BioAssays, Active for PubChem Compound (Select 92045023) - PubChem BioAssay - NCBI

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Items: 17

Select item 18949431.

Anticonvulsant activity in Kunming mouse plasma assessed as plasma EC50 level by rotarod test

Source:: ChEMBL

Assay data:1 Active, 2 Tested

AID:: 1894943

Summary Compounds, Active PubMed Citation

Select item 18949422.

Anticonvulsant activity in Kunming mouse brain assessed as brain EC50 level by rotarod test

Source:: ChEMBL

Assay data:1 Active, 2 Tested

AID:: 1894942

Summary Compounds, Active PubMed Citation

Select item 18949393.

Anticonvulsant activity in MES induced Kunming mouse model of seizure assessed as EC50 in plasma

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1894939

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18949384.

Anticonvulsant activity in MES induced Kunming mouse model of seizure assessed as EC50 in brain

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1894938

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18949375.

Drug concentration in Kunming mouse plasma at 5 mg/kg

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894937

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18949366.

Drug concentration in Kunming mouse brain at 5 mg/kg

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894936

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18949237.

Agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily KQT member 2; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1894923

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18949228.

Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp method

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily KQT member 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1894922

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18948939.

Time dependent inhibition of human liver microsome CYP2B6 preincubated for 0.5 hrs in presence of NADPH followed by substrate addition by LC-MS/MS method

Source:: ChEMBL

Protein Target:: Cytochrome P450 2B6

Assay data:1 Active, 1 Tested

AID:: 1894893

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 189489110.

Time dependent inhibition of human liver microsome CYP1A2 preincubated for 0.5 hrs in presence of NADPH followed by substrate addition by LC-MS/MS method

Source:: ChEMBL

Protein Target:: Cytochrome P450 1A2

Assay data:1 Active, 1 Tested

AID:: 1894891

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 189485511.

Cmax in Sprague-Dawley rat blood at 6 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894855

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 189485412.

Cmax in Sprague-Dawley rat brain at 6 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1894854

Summary Compounds, Active PubMed Citation

Select item 189485313.

Cmax in Sprague-Dawley rat at 20 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894853

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 189485214.

Cmax in Sprague-Dawley rat at 6 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894852

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 189485115.

Cmax in Sprague-Dawley rat at 2 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894851

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 189483516.

Cmax in Kunming mouse brain at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894835

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 189483417.

Cmax in Kunming mouse plasma at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS method

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894834

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

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BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (12)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (17)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (17)
BioAssays extracted from the literature

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