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Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in HEK293 cells by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human NOP receptor expressed in CHO cells assessed as dynamic mass redistribution by DMR assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated for 15 mins followed by forskolin addition measured for 90 mins by luciferase reporter gene assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 7 Tested
Displacement of [3H]nociceptin from human recombinant Nociceptin receptor expressed in HEK293 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human recombinant NOP receptor expressed in CHO cells co-expressing C-terminally modifed Gaqi5 protein by Fluo-4AM dye based calcium mobilization assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor low affinity binding site expressed in African green monkey COS7 cells after 90 mins by topcount analysis
Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins by topcount analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysis
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to human ORL1 receptor expressed in African green monkey COS7 cells assessed per mg protein after 90 mins by Scatchard plot analysis
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at human nociceptin opioid receptor transfected in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Displacement of [3H]N/OFQ from human nociceptin opioid receptor transfected in CHO cell membranes
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 13 Tested
Antagonist activity at human NOP receptor expressed in CHO cells assessed as inhibition of nociceptin-induced [35S]-GTPgammaS binding after 2 hrs
Assay data:17 Active, 15 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation counting
Assay data:17 Active, 17 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Binding affinity to ORL1 receptor (unknown origin) by radioligand displacement assay
Binding affinity to human NOP receptor by radioligand displacement assay
Displacement of [3H]nociceptin from rat Galpha-fused ORL1 receptor expressed in african green monkey COS7 cells
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting
Assay data:12 Active, 12 Activity ≤ 1 µM, 13 Tested
Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting
Partial agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Partial agonist activity at human KOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
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