BioAssays, Active for PubChem Compound (Select 25206346) - PubChem BioAssay - NCBI

Warning: The NCBI web site requires JavaScript to function. more...

Links from PubChem Compound

Items: 19

Select item 9776081.

Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB

Source:: Shanghai Institute of Organic Chemistry

Protein Targets:: Chain 1, Chymotrypsinogen A; ...
Total:: 3277

Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested

AID:: 977608

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 7153472.

Inhibition of recombinant BRAF V600E mutant using GSTP1-MEK1 and [gamma-32P]ATP as substrate after 30 mins by scintillation counting

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 715347

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153463.

Inhibition of VEGFR2

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 715346

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153454.

Inhibition of BRAF V600E mutant in human HT-29 cells assessed as reduction of MRK phosphorylation

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:7 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 715345

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153425.

Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 days

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715342

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153416.

Inhibition of wild type human BRAF (445 to 726) expressed in Sf9 insect cells

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715341

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153407.

Inhibition of c-RAF

Source:: ChEMBL

Protein Target:: RAF proto-oncogene serine/threonine-protein kinase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715340

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153398.

Inhibition of FGFR3

Source:: ChEMBL

Protein Target:: Fibroblast growth factor receptor 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715339

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153389.

Inhibition of PDGFRbeta

Source:: ChEMBL

Protein Target:: Platelet-derived growth factor receptor beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715338

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533710.

Inhibition of PDGFRalpha

Source:: ChEMBL

Protein Target:: Platelet-derived growth factor receptor alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715337

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533511.

Inhibition of HER2

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Tested

AID:: 715335

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 71533312.

Inhibition of TIE2

Source:: ChEMBL

Protein Target:: Angiopoietin-1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715333

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533213.

Inhibition of c-Kit

Source:: ChEMBL

Protein Target:: Mast/stem cell growth factor receptor Kit

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715332

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533114.

Inhibition of Src

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715331

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71532915.

Inhibition of IKKbeta

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Tested

AID:: 715329

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 71532316.

Inhibition of CDK1

Source:: ChEMBL

Protein Target:: Cyclin-dependent kinase 1

Assay data:1 Active, 1 Tested

AID:: 715323

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 71532117.

Inhibition of aurora B

Source:: ChEMBL

Protein Target:: Aurora kinase B

Assay data:1 Active, 1 Tested

AID:: 715321

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 71531918.

Inhibition of p38alpha

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 14

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715319

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71531819.

Inhibition of MEK1

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715318

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Supplemental Content

Filters: Manage Filters

Refine your results

• What's this?

Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (19)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (15)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (18)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (19)
BioAssays extracted from the literature

Actions on your results

View or Download BioAssay in PubChem

Find related data

Recent activity

Clear Turn Off Turn On

BioAssays, Active for PubChem Compound (Select 25206346) (19)
PubChem BioAssay

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Chemicals & Bioassays > PubChem BioAssay