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Inhibition of FYN (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LCK (unknown origin)
Binding affinity to chicken 6-His tagged c-Src expressed in Escherichia coli Bl21 (DE3) assessed as dissociation constant
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
ADP-Glo Kinase Assay from US Patent US10688093: "Methods, compositions, and uses of novel Fyn kinase inhibitors"
Assay data:592 Active, 193 Activity ≤ 1 µM, 647 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
luminescent kinase assay from US Patent US10544104: "Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases"
Assay data:129 Active, 6 Activity ≤ 1 nM, 112 Activity ≤ 1 µM, 141 Tested
In Vitor Src Tyrosine Kinase Activity Assay from Article 10.3109/14756366.2012.715288: "Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors."
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested
c-Src Kinase Inhibitory Activity Assay from Article 10.1016/j.bioorg.2014.02.001: "Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives."
Assay data:2 Active, 2 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9765037: "Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases"
Assay data:38 Active, 19 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of p38 alpha (unknown origin) using Ser/Thr 15 as substrate incubated for 1 hr in presence of ATP by Z'-Lyte assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 12 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Z'-LYTE: MAPK14 (p38 alpha) Direct, Direct Format, kinase activity assay, coupled enzyme activity measurement method, detected via fluorescence resonance energy transfer
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Z'-LYTE: MAPK11 (p38 beta), Direct Format, kinase activity assay, coupled enzyme activity measurement method, detected via fluorescence resonance energy transfer
Z'-LYTE: EPHB3, Direct Format, kinase activity assay, coupled enzyme activity measurement method, detected via fluorescence resonance energy transfer
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling
Assay data:1740 Active, 2530 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
NCATS Rat Liver Microsome Stability Profiling
Assay data:754 Active, 2531 Tested
Inhibition of FYN (unknown origin) by cell culture based assay
Growth inhibition of human A549 cells
Assay data:22 Active, 17 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of Src (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1
Assay data:13449 Active, 399619 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
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