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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Antiviral activity against HIV infected in human C8166 cells
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against Enterovirus D68 infected in human RD cells assessed as inhibition of viral replication measured after 48 hrs by qRT-PCR analysis
Antiviral activity against Chikungunya virus
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against human KBM5 cells assessed as reduction in cell viability by MTT assay
Antiproliferative activity against human HCT-116 cells harboring KRAS G13D mutant assessed as cell growth inhibition measured after 96 hrs by MTT assay
Assay data:3 Active, 3 Tested
Inhibition of cisplatin-induced ICAM1 dependent HUVEC cells adhesion to human U-937 cells at 10 to 30 uM preincubated with HUVEC cells for 4.5 hrs in presence of cisplatin followed by U-937 cell suspension addition and measured after 1 hr by BCECF fluorescent probe based assay
Improvement in cisplatin-induced endothelial monolayer integrity in HUVEC cells assessed as reduction in transmembrane movement of albumin at 30 uM preincubated with compound followed by cisplatin stimulation and measured after 2 hrs
Improvement in cisplatin-induced endothelial monolayer integrity in HUVEC cells assessed as increase in transendothelial electric resistance at 30 uM preincubated with compound followed by cisplatin stimulation and measured after 45 mins
Inhibition of cisplatin-induced store operated Ca2+ release in HUVEC cells at 30 uM preincubated with compound followed by cisplatin stimulation by Fura-2 AM staining based calcium influx assay
Inhibition of cisplatin-induced TRPC1 phosphorylation in [32P] orthophosphate labeled HUVEC cells at 30 uM incubated for 15 mins in presence of cisplatin by Western blot analysis
Inhibition of cisplatin-induced PKCalpha translocation in HUVEC cells assessed as reduction in membrane PKCalpha activity at 30 uM incubated for 15 mins in presence of cisplatin by Western blot analysis
Inhibition of cisplatin-induced PKCalpha translocation in HUVEC cells assessed as increase in PKCalpha accumulation in cytosol at 30 uM incubated for 15 mins in presence of cisplatin by Western blot analysis
Downregulation of cisplatin-induced ICAM1 protein expression in HUVEC cells at 100 uM incubated for 1 hr by Western blot analysis
Downregulation of cisplatin-induced ICAM1 protein expression in HUVEC cells at 30 uM incubated for 1 hr by Western blot analysis
Upregulation of cytosolic p65 level in cisplatin-treated HUVEC cells at 30 uM incubated for 1 hr by Western blot analysis
Inhibition of cisplatin-induced phosphorylation of p65 subunit at Ser536 residue in HUVEC cells at 30 uM incubated for 1 hr by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of cisplatin-induced phosphorylation of IkappaBalpha at Ser32/36 residue in HUVEC cells at 30 uM incubated for 1 hr by Western blot analysis
Inhibition of cisplatin-induced NF-kappaB activation in HUVEC cell nuclear extract assessed as reduction in NF-kappaB-DNA binding activity at 30 uM incubated for 1 hr by electrophoretic mobility shift assay
Activation of AKT in cisplatin-treated HUVEC cells assessed as increase in AKT phosphorylation at 30 uM measured after 5 to 240 mins by Western blot analysis
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