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Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy
Assay data:117 Active, 53 Activity ≤ 1 µM, 881 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of human KCNH2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
Assay data:353 Active, 116 Activity ≤ 1 µM, 1804 Tested
Binding affinity towards human HTR1A in an in vitro assay with cellular components measured by scintillation counting
Assay data:141 Active, 68 Activity ≤ 1 µM, 927 Tested
Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:58 Active, 20 Activity ≤ 1 µM, 876 Tested
Binding affinity towards human ADRB2 in an in vitro assay with cellular components measured by radioactivity method
Assay data:58 Active, 21 Activity ≤ 1 µM, 952 Tested
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
Assay data:66 Active, 1 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 1195 Tested
3H-CGP 12177 Whole Cell Binding Assay from Article 10.1038/sj.bjp.0706048: "The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors."
Assay data:25 Active, 7 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 25 Tested
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:1774 Active, 1 Activity ≤ 1 nM, 362 Activity ≤ 1 µM, 5242 Tested
Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis
Assay data:18 Active, 8 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Displacement of [3H]DHA from beta1 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis
Assay data:17 Active, 16 Activity ≤ 1 µM, 17 Tested
Antagonist activity at beta2 adrenergic receptor (unknown origin) expressed in HEK293 cell assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 15 mins
Assay data:17 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Antagonist activity at beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay
Assay data:30 Active, 29 Activity ≤ 1 µM, 30 Tested
Antagonist activity at beta1 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay
Assay data:23 Active, 19 Activity ≤ 1 µM, 24 Tested
Antagonist activity at human recombinant beta2 adrenoreceptor expressed in CHOK1 cells incubated for 30 mins by HTRF
Assay data:11 Active, 12 Activity ≤ 1 µM, 12 Tested
Antagonist activity at human 5HT1A expressed in BAF3 cells by fluorimetry analysis
Assay data:3 Active, 7 Activity ≤ 1 µM, 12 Tested
Displacement of [3H]-OH-DPAT from human recombinant 5-HT1A receptor measured after 60 mins by scintillation counter method
Assay data:12 Active, 7 Activity ≤ 1 µM, 12 Tested
Displacement of [3H](-)CGP 12177 from human recombinant beta2 adrenoceptor after 120 mins by scintillation counting method
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Inhibitor identification of human QSOX1 enzyme: high-throughput screening using HyperBlu(TM) assay
Assay data:979 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
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