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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Antagonist activity at human TBXA2R in an in vitro cell-based assay measured by fluorescence spectroscopy
Assay data:34 Active, 15 Activity ≤ 1 µM, 906 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested
Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy
Assay data:120 Active, 64 Activity ≤ 1 µM, 812 Tested
Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy
Assay data:29 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 845 Tested
Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with cellular components measured by scintillation counting
Assay data:92 Active, 18 Activity ≤ 1 µM, 754 Tested
Inhibition of NPC1L1in human HepG2 cells assessed as increase in intracellular cholesterol content incubated for 60 mins by filipin dye based confocal microscopy analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PTL expression in human Caco-2 cells at 0.1 to 100 uM incubated for 24 hrs by Western blot analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of PTL mRNA expression in human Caco-2 cells at 100 uM incubated for 24 hrs by qRT-PCR analysis
Inhibition of NPC1L1 in human Caco-2 cells assessed as decrease in uptake of cholesterol-d6 at 50 uM by HPLC-MS analysis
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay
Assay data:1792 Active, 248 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2039 Active, 244 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:1774 Active, 1 Activity ≤ 1 nM, 362 Activity ≤ 1 µM, 5242 Tested
Chaperone activity at recombinant human GALNS expressed in Pichia pastoris assessed as increase in extracellular enzyme level by bioreactor-based assay
Assay data:1 Active, 1 Tested
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