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Drug uptake in INFgamma-stimulated mouse BV-2 cells assessed as increase in fluorescence at 10 uM pretreated with INFgamma and carboxyl-PTIO for 3 hrs followed by compound addition and measured after 3 hrs
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Drug uptake in LPS-stimulated mouse BV-2 cells assessed as increase in fluorescence at 10 uM pretreated with LPS and carboxyl-PTIO for 3 hrs followed by compound addition and measured after 3 hrs
Drug uptake in mouse HT-22 cells cocultured with BV-2 cells assessed as increase in fluorescence at 10 uM after 12 hrs
Drug uptake in L-arginine stimulated mouse BV-2 cells assessed as increase in fluorescence at 10 uM pretreated with L-arginine and L-NAA for 16 hrs followed by compound addition and measured after 3 hrs
Drug uptake in INFgamma-stimulated mouse BV-2 cells assessed as increase in fluorescence at 10 uM pretreated with INFgamma and L-NAA for 16 hrs followed by compound addition and measured after 3 hrs
Drug uptake in LPS-stimulated mouse BV-2 cells assessed as increase in fluorescence at 10 uM pretreated with LPS and L-NAA for 16 hrs followed by compound addition and measured after 3 hrs
Drug uptake in mouse BV-2 cells assessed as increase in fluorescence at 10 uM after 3 hrs
Drug uptake in L-arginine stimulated mouse BV-2 cells assessed as increase in fluorescence at 10 uM pretreated with L-arginine and carboxyl-PTIO for 3 hrs followed by compound addition and measured after 3 hrs
Enzyme Inhibition Assay from Article 10.1021/jm049011j: "Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases."
Assay data:36 Active, 30 Activity ≤ 1 µM, 60 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assay
Assay data:21 Active, 13 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Competitive inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Tested
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectroscopy
Assay data:6 Active, 1 Activity ≤ 1 µM, 7 Tested
Competitive inhibition of human brain mitochondria MAO-A using kynuramine as substrate by Lineweaver-Burk analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibitor identification of human QSOX1 enzyme: high-throughput screening using HyperBlu(TM) assay
Assay data:979 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Human TRPA1 (Transient Receptor Potential channels)
Assay data:37 Active, 37 Tested
qHTS assay to identify small molecule agonists of the estrogen receptor beta (ER-beta) signaling pathway: Summary
Assay data:149 Active, 1 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway in the presence of an antagonist: Summary
Assay data:219 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the hypoxia (HIF-1) signaling pathway - cell viability counter screen
Assay data:617 Active, 94 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS assay to identify small molecule inhibitors of firefly luciferase
Assay data:866 Active, 28 Activity ≤ 1 µM, 9667 Tested
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