X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy."
Assay data:24 Active, 23 Activity ≤ 1 µM, 28 Tested
Measurement of Inhibition Constants from Article 10.1021/cb0500042: "High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enoyl-CoA Reductase Inhibition Assay from Article 10.1021/cb0500042: "High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis."
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Enzyme Inhibition Assay from Article 10.1016/s0960-894x(01)00405-x: "Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents."
Assay data:32 Active, 18 Activity ≤ 1 µM, 35 Tested
Enzyme Inhibition Assay from Article 10.1016/s0960-894x(01)00404-8: "1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)."
Assay data:10 Active, 3 Activity ≤ 1 µM, 22 Tested
Enzyme Inhibition Assay from Article 10.1021/jm0204035: "Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK."
Assay data:11 Active, 9 Activity ≤ 1 µM, 11 Tested
Enzyme Inhibition Assay from Article 10.1021/jm020050+: "Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)."
Assay data:9 Active, 1 Activity ≤ 1 µM, 15 Tested
Inhibition of Mycobacterium tuberculosis InhA
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