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Inhibition of human recombinant IDO1 expressed in Escherichia coli
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: L363_DSMZ cell viability assay
Assay data:540 Active, 30 Activity ≤ 1 nM, 593 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Inhibition of N-terminal 3xFlag-His6-tagged SARS-CoV-2 papain-like protease nsp3 (1564 to 1878 residues) expressed in baculovirus infected Sf9 insect cells using Pro3 as substrate by fluorescence based assay
Assay data:8 Active, 5 Activity ≤ 1 µM, 8 Tested
Inhibition of IDO1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of IDO1 in IFNgamma-induced human HeLa cells incubated for 5 hrs by Ehrlich's reagent based assay
Inhibition of purified human recombinant IDO1 expressed in Escherichia coli assessed as reduction in kynurenine production incubated up to 90 mins using L-Trp substrate by Ehrlich's reagent based spectrophotometry
Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis
Assay data:28 Active, 10 Activity ≤ 1 µM, 58 Tested
Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis
Assay data:16 Active, 7 Activity ≤ 1 µM, 58 Tested
Inhibition of IDO1 in human IFN-gamma induced HeLa cells assessed as reduction in L-kynurenine formation incubated for 5 hrs
Inhibition of recombinant human IDO1 expressed in Escherichia coli assessed as reduction in formation of kynurenine using L-tryptophan as substrate measured up to 90 mins by spectrophotometric method
Antihyperproliferative activity against human HaCaT cells after 48 hrs by MTT assay
Assay data:26 Active, 11 Activity ≤ 1 µM, 54 Tested
Inhibition of human intestinal CES2 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for 5 mins
Assay data:10 Active, 9 Activity ≤ 1 µM, 22 Tested
Cytotoxicity against human MDA-MB-435 cells overexpressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay
Assay data:23 Active, 8 Activity ≤ 1 µM, 26 Tested
Cytotoxicity against human SF295 cells overexpressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay
Assay data:21 Active, 8 Activity ≤ 1 µM, 25 Tested
Cytotoxicity against human HCT116 cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay
Assay data:24 Active, 7 Activity ≤ 1 µM, 27 Tested
Antiproliferative activity against apoptosis sensitive human MCF7 cells after 72 hrs by MTT assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 21 Tested
Antiproliferative activity against apoptosis sensitive human PC3 cells after 72 hrs by MTT assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 21 Tested
Antiproliferative activity against apoptosis sensitive mouse B16F10 cells after 72 hrs by MTT assay
Assay data:12 Active, 5 Activity ≤ 1 µM, 21 Tested
Antiproliferative activity against apoptosis sensitive human Hs683 cells after 72 hrs by MTT assay
Assay data:6 Active, 1 Activity ≤ 1 µM, 21 Tested
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