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Agonist activity at human PGR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:55 Active, 39 Activity ≤ 1 µM, 930 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human NR3C1 in an in vitro cell free assay measured by filtration, radioactivity method
Assay data:83 Active, 2 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 1095 Tested
Binding affinity towards rat Ar in an in vitro cell free assay measured by fluorescence polarization method
Assay data:45 Active, 19 Activity ≤ 1 µM, 667 Tested
Binding affinity to human Androgen receptor
Assay data:22 Active, 8 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
Inhibition of CYP3A4T in human liver microsomes incubated for 15 to 40 mins in presence of NADPH
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Modulation of Androgen receptor (unknown origin)
Assay data:20 Active, 8 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 21 Tested
Inhibition of CYP3A4T (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
HDAC Activity Assay from Article 10.1021/cb400542w: "Selectively targeting prostate cancer with antiandrogen equipped histone deacetylase inhibitors."
Assay data:16 Active, 7 Activity ≤ 1 µM, 16 Tested
Androgen Receptor Assay from US Patent US9682960: "Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety"
Assay data:117 Active, 127 Activity ≤ 1 µM, 127 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Anti late-onset hypogonadism activity in cyclophosphamide-induced Sprague-Dawley rat model of partial androgen deficiency assessed as inhibition of Leydig cells apoptosis at 10 mg/kg, sc administered for every 3 days up to 4 weeks by DAPI staining based TUNEL assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Anti late-onset hypogonadism activity in cyclophosphamide-induced Sprague-Dawley rat model of partial androgen deficiency assessed as increase in serum total testosterone level at 10 mg/kg, sc administered for every 3 days up to 4 weeks and measured every 2 weeks by ELISA
Anti late-onset hypogonadism activity in cyclophosphamide-induced Sprague-Dawley rat model of partial androgen deficiency assessed as increase in free testosterone level at 10 mg/kg, sc administered for every 3 days up to 4 weeks and measured every 2 weeks by ELISA
Androgenic activity at human androgen receptor expressed in African green monkey CV-1 cells assessed as increase in interaction between VP16-fused AR-NTD and GAL4-fused AR-LBD after 17 hrs by luciferase reporter gene assay
Assay data:8 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 26 Tested
Progesterone receptor (PR) small molecule agonists, qHTS assay: Summary
Assay data:193 Active, 7 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1
Assay data:13449 Active, 399619 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1
Assay data:5540 Active, 399561 Tested
Human pregnane X receptor (PXR) small molecule agonists, qHTS assay
Assay data:2218 Active, 1 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 9667 Tested
Mean steady-state pharmacokinetic parammeters for Testosterone evaluated on day 30 following multiple topical administration of Testosterone gel to adult male subjetcs with testosterone levels <= 300ng/dL.
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Rat Androgen receptor (3C. 3-Ketosteroid receptors)
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the estrogen related receptor (ERR) signaling pathway from Tox21 library: Summary
Assay data:807 Active, 131 Activity ≤ 1 µM, 9667 Tested
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