BioAssays, Active for PubChem Compound (Select 6099) - PubChem BioAssay - NCBI

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Select item 20316931.

Antiplasmodial activity against Plasmodium vivax assessed as parasitic growth inhibition

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 2031693

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 20316472.

Antiplasmodial activity against Plasmodium falciparum FCR-3 assessed as plasmodial growth inhibition

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 2031647

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19857363.

Antiplasmodial activity against immature stage gametocytes Plasmodium falciparum NF54 incubated for 48 hrs by luciferase activity assay

Source:: ChEMBL

Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested

AID:: 1985736

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19635974.

NCATS Human Liver Microsomal (HLM) Stability Profiling

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:542 Active, 900 Tested

AID:: 1963597

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor

Select item 19635965.

Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: cytochrome P450 3A7 [Homo sapiens]

Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested

AID:: 1963596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 19635846.

p53 small molecule agonists, cell-based qHTS assay: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested

AID:: 1963584

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635827.

p53 small molecule agonists, cell-based qHTS assay

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested

AID:: 1963582

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635798.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS cell viability counter screen

Source:: Tox21

Assay data:300 Active, 138 Activity ≤ 1 µM, 9667 Tested

AID:: 1963579

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19620169.

Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.

Source:: ChEMBL

Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested

AID:: 1962016

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 193652810.

Antiplasmodial activity against early stage (I to III) Plasmodium falciparum incubated for 48 hrs by bioluminescence assay

Source:: ChEMBL

Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1936528

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 193217811.

Anticancer activity against human HepG2 cells

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1932178

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 193217712.

Binding affinity to calf thymus DNA sequence

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1932177

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 193217613.

Binding affinity to human MYC G4 DNA sequence

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1932176

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 192992814.

Photo-oxygenation of human Amyloid beta (1 to 42) assessed as oxygen adduct formation at 1 uM measured after photoirradiation for 30 mins using LED by MALDI-TOF-MS analysis

Source:: ChEMBL

Protein Target:: Amyloid-beta precursor protein

Assay data:1 Active, 1 Tested

AID:: 1929928

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192992715.

Photo-oxygenation of human recombinant Myostatin expressed in Escherichia coli cells assessed as oxygen adduct formation at 1 uM measured after photoirradiation for 30 mins using LED by MALDI-TOF-MS analysis

Source:: ChEMBL

Protein Target:: Growth/differentiation factor 8

Assay data:1 Active, 1 Tested

AID:: 1929927

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 191997016.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1038 Active, 9667 Tested

AID:: 1919970

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 191996917.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested

AID:: 1919969

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 191996818.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: qHTS cell viability counter screen in human keratinocytes

Source:: Tox21

Assay data:683 Active, 47 Activity ≤ 1 µM, 9667 Tested

AID:: 1919968

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 189951919.

Antiproliferative activity against mouse B16-F10 cells assessed as cell viability in light irradiation and measured for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:1 Active, 3 Tested

AID:: 1899519

Summary Compounds, Active PubMed Citation

Select item 189951820.

Antiproliferative activity against mouse B16-F10 cells assessed as cell viability in dark incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:1 Active, 3 Tested

AID:: 1899518

Summary Compounds, Active PubMed Citation

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Target

Proteins (167)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (444)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (62)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (200)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (13)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (275)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (111)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (207)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (78)
BioAssays extracted from the literature
NIH MLP (192)
BioAssays deposited by the NIH Molecular Libraries Program
Other (161)
BioAssays deposited by other experimentalists

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