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Sterol-Binding Assay from Article 10.1074/jbc.M114.571216: "Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cell-Free Ligand Sensing Assay (LiSA)-LXRalpha-SRC1 Assay from Article 10.1021/jm0004749: "Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha."
Assay data:14 Active, 11 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of human HMGCR-dCat-ELuc degradation expressed in HEK293 cells assessed as reduction in luciferase activity after 4 hrs by luciferase reporter assay
Assay data:9 Active, 2 Activity ≤ 1 µM, 13 Tested
Binding affinity to human integrin alphavbeta3 by surface plasmon resonance method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activity at 6His-tagged human RORgamma LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of biotinylated SRC1 co-activator peptide recruitment by alphascreen assay
Inhibition of SREBP (unknown origin) expressed in HEK293 cells assessed as reduction in LDLr promotor activity after 24 hrs by luciferase reporter assay
Assay data:5 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of OSBP localization in golgi apparatus of human HeLa cells assessed as increase in colocalization of 58K golgi protein at 0.5 uM incubated for 30 mins by immunofluorescence imaging method
Assay data:2 Active, 2 Tested
Agonist activity at 6xHis tagged human RORgammat LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as biotinylated SRC1-2 peptide coactivator recruitment by AlphaScreen assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested
Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells at 4 uM incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control
Drug repurposing screens with cells derived from glioblastoma tumor samples
Assay data:1237 Active, 3 Activity ≤ 1 nM, 360 Activity ≤ 1 µM, 3733 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Human GPR183 (Class A Orphans)
Assay data:8 Active, 8 Tested
Human RAR-related orphan receptor-gamma (1F. Retinoic acid-related orphans)
Assay data:5 Active, 5 Tested
Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy
Assay data:31 Active, 10 Activity ≤ 1 µM, 33 Tested
Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysis
Assay data:46 Active, 45 Activity ≤ 1 µM, 46 Tested
Agonist activity at human His6-tagged ROR gamma ligand binding domain (residues 262 to 507) expressed in Escherichia coli BL21 (DE3) cells assessed as increase in recruitment of coactivator peptide by AlphaScreen biochemical assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane after 24 hrs by fluorescence microscopic analysis
Assay data:20 Active, 2 Activity ≤ 1 µM, 27 Tested
Binding affinity to NPC1 (unknown origin)
Assay data:4 Active, 4 Tested
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line
Assay data:2501 Active, 1 Activity ≤ 1 nM, 348 Activity ≤ 1 µM, 10486 Tested
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line
Assay data:2493 Active, 2 Activity ≤ 1 nM, 413 Activity ≤ 1 µM, 10486 Tested
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