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Antiglaucoma activity in ocular hypersensitive monkey assessed as reduction in intraocular pressure
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to EP2 (unknown origin) assessed as inhibition constant
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]prostaglandin E2 from recombinant human full length EP4 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scintillation counting
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins
Assay data:32 Active, 36 Activity ≤ 1 µM, 36 Tested
Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Reduction of intraocular pressure in ocular normotensive cynomolgus monkey at 0.3 to 1% administered topically to the eyes once daily at around 5 pm from day 1 to day 14 and measured at 10 pm at day 8 and 15 post dose
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
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