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Cmax in CD-1 mouse plasma at 15 mg/kg, ip measured up to 24 hrs by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Binding affinity to human APJ assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human APJ receptor expressed in CHO-K1 cell membrane incubated for 60 mins under shaking condition in presence of [35S]GTPgammaS by scintillation counting method
Agonist activity at Galphaq16-fused mouse APJ receptor expressed in CHO cells assessed as stimulation of Ca2+ mobilization incubated for 1 hr by Calcium 5-dye based fluorescence based assay
Agonist activity at Galphaq16-fused human APJ receptor expressed in CHO cells assessed as stimulation of Ca2+ mobilization incubated for 1 hr by Calcium 5-dye based fluorescence based assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Agonist activity at human AGTRL1 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay
Assay data:26 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 36 Tested
Agonist activity at human APJ receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 40 mins by TR-FRET assay
Assay data:36 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 36 Tested
Cmax in CD-1 mouse brain at 15 mg/kg, ip measured up to 24 hrs by LC-MS/MS analysis
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
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