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Antagonist activity at P2Y12 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of P2Y12 (unknown origin)
Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
Ca++ flux assay from US Patent US10220040: "Compounds, compositions and methods useful for cholesterol mobilization"
Assay data:1 Active, 9 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Mouse GPR17 (Class A Orphans)
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human P2Y12 receptor (P2Y receptors)
Assay data:23 Active, 23 Tested
Human P2Y13 receptor (P2Y receptors)
Assay data:15 Active, 15 Tested
Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
Antagonist activity at human platelet P2Y12 receptor assessed as inhibition of ADP-mediated decrease in intra-platelet phosphorylated VASP by FLUO-4 staining based flow cytometric analysis
Assay data:14 Active, 7 Activity ≤ 1 µM, 16 Tested
Antagonist activity at P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced aggregation preincubated for 5 mins followed by ADP addition by turbidimetric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Platelet P2T receptor antagonist activity in human platelet assay
Assay data:10 Active, 4 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
The compound was evaluated for antagonist activity against platelet P2Y purinoceptor 12 (P2Y12)
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