BioAssays, Active for PubChem Compound (Select 71731823) - PubChem BioAssay - NCBI

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Select item 19635961.

Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: cytochrome P450 3A7 [Homo sapiens]

Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested

AID:: 1963596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 19618692.

Compound was evaluated for inhibition of human ACHE in an vitro cell free assay measured by absorbance method

Source:: ChEMBL

Protein Target:: Acetylcholinesterase

Assay data:10 Active, 5 Activity ≤ 1 µM, 73 Tested

AID:: 1961869

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618013.

Agonist activity at human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 1 group I member 2

Assay data:41 Active, 11 Activity ≤ 1 µM, 580 Tested

AID:: 1961801

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19617714.

Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:58 Active, 20 Activity ≤ 1 µM, 876 Tested

AID:: 1961771

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19617445.

Compound was evaluated for inhibition of human EGFR in an in vitro cell free assay measured by Caliper microfluidic capillary electrophoresis, time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:11 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 86 Tested

AID:: 1961744

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19616846.

Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Adenosine receptor A3

Assay data:82 Active, 4 Activity ≤ 1 µM, 1215 Tested

AID:: 1961684

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19190807.

Inhibition of ALK Tyrosine Kinase Activity from US Patent US11517561: "Macrocycle and composition comprising thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1919080

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138148.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK3

Source:: ChEMBL

Protein Target:: NT-3 growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913814

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138139.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913813

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191381210.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK1

Source:: ChEMBL

Protein Target:: High affinity nerve growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913812

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191381111.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a FRK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase FRK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913811

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191381012.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a JAK2

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913810

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380913.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a FES

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fes/Fps

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913809

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380814.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a FER

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fer

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913808

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380715.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a PTK2B

Source:: ChEMBL

Protein Target:: Protein-tyrosine kinase 2-beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913807

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380616.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a PTK2

Source:: ChEMBL

Protein Target:: Focal adhesion kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913806

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380517.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913805

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380418.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913804

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380319.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a LTK

Source:: ChEMBL

Protein Target:: Leukocyte tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913803

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191380220.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a TNK2

Source:: ChEMBL

Protein Target:: Activated CDC42 kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913802

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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Target

Proteins (8)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (107)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (31)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (85)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (92)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (2)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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Literature Extraction (77)
BioAssays extracted from the literature
Other (30)
BioAssays deposited by other experimentalists

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